LC treatment selectively induces expression of p21^cip1 gene, mRNA and protein in cancer cells. by Hongbiao Huang (292949)

“…HepG2 cells were treated with LC (2.5, 5.0, 10 mM) for 24 h; cells were collected for gene expression profile analysis. …”

Data Sheet 1_Treatment with pemafibrate ameliorates fatty liver index and atherogenic lipid profiles in Japanese patients with type 2 diabetes mellitus.pdf by Toru Suzuki (512729)

“…There was no significant change in hemoglobin A1c level over time. FLI (mean ± standard deviation: 68.1 ± 21.9 vs. 39.6 ± 25.0, P < 0.001), but not FIB-4 index as a marker of hepatic fibrosis (median [interquartile range]: 1.04 [0.78-1.39] vs. 1.01 [0.68-1.36], P = 0.909), was significantly decreased by treatment with pemafibrate for 12M, and the proportion of patients with metabolic dysfunction-associated SLD (MASLD) was significantly decreased from 92.3% (baseline) to 61.5% (12M).…”

The effects of SERCA inhibition. by Ilanit Itzhaki (225708)

“…(<b>B</b>) Dose-response effects of thapsigargin (1, 5, 10 and 20 µM) on [Ca²⁺]_i transients amplitude (displayed as percentage decrease versus baseline values). …”

Fsn0503 inhibits angiogenesis <i>in vivo</i>; CD34 Immunohistochemical analysis of Fsn0503 treated tumors. by Claire Ward (362061)

“…<p>(<b>A</b>) Pattern of small vessel (white arrows) and large vessel (black arrows) distribution in isotype control and Fsn0503 treated tumors (10 mg/kg 5 times a week for 4 weeks) (20×). (<b>B</b>) Analysis of total vessel number as characterized by CD34 staining shows that Fsn0503 caused an increase in small vessel number and a significant decrease in the number of large vessels (p<0.001). …”

Pharmacology of the Adenosine A₃ Receptor in the Vasculature and Essential Hypertension - Fig 4 by Ming-Fen Ho (2265538)

“…<p>Mean decrease in (A) left ventricular developed pressure (LVDP) and (B) the left ventricle contractility (dP/dt) maximum at the concentration of 10^-5M of APNEA or CL-IB-MECA for control normotensive rats (NT) and spontaneously hypertensive rats (SHR). …”

Sucrose consumption test. by Rafael Delgado y Palacios (498616)

“…<p>The rats were presented with a sucrose solution (1.5%) for one hour after 14 hours of food and water deprivation in order to evaluate their hedonic state during the CMS procedure (8 weeks). …”

Figure S1 - Increased Anion Channel Activity Is an Unavoidable Event in Ozone-Induced Programmed Cell Death by Takashi Kadono (239850)

“…<p><b>Effect of O₃ on mitochondrial membrane potential (Δψm) of </b><b> <i>A. thaliana</i> </b><b> cells.</b> Mean values of JC-1 fluorescence ratio (high ψm versus low ψm) measured 15 minutes after exposing the cells to ozonized air for 10 min and effect of 5 mM dabco and 200 µM glibenclamide (gli) on the decrease of JC1 fluorescence ratio induced by O3. …”

Non-searching strategies in the Morris water maze test. by Glòria Arqué (51650)

“…<p>Floating behavior (A and B) was operationally defined as any period equal to or longer than 5 s, during which the average mouse swimming speed stayed below 3 cm.s⁻¹. …”

Cell viability curves for Diclofenac, Chlorpromazine, Acetaminophen, and Verapamil. by Milena Mennecozzi (718240)

“…<p>5000 human primary hepatocytes pooled from either 12 male donors (M), or 12 pre-menopausal female donors (3F), or 12 post-menopausal female donors (4F) were seeded in 96 well plates and exposed to 8 serial concentrations (using a dilution factor of 1:2) of Diclofenac (from 13.6 to 1750 uM), Chlorpromazine (from 1.9 to 250 uM), Acetaminophen (from 0.3 to 35 uM), or Verapamil (from 7.8 to 1000 uM). Decrease in cell number after 30 min, 2h, or 5h exposure to drugs was assessed by lysing the cells with CellTiter-Glo Reagent and measuring the ATP levels released. …”

