The optimal asset allocation between the S&P500 index and a risk-free asset as a function of the risk-free interest rate <i>r</i>_<i>f</i>. by Haim Levy (252011)

“…The bold line shows the optimal allocation to the stock index for a PT investor with the parameters in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0248904#pone.0248904.ref023" target="_blank">23</a>]: <i>α</i> = <i>β</i> = 0.88, <i>λ</i> = 2.25 given by <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0248904#pone.0248904.e007" target="_blank">Eq 5</a>. …”

T cell receptor excision circles as a tool for evaluating thymic function in young children by A. Levy (3995762)

“…In order to evaluate thymic function in the first years of life, we propose measuring TRECs as a valuable tool. One hundred and three blood samples from children and adolescents between 3 months and 20 years of age were analyzed. …”

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology by Sebastian Schaaf (200540)

“…However, high content experimental platforms are lacking that allow the function of hESC-derived cardiomyocytes to be studied under relatively physiological and standardized conditions. Here we describe a simple and robust protocol for the generation of fibrin-based human engineered heart tissue (hEHT) in a 24-well format using an unselected population of differentiated human embryonic stem cells containing 30–40% α-actinin-positive cardiac myocytes. …”

Genetic Ancestry-Smoking Interactions and Lung Function in African Americans: A Cohort Study by Melinda C. Aldrich (110234)

“…</p> <h3>Methodology/Principal Findings</h3><p>We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. …”

Serotonin, a downstream effector of GLP-2, enhances lacteal contractility and lymph flow by Lili Tian (12992016)

“…Utilizing a rat lymph fistula model, 5 hours after an intraduodenal (i.d.) lipid bolus, the following intraperitoneal (i.p.) administrations were applied in two different sets of experiments: Experiment 1: 1) Placebo, 2) GLP-2, 3) GLP-2 + Ketanserin (serotonin receptor antagonist). …”

Effects of Varied Housing Density on a Hybrid Mouse Strain Followed for 20 Months by Beverly Paigen (18314)

“…<div><p>To evaluate the effect of increased housing density in a hybrid mouse strain, we evaluated a panel of physiological and behavioral traits in animals that were housed in groups of 3, 5, 8, or 12, using cages that provide 78.1 in² of floor space. …”

Presentation1_Exchange flow in a highly stratified fjord in drought conditions.pdf by Elias Pinilla (20400329)

“…Using a high-resolution hydrodynamic model and the Total Exchange Flow (TEF) framework, we analyzed the impacts of river discharge, tides, and wind during a dry year (2016) and a typical year (2018). …”

A Method for Selectively Enriching Microbial DNA from Contaminating Vertebrate Host DNA by George R. Feehery (477312)

“…We report enrichment of DNA samples from human saliva, human blood, a mock malaria-infected blood sample and a black molly fish. …”

Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes by François Dion (3990335)

“…The effect of chronic kidney disease on insulin resistance was studied on two different rat strains. First, in a 5/6^th nephrectomised Sprague-Dawley rat model of chronic kidney disease, we observed a correlation between the severity of chronic kidney disease and hyperglycemia as evaluated by serum fructosamine levels (p<0.0001). …”

Simulated Meta-Analysis. by Laurynas Kalesinskas (5768810)

“…<p>A) Using simulated data in five studies, we explored the effect of changing the effect size and variance of a single study on each model’s pooled effect size, heterogeneity (τ²) and significance. …”

The interaction between tonic GABA_AR signaling and glutamatergic activity. by Michelle Day (11617621)

“…Increasing depolarization (2–3 mV to 10⁻⁵ S/cm² density) was accompanied by a dendritic spike in response to a glutamatergic input that was subthreshold in the absence of tonic GABA activation. …”

A systematic review and meta-analysis of preclinical trials testing anti-toxin therapies for <i>B</i>. <i>anthracis </i>infection: A need for more robust study designs and results by Wanying Xu (3765427)

“…Across all agents and species, agents decreased RR [0.64(0.52,0.79); I² = 5.3%, p = 0.39].…”

Analysis of the care of patients with Diabetes Mellitus and Hypertension: the experience of a small municipality in Brazil by Monica Viegas Andrade (5621213)

DataSheet1_Understanding the impact of radiotherapy fractionation on overall survival in a large head and neck squamous cell carcinoma dataset: a comprehensive approach combining m... by Igor Shuryak (337356)

“…Our previous analyses of radiotherapy-only HNSCC clinical trials data using mechanistically-motivated models of tumor repopulation and killing by radiotherapy predicted that hyperfractionation with twice-daily fractions, or hypofractionation involving increased doses/fraction and reduced treatment durations, both improve tumor control and reduce late normal tissue toxicity, compared with standard protocols using 35×2 Gy. Here we further investigated the validity of these conclusions by analyzing a large modern dataset on 3,346 HNSCC radiotherapy patients from the University Health Network in Toronto, Canada, where 42.5% of patients were also treated with chemotherapy.…”

Supplementary Material for: Eppikajutsuto Protects against Food Allergy Induced by Ovalbumin in a Murine Model by Matsui T. (4061857)

Efficacy and safety of a single radiofrequency ablation of solid benign non-functioning thyroid nodules by Roberto Cesareo (4676131)

Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes by Diane Yang (11198946)

“…Genetic analysis of an adult patient with an unusual course of Ketosis-Prone Diabetes (KPD) and lacking islet autoantibodies demonstrated a nucleotide variant in the<i> </i>5’-UTR of <i>PDX1</i>, a beta-cell development gene. …”

Intrinsic and extrinsic fluorescence spectroscopy of the protease 1147. by Hossein Tarrahimofrad (9016994)

Inequalities in Alcohol-Related Mortality in 17 European Countries: A Retrospective Analysis of Mortality Registers by Johan P. Mackenbach (147412)

“…<div><p>Background</p><p>Socioeconomic inequalities in alcohol-related mortality have been documented in several European countries, but it is unknown whether the magnitude of these inequalities differs between countries and whether these inequalities increase or decrease over time.</p><p>Methods and Findings</p><p>We collected and harmonized data on mortality from four alcohol-related causes (alcoholic psychosis, dependence, and abuse; alcoholic cardiomyopathy; alcoholic liver cirrhosis; and accidental poisoning by alcohol) by age, sex, education level, and occupational class in 20 European populations from 17 different countries, both for a recent period and for previous points in time, using data from mortality registers. …”

Livers taken at different time points after a single administration of CClwere homogenized and used with a human-TNF-α and human-TNF-β EIA-kit or rat-IFN-γ ELISA-kit by Katrin Neubauer (48437)