EGFR/ERK signaling activity decreases throughout LEC elimination with endocytic activity dependency. by Kevin Yuswan (19845885)

Exposure to low CO₂ levels decreases ER cholesterol levels. by Nityanand Bolshette (17396845)

“…<b>(C)</b> Total cholesterol quantification (with fluorometric assay kit) in NIH3T3 cells depleted with sterols for 2 h or exposed to different CO₂ levels for 4 h (mean ± SE, <i>n</i> = 3 biological replicates per condition, **<i>P</i> < 0.01, nonsignificant (ns), two-sided Student’s <i>t</i> test). <b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …”

Treatment with TDF decreased cell viability and induced morphological changes in hepatic stellate cells. by Sung Won Lee (222509)

Overexpression of mC4 decreased membrane capacitance without altering overall excitability. by Ashley L. Comer (8299128)

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. by Jian Zhang (1682)

Thermal denaturation of ZIKV NS2B/NS3^pro and CHIKV nsP2^pro using fluorescence spectroscopy. by Raphael J. Eberle (9286932)

Downregulation of TRIM37 expression exacerbates pathological damage in the MS model. by Lai Jiang (2401513)

“…Scale bar = 50 μm. (h) qRT-PCR (n = 6) and <b>(i, j)</b> Western blot (n = 3) both showed a significant decrease in the <i>TRIM37</i> mRNA and protein levels in the LPC-induced MS model compared to the control group. * <i><i>P</i></i> < 0.05, ** <i><i>P</i></i> < 0.01, *** <i><i>P</i></i> < 0.001, **** <i><i>P</i></i> < 0.0001, ns = not significant.…”

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…Anthropogenic activities, particularly land use change and management practices, alter the global nitrogen (N) cycle. As a central part of the global N cycle, soil N supply from net N mineralization (NNM) and net nitrification (NN) contributes to over 50% of crop N uptake. …”

Detailed meta–analyses in untreated hypothyroid patients compared with controls for each HRV parameters: RR intervals, SDNN, RMSSD, pNN50, TP, LF, HF, LF/HF. by Valentin Brusseau (12769704)

Pulse Ultrasound-Based Response Enhancement of a MOX Gas Sensor by Yumin Yang (5737235)

“…For 2 ppm methanol, the RE by the pulse ultrasound is 50%, relative to the continuous ultrasound, when the pulse width, duty ratio, and working frequency are 0.4 ms, 50%, and 110.1 kHz, respectively. …”

Pulse Ultrasound-Based Response Enhancement of a MOX Gas Sensor by Yumin Yang (5737235)

“…For 2 ppm methanol, the RE by the pulse ultrasound is 50%, relative to the continuous ultrasound, when the pulse width, duty ratio, and working frequency are 0.4 ms, 50%, and 110.1 kHz, respectively. …”

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Hepatitis C virus (HCV) is a human pathogen with high morbidity. The HCV NS3/4A protease is essential for viral replication and is one of the top three drug targets. …”

Variable importance plot (mean decrease accuracy and mean decrease Gini). by Fernando Martinez-Taboada (8655132)

Untargeted metabolomic analysis of delayed death-parasites indicates isoprenoid defect and decreased haemoglobin turnover. by Kit Kennedy (4915510)

Decreasing fluconazole susceptibility of clinical South African <i>Cryptococcus neoformans</i> isolates over a decade by Serisha D. Naicker (8648370)

miR-200c decreases KLOTHO expression in HK-2 cells by translational repression. by Kenichi Morii (6843554)

AIM-100 reduces dsRNA silencing in body wall muscle and decreases DA neurodegeneration. by Anthony L. Gaeta (13272609)

Prevalence and anatomic level of stenosis ≥ 50% in either limb. by O. Stivalet (6890189)

Olaparib reverses the oxLDL-mediated decrease in co-immunoprecipitation of IκBα with RelA or p50. by Khamis Mustafa (17941332)

“…Relative band densities from three independent experiments were analyzed. (A) OxLDL decreased co-immunoprecipitation of IκBα with both RelA and p50, and olaparib reversed the effect of oxLDL on the dissociation of IκBα with RelA and p50. …”

GC-MS chromatogram of garlic essential oil. by Huda H. Elbehery (22492996)

“…GO-GA NPs enhanced the persistence activity, exhibiting a continued toxic effect for >30 days, with a PT₅₀ of 22.29 days compared to 12.79 days for GO. …”