Dexmedetomidine (Dex) reversed isoflurane-induced inhibition of Akt activity and decrease of Bcl-xL/Bad ratio in the hippocampus of P7 rats (n = 7 in each group). by Yujuan Li (554062)

Boxplot showing differences in vertebral cross-sectional growth between girls with increased (<i>n</i> = 14) and decreased vertebral body wedging (<i>n</i> = 13); <i>p</i> = 0.001. by Ervin Poorghasamians (3801475)

TR4 and TR9 decrease hepatoma cell viability at a lower TC50 than Sorafenib, SAHA or 5-Fluorouracil. by Nicole Lange (335740)

Tacrolimus Decreases Albuminuria in Patients with IgA Nephropathy and Normal Blood Pressure: A Double-Blind Randomized Controlled Trial of Efficacy of Tacrolimus on IgA Nephropathy by Yong-Chul Kim (1637572)

“…The pre-defined secondary outcomes were better in the Tac group compared to the control group. The frequency of decrease in pcUACR and percentage change of UPCR (pcUPCR) ≥50% at 16 weeks were 65.0% (13/20) and 55.0% (11/20)in the Tac group, and 25.0% (5/20) and 15.0% (3/20), in the control group, respectively (p = 0.025 for pcUACR and p = 0.019 for pcUPCR). …”

A Yoga Strengthening Program Designed to Minimize the Knee Adduction Moment for Women with Knee Osteoarthritis: A Proof-Of-Principle Cohort Study by Elora C. Brenneman (795723)

“…A secondary objective was to determine whether the program could improve mobility and fitness, and decrease peak KAM during gait. …”

Taurolidine lock solution for catheter-related bloodstream infections in pediatric patients: A meta-analysis by Yan Sun (22436)

“…The number of catheters removed due to infection or suspected infection was not significantly different between the two groups (RR: 0.68; 95% CI:0.22, 2.10; I² = 56%; P = 0.50) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0231110#pone.0231110.g005" target="_blank">Fig 5</a>). …”

Intracellular images (×20000) of <i>S</i>. <i>cerevisiae</i> strain BH8 before (a) and after (b, c) culturing in MSM with 1.50 mM Cu²⁺ for 48 h; CW: cell wall; N: cell n... by Xiang-yu Sun (748032)

Upregulation of autophagy decreases the age-related accumulation of hyperphosphorylated tau and ameliorates tau-induced locomotor defects in human Tau (0N3R) expressing transgenic... by Shreyasi Chatterjee (3531506)

Localization of key HH signaling proteins is impaired in <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia. by Emily Bowie (543704)

Effect of melatonin (50 μM) on the TGF-β1 (10 ng/mL, 72 h)-mediated TGF-β1/Smad pathway and EMT in HBdSMCs. by Yang Zhang (30734)

Here we speculate on the possible interactions between cell autonomous circadian and somite oscillator components during somite formation and differentiation. by Kristen L. Curran (95520)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell by Jude T. Deeney (335344)

“…Here, we demonstrate multiple improvements in pancreatic β-cells upon BET inhibition with JQ1 or BET-specific siRNAs. JQ1 (50–400 nM) increases insulin secretion from INS-1 cells in a concentration dependent manner. …”

rhIL-4 and rhIL-13 decrease LEC proliferation and downregulate expression of Prox-1. by Ira L. Savetsky (749034)

Influence of ghrelin treatment (0.5 μg/g BW, twice a day, intraperitoneal (ip.)) on bacterial load after cecal ligation and puncture (CLP)-induced sepsis. by Daniel Siegl (717509)

Influence of ghrelin treatment (0.5 μg/g BW, twice a day, intraperitoneal (ip.)) on inflammatory mediators after cecal ligation and puncture (CLP)-induced sepsis. by Daniel Siegl (717509)

Non-Pneumatic Anti-Shock Garment (NASG), a First-Aid Device to Decrease Maternal Mortality from Obstetric Hemorrhage: A Cluster Randomized Trial by Suellen Miller (294598)

“…We hypothesized the NASG group would have a 50% reduction in adverse outcomes.</p><p>Methods and Findings</p><p>We randomly assigned 38 PHCs in Zambia and Zimbabwe to standard obstetric hemorrhage/shock protocols or the same protocols plus NASG prior to transport. …”

Structurally distinct inhibitors of Chk1 decrease Chk1 nuclear fluorescence following heating in a low well volume. by Andrew J. Massey (239469)

Sensitivity analysis. by Jiuming Li (11711375)

“…According to the follow-up, 271 (56.7%) were in the exclusive breastfeeding group and the rest in the non-exclusive breastfeeding group (n = 207, 43.3%). A significant decrease in exclusive breastfeeding rate was observed in the prolonged TTP group compared to the short TTP group (OR=0.46, 95% CI: 0.27–0.74). …”

Characteristics of participants. by Jiuming Li (11711375)

“…According to the follow-up, 271 (56.7%) were in the exclusive breastfeeding group and the rest in the non-exclusive breastfeeding group (n = 207, 43.3%). A significant decrease in exclusive breastfeeding rate was observed in the prolonged TTP group compared to the short TTP group (OR=0.46, 95% CI: 0.27–0.74). …”

Participant Flowchart. by Jiuming Li (11711375)

“…According to the follow-up, 271 (56.7%) were in the exclusive breastfeeding group and the rest in the non-exclusive breastfeeding group (n = 207, 43.3%). A significant decrease in exclusive breastfeeding rate was observed in the prolonged TTP group compared to the short TTP group (OR=0.46, 95% CI: 0.27–0.74). …”