Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation by Daniela De Stefano (131144)

Supplementary Material for: The 20-year trends in caries and associated determinants among adults in “post-Soviet” Lithuania: repeated cross-sectional studies by Stangvaltaite-Mouhat L. (9382166)

“…The 1997/1998 survey (first survey) recruited a stratified random sample of 570 individuals from 10 selected areas in Lithuania (response rate 52%) and the 2017/2019 survey (second survey) recruited a stratified random sample of 723 individuals from 5 biggest Lithuanian cities and one randomly selected peri-urban/rural area from each of 10 Lithuanian counties (response rate 53%). …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image_1_Addition of Fibroblast-Stromal Cell Markers to Immune Synovium Pathotypes Better Predicts Radiographic Progression at 1 Year in Active Rheumatoid Arthritis.tif by Xue-Pei Zhang (10650773)

“…The primary outcome was radiographic progression defined as a minimum increase of 0.5 units of the modified total Sharp score from baseline to 1 year.…”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image_1_Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy.tif by Irene Campi (10531166)

“…Primary endpoint was disease inactivation, measured as a decrease of the Clinical Activity Score (CAS) of at least two points. …”

The number of infiltrated ANGPTL2-positive macrophages increases in ischemic brain. by Toshihiro Amadatsu (3352955)

“…After ligation of the right common carotid artery (CCAO), we observed a 40% drop in CBF. MCA occlusion promoted a further decrease to less than 80–90% of baseline CBF. …”

Alterations in tone and FM sweeps evoked activity during repetitive stress. by Ghattas Bisharat (20706928)

“…Activity rates decreased at moderate sound intensities, while activity at high intensities remained comparable to baseline intensities (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003012#pbio.3003012.g002" target="_blank">Fig 2D</a>, 2-way ANOVA, condition F = 16.1, <i>p</i> = 6.02 × 10⁻⁰⁵, nested ANOVA (mouse nested within session) F = 16.1, <i>p</i> = 5.9 × 10⁻⁰⁵, mean ± SE). …”

Image_2_Addition of Fibroblast-Stromal Cell Markers to Immune Synovium Pathotypes Better Predicts Radiographic Progression at 1 Year in Active Rheumatoid Arthritis.tif by Xue-Pei Zhang (10650773)

“…The primary outcome was radiographic progression defined as a minimum increase of 0.5 units of the modified total Sharp score from baseline to 1 year.…”

Knockdown of Ice-Binding Proteins in <i>Brachypodium distachyon</i> Demonstrates Their Role in Freeze Protection by Melissa Bredow (3396572)

“…IBP-knockdown lines also demonstrated a significant decrease in viability following freezing to −8°C, with some lines showing only two-thirds the survival seen in control lines. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes by Yung-Ting Kuo (736349)

“…The C57BL6/J mouse was subjected to a hindlimb sciatic axotomy. A PQQ-containing ALZET® osmotic pump (equivalent to 4.5 mg/day/kg b.w.) was implanted subcutaneously into the right lower abdomen of the mouse. …”

image1_Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and I... by Babita Singh (811405)

“…An in silico study was performed using AutoDock Tools 1.5.6 (ADT).</p><p>Results: A significant recovery in behavioral parameters, dopamine level, glutathione level, lipid peroxides, and nitrite level was observed in BME-treated mice. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Fig 1 - by Kushank Bajaj (7421042)

“…We compare the crop-aggregated domestic climate impact (sensitivity of crop yields of wheat, maize, and rice to future warming) (x-axis, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0314722#pone.0314722.s009" target="_blank">S4 Fig</a>) to the consumption impact on calorie supply i.e., climate impacts on both domestic and overseas supplying regions (y-axis, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0314722#pone.0314722.s009" target="_blank">S4 Fig</a>). …”

Response kinetics and relationship to Weber’s law in the m8 controller (Fig 10). by Jonas V. Grini (15374504)

“…<p>The set-point of <i>A</i> is <i>A</i>_<i>set</i>=3.0. (a) Step-wise increase of <i>k</i>₁ from 1.0 to 5.0 at time <i>t</i>=100 at different and constant background perturbations <i>k</i>₃ (0–80). …”

Stimulation disturbs refractoriness. by Michael Schellenberger Costa (659948)

Bivalency in <i>Drosophila</i> embryos is associated with strong inducibility of Polycomb target genes by Arslan Akmammedov (6705749)

Thalamocortical loop in motor signal processing. by Rahul Agarwal (143303)