Docking of LDCVs Is Modulated by Lower Intracellular [Ca²⁺] than Priming by Mathias Pasche (74950)

“…The parameters that reflect docking, i.e. axial mobility and the fraction of LDCVs residing at the plasma membrane for less than 5 seconds, were strongly decreased at a free [Ca²⁺]_i of 500 nM. …”

Reconciling a Kinetic Model for Dimerization of the EGFR Using Single-Molecule Tracking in Living Cells by Kiwook Kim (756439)

High-Throughput Identification of Chemical Inhibitors of <em>E. coli</em> Group 2 Capsule Biogenesis as Anti-Virulence Agents by Carlos C. Goller (245570)

“…Components of assembly and export are highly conserved among the major K antigen capsular types associated with UTI-causing <em>E. coli</em> and are distinct from the capsule biogenesis machinery of many commensal <em>E. coli</em>, making these attractive therapeutic targets. We conducted a screen for anti-capsular small molecules and identified an agent designated “C7” that blocks the production of K1 and K5 capsules, unrelated polysaccharide types among the Group 2–3 capsules. …”

Data_Sheet_2_Rewiring of Gene Expression in Pseudomonas aeruginosa During Diauxic Growth Reveals an Indirect Regulation of the MexGHI-OpmD Efflux Pump by Hfq.pdf by Marlena Rozner (12911555)

“…As Hfq function is impeded by the RNA CrcZ upon relief of CCR, and Hfq is known to impact antibiotic susceptibility in P. aeruginosa, emphasis was laid on links between CCR and antibiotic susceptibility. To this end, we show that the mexGHI-opmD operon encoding an efflux pump for the antibiotic norfloxacin and the virulence factor 5-Methyl-phenazine is upregulated after alleviation of CCR, resulting in a decreased susceptibility to the antibiotic norfloxacin. …”

DataSheet1_Deficiencies in the Recognition and Reporting of Chronic Kidney Disease in Patients With Type 2 Diabetes Mellitus; A Hungarian Nationwide Analysis.PDF by Erzsébet Ladányi (16897194)

“…The annual incidence of T2DM and incidence rates of CKD in T2DM decreased in 2017–2020 (p < 0.001). The annual prevalence of T2DM increased (p < 0.01), the prevalence rates of CKD in T2DM were low and decreased from 9.8% to 6.5% in 2016–2020 (p < 0.001).…”

Table_1_Synergistic Modulations of Large-Scale Synoptic Patterns and Local-Scale Urbanization Effects on Summer Rainfall in South China.DOCX by Minxuan Zhang (11829497)

“…<p>Using the ERA5 (the fifth major global reanalysis produced by the European Centre for Medium-Range Weather Forecasts) data and the T-PCA (Principal Component Analysis in T-mode) objective classification method to classify the 850-hPa geopotential height, we summarize four conceptual models of large-scale synoptic weather types over East Asia. …”

FcRn is responsible for pH/antibody-mediated enhanced transcytosis of HIV-1. by Sandeep Gupta (79684)

“…Fm-6 is an anti-SARS coronavirus IgG1 used as a negative control. All mAbs were tested at 50 µg/ml. …”

Table_1_Markers of T Cell Exhaustion and Senescence and Their Relationship to Plasma TGF-β Levels in Treated HIV+ Immune Non-responders.docx by Carey L. Shive (10431701)

“…Selected participants were <50 years old to control for the confounder of older age.…”

Table_1_Effect of Psychological Intervention on Pelvic Floor Function and Psychological Outcomes After Hysterectomy.docx by Meilian Xie (12451293)

“…</p>Methods<p>Ninety-nine patients underwent hysterectomy were randomly divided into intervention group (n = 50) and control group (n = 49). Patients in the control group received routine postoperative nursing care, while extra psychological intervention was provided to patients in the intervention group, including psychological support, regular lectures and family support. …”

Presentation_1_Markers of T Cell Exhaustion and Senescence and Their Relationship to Plasma TGF-β Levels in Treated HIV+ Immune Non-responders.PPTX by Carey L. Shive (10431701)

“…Selected participants were <50 years old to control for the confounder of older age.…”

BMI (crude values and <i>z</i>-scores) age trend with 95% confidence intervals by haplotypes (CCT/x, red, vs carriers of the most prevalent haplotype, TTC, blue) in boys and girls. by Francesco Gianfagna (440763)

Table_1_Application of Strategic Transport Model and Google Maps to Develop Better Clot Retrieval Stroke Service.DOCX by Atousa Tajaddini (6893573)

“…Futures modeling using VITM found that this proportion decreases to 82% after 5 years and 80% after 10 years. …”

Data Sheet 2_Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.pdf by Samira Rastgoo (15252703)

“…</p>Results<p>After the intervention, supplementation with D5N and D5 significantly downregulated p16, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) expression and decreased SA-β-gal activity compared to the D1 group. …”

Data Sheet 1_Beta tACS of varying intensities differentially affect resting-state and movement-related sensorimotor power.docx by Kym Wansbrough (19711762)

“…For event-related activity, we observed intensity-dependent changes in bilateral broadband power (4–90 Hz): during movement preparation, 1.0 mA stimulation increased power; during movement termination, 0.5 mA stimulation decreased power while 1.0 mA and 1.5 mA stimulation induced comparable increases in power. …”

Image_3_Trends in radiotherapy administration in the management of hepatocellular carcinoma: Analysis of a Korean tertiary hospital registry of hepatocellular carcinoma patients di... by Bong Kyung Bae (8736945)

“…With the technical developments, the overall survival (OS) of patients who received radiotherapy as initial management increased significantly (5-year OS: from 5.4% to 30.1%), and the OS difference between patients who did and did not receive radiotherapy as initial management significantly decreased (ratio of restricted mean survival time: from 0.383 to 0.544).…”

Image_4_CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.JPEG by Tanwir Hashem (8825765)

“…Interestingly, Il13 but not Il4 or Il5 gene expression in the lungs was dramatically decreased in HDME-exposed Cd2^−/− mice. …”

Image_1_CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.JPEG by Tanwir Hashem (8825765)

“…Interestingly, Il13 but not Il4 or Il5 gene expression in the lungs was dramatically decreased in HDME-exposed Cd2^−/− mice. …”

Micelle and Inverse Micelle Structure Driven Viscoelasticity and Phase Separation in 2‑Isobutoxyethanol–Water Mixtures: Insights from All-Atom Simulations by Mayank Dixit (7879364)

“…We observed the presence of the inverse micelle structure in <i>x</i>_IBE = 0.5 and micelle structures in <i>x</i>_IBE = 0.1. …”

Tamoxifen-Induced Epigenetic Silencing of Oestrogen-Regulated Genes in Anti-Hormone Resistant Breast Cancer by Andrew Stone (107521)

“…One such gene candidate, growth differentiation factor 15 (GDF15), was carried forward for functional analysis. The addition of 5-Aza/E2 was sufficient to de-methylate and activate GDF15 expression in the tamoxifen resistant cell-lines, whilst in parallel, treatment with recombinant GDF15 protein decreased cell survival. …”

Limited detection of small (≤ 10 mm) colorectal liver metastasis at preoperative CT in patients undergoing liver resection by Yousun Ko (4688230)

“…</p><p>Results</p><p>Fourteen nodule sizes were missing in the pathology report. Nodules of 1–5 mm and 6–10 mm accounted for 8.1% (n = 36) and 23.5% (n = 105) of the remaining 447 nodules, and the number of nodules gradually decreased as nodule size increased beyond 10 mm. …”