Showing 981 - 1,000 results of 27,531 for search '(( 50 ((n decrease) OR (a decrease)) ) OR ( 50 ((mean decrease) OR (we decrease)) ))', query time: 1.05s Refine Results
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    Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α<sub>1A</sub>-Adrenoceptor Antagonists by Fei Zhao (183673)

    Published 2016
    “…In this study, two highly selective and potent α<sub>1A</sub>-AR antagonists, compounds (<i>R</i>)-<b>14r</b> (IC<sub>50</sub> = 2.7 nM, α<sub>1B</sub>/α<sub>1A</sub> = 640.1, α<sub>1D</sub>/α<sub>1A</sub> = 408.2) and (<i>R</i>)-<b>23l</b> (IC<sub>50</sub> = 1.9 nM, α<sub>1B</sub>/α<sub>1A</sub> = 1506, α<sub>1D</sub>/α<sub>1A</sub> = 249.6), which exhibited similar activities and better selectivities in cell-based calcium assays as compared with the marketed drug silodosin (IC<sub>50</sub> = 1.9 nM, α<sub>1B</sub>/α<sub>1A</sub> = 285.9, α<sub>1D</sub>/α<sub>1A</sub> = 14.4), were identified. …”
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    Postnatal decrease in PV+ cortical interneurons in Fgfr1 mutant mice. by Karen Müller Smith (613941)

    Published 2014
    “…Scale bar is 50 µm in <b>A</b>,<b>B</b>. Stereological analysis show significant decreases in in both GFP and PV immunopositive cells in Fgfr1 mutant mice as compared to littermate controls (<b>C</b>). …”
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    TUT1 suppression yields broad decreases in miRNA expression. by Emily C. Knouf (434880)

    Published 2013
    “…(<b>A</b>) We compared the abundance of miRNAs detectable with at least 50 counts on the NanoString platform in the enzyme suppressed vs. negative control siRNA-transfected cells. …”
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