Deregulation of CREB Signaling Pathway Induced by Chronic Hyperglycemia Downregulates NeuroD Transcription by In-Su Cho (174455)

“…Here, we show that β-cell dysfunctions occurring in chronic hyperglycemia are not caused by simple inhibition of CREB activity but rather by the persistent activation of CREB due to decreases in protein phophatase PP2A. When freshly isolated rat pancreatic islets were chronically exposed to 25 mM (high) glucose, the PP2A activity was reduced with a concomitant increase in active pCREB. …”

Data_Sheet_1_Post-implementation knowledge retention of stroke: the lasting influence of FAST Heroes.docx by Emilia Orologa (19768545)

“…</p>Methods<p>Forty-five participants engaged in the present study (35 women, 10 men; 72.8§5.3) and completed an adapted version of the FAST Heroes Stroke Preparedness Questionnaire via phone calls.…”

Data Sheet 1_Effect of sheep placenta extract on D-galactose-induced aging mouse.docx by Shan He (121220)

“…</p>Results<p>In the serum of aging mice treated with SPE, the levels of antioxidant function such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were notably higher compared to those in the blank group, whereas malondialdehyde (MDA) levels decreased. We revealed that SPE alleviated the changes in gut microbiota caused by aging in mice, with a significant decrease in the Firmicutes/Bacteroidetes (F/B) ratio in the gut. …”

Data_Sheet_1_The Role of Cognitive Control in Age-Related Changes in Well-Being.pdf by Ayano Yagi (9136775)

“…In contrast, in those who had a higher level of cognitive control ability, mental fatigue showed a steady decrease with age even after their mid-60s. …”

Investigation of chemical or enzymatic treatment of iRBCs on eKnobs. by Mathias Diehl (11530195)

“…F) Concatenation of all iRBC data from the experiments in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1009969#ppat.1009969.g005" target="_blank">Fig 5B</a> also shows a decrease in surface exposed in Δ<i>PFA</i> across all experiments. …”

Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1 by Ji Hong Kim (7430216)

“…Potential affinity peptides specific for NS1 were chosen according to the dynamic current decrease in SWV experiments. Using circular dichroism, the molar ellipticity of peptides (DGV BP1–BP5) was determined, indicating that they had a mostly similar in random coil structure, not totally identical. …”

Table 1_StSN2 enhances tuber formation in potato via upregulating of the ABA signaling pathway.pdf by Shifeng Liu (219646)

“…The research results show that deletion of the StSN2 gene led to a delay of about 14 days in the formation of potato stolons, and a decrease in yield by 20-30%. …”

Data_Sheet_1_Iodixanol density gradients as an effective phytoplasma enrichment approach to improve genome sequencing.docx by Bianca Rodrigues Jardim (9905733)

“…After density gradient enrichment, potato infected with a ‘Candidatus Phytoplasma australasia’-related strain showed a ∼14-fold increase in phytoplasma HTS reads, with a ∼1.7-fold decrease in host genomic reads compared to the DNA extracted from the same sample without density gradient centrifugation enrichment. …”

Enrichment and stability of synaptoneurosomes. by Celia Williams (265997)

“…<p>Microscopy: A) Nuclear contamination of the homogenate (2 µl smears) (DAPI fluorescence) decreases after sequential passage through mesh screens with B) the post- 10 µm screen synaptoneurosome pellet (100 µl volume) still retaining a few nuclei (Bar = 20 µm). …”

DataSheet1_Genome-wide association analysis and genomic prediction of salt tolerance trait in soybean germplasm.xlsx by Rongqing Xu (9504492)

“…And we identified 11 genes within a 5 kb window upstream and downstream of the QTLs on chromosomes 1, 3, and 16. …”

Image1_Survey of in vitro fertilization add-ons in Japan (Izanami project).tif by N. Shionoya (19815414)

“…A total of 18 add-ons were assessed, and 96.5% (423/438) of facilities used at least one add-on. …”

Collaborative approach of individual participant data of prospective studies of de-escalation in non-immunosuppressed critically ill patients with sepsis by Antonio Gutiérrez-Pizarraya (3823534)

“…<p><b>Background</b>: There is a concern to conduct de-escalation in very sick patients.…”

Image_1_Characteristics of steroid hormones in systemic lupus erythematosus revealed by GC/MS-based metabolic profiling.tif by Dehong Wu (2236318)

“…Principle component analysis demonstrated that the steroid profile was obviously distinguished between patients with SLE and controls. A lower level of total androgens was observed in patients, and nine androgens [dehydroepiandrosterone (DHEA), testosterone, Etio, androsterone, βαβ-Diol, Epi-An, Epi-DHT, 16α-OH-DHEA, and A-Diol] underwent significant decrease. …”

DataSheet1_Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment.ZIP by Ruiming Zhang (3555281)

“…<p>Background: Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). …”

DataSheet2_Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment.docx by Ruiming Zhang (3555281)

“…<p>Background: Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). …”

Longitudinal serum nAb mapping. by Tysheena P. Charles (3385586)

“…Red shading indicates a log fold reduction of 0.5log10 of greater; green shading indicates a log fold increase of 05.log10 or greater. …”

Table_1_Exercise-Induced Plasma Metabolomic Profiles in Patients With Peripheral Arterial Disease.pdf by Wendsèndaté Yves Semporé (11722121)

“…The best discriminant metabolites contributing to the model included a subset of 71 (47%) of the 150 accurately measured metabolites in the plasma, comprising 3 acylcarnitines, 3 amino acids, 5 biogenic amines, 9 sphingomyelin, 7 lysophosphatidylcholines, and 44 phosphatidylcholines. …”

Influenza-Like-Illness and Clinically Diagnosed Flu: Disease Burden, Costs and Quality of Life for Patients Seeking Ambulatory Care or No Professional Care at All by Joke Bilcke (262673)

“…The disease and economic burden were similar for ambulatory ILI patients, irrespective of whether they received a clinical diagnosis of flu. On average, they experienced 5–6 symptoms over a 6-day period; required 1.6 physician visits and 86–91% took medication. …”

Table_3_Iodixanol density gradients as an effective phytoplasma enrichment approach to improve genome sequencing.DOCX by Bianca Rodrigues Jardim (9905733)

“…After density gradient enrichment, potato infected with a ‘Candidatus Phytoplasma australasia’-related strain showed a ∼14-fold increase in phytoplasma HTS reads, with a ∼1.7-fold decrease in host genomic reads compared to the DNA extracted from the same sample without density gradient centrifugation enrichment. …”

Temporal Trends and Outcomes of Transcatheter versus Surgical Aortic Valve Replacement in Patients with Prior Myocardial Infarction by Ayman Elbadawi (4788270)

“…</p> <p><b>Results</b><b>:</b> Among 24,090 hospitalizations with prior MI undergoing isolated AVR, 58.5% underwent TAVR. Over the study period, there was an increase in the proportion of patients undergoing TAVR and a decrease in patients undergoing SAVR (P_trend<0.001). …”