The effects of pretreatment with fingolimod-phosphate on BMECs in the presence of MS sera. by Hideaki Nishihara (545149)

“…Pretreatment with fingolimod-phosphate resulted in an increase in the claudin-5 protein levels (B) and TEER values (G) and a decrease in the VCAM-1 protein levels (F) in the BMECs, which were upregulated after exposure to the sera from all MS patients, including the RRMS-R, RRMS-S and SPMS patients, compared to that observed in the cells not pretreated with fingolimod-phosphate.…”

AR-dependent tumor suppression was associated with increased cellular senescence. by Yelena Mirochnik (179447)

“…Male athymic mice (nu/nu, 5 mice/group) were injected s.c. with vector control (PC3-V) or PC3-AR cells and received Dox with drinking water, where indicated, to induce AR expression. …”

Increasing dead cell burden in wounds resulted in increased pro-inflammatory cytokine levels. by Savita Khanna (252283)

“…Data (mean ±SD, n = 5) are presented as <i>pg</i> cytokine per <i>mg</i> wound tissue. *, <i>p</i><0.05 compared to IgG treated control side.…”

Between-group comparison: personal familiarity irrespective of stimulus type. by Luisa Jurjanz (351105)

“…<p>The figure shows brain areas with relative decrease in neural activity among aMCI patients when compared to control subjects, associated with familiar>unfamiliar stimulus content irrespective of stimulus type. …”

Atrial and ventricular connexins and sodium channel genes expression levels in wt and Ts65Dn mice. by Matthieu Raveau (160575)

“…No amplification was obtained for <i>Cx30.2</i> in ventricle extracts confirming its atria specific expression pattern. Mean±sem with Student t-test <i>P</i>-values, N = 7 and 5 for Ts65Dn and wt respectively.…”

Different kinetics of cells positive to MPO in hamster and mouse ALAs model. by Andrea Cruz-Baquero (4347916)

“…In mice the MPO was positive at 6 and 12 h and decrease importantly at 24 h. Data represent the mean ± SD of three independent experiments (n = 5). …”

AprA, CfaD, and QkgA are required for inhibition of proliferation by BzpN. by Jonathan E. Phillips (214646)

“…<p>Proliferation curves were done as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021765#pone-0021765-g001" target="_blank">Figure 1</a>. Values are mean ± SEM, n≥3. Expression of BzpN-GFP in wild-type cells resulted in a significant decrease in cell density on days 5 through 8 with p<0.05, whereas expression of BzpN-GFP in <i>aprA⁻, cfaD⁻, or qkgA⁻</i> cells did not cause a significant reduction in cell density at any measured timepoint (t-test). …”

Effects of (a) AG-490 and (b) WHI-P154 on IFN-γ-induced nitric oxide (NO) generation in J774 macrophages by Outi Sareila (66176)

“…The values are mean ± SEM ( = 6), * < .05, and ** < .01 when compared to cells treated with IFN-γ alone.…”

Consumer Impacts (CI) for each reach (Within) and the differences (ΔCI) between reaches (Between). by Michael C. Marshall (130087)

“…Positive values indicate increase in response variable with consumers, whereas negative values indicate a decrease. Each bar is the mean (±1 SE) of 5 replicates. …”

Fluoro-Ruby-labeled motoneurons at 13 weeks after immediate nerve repair (A), 1 months delayed repair (B), 3 months delayed repair (C) and 6 months delayed repair (D). by Samuel Jonsson (284555)

“…(E) Histogram showing the quantification of mean±SEM number of regenerating spinal motoneurons after 0–6 months (mo) delayed repair. n = 5, *p<0.05 (3 mo vs, 6 mo), ***p<0.001 (0 mo and 1 mo vs 3 mo and 6 mo).…”

IL-1β treatment does not induce cell death. by Himakarnika Alluri (2735689)

“…<p>IL-1β (10 ng/mL; 2 hours) treatment had no effect on cell viability (n = 5). Hydrogen peroxide (used as a positive control) treatment decreases cell viability significantly (<i>p<</i>0.05). …”