Showing 521 - 540 results of 34,344 for search '(( 50 ((n decrease) OR (mean decrease)) ) OR ( 5 ((nn decrease) OR (we decrease)) ))', query time: 0.73s Refine Results
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    Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

    Published 2022
    “…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. …”
  7. 527

    Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

    Published 2022
    “…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. …”
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    PRISMA flow diagram. by Apoorva Anand (17921197)

    Published 2024
    “…COVIDST decreased closures in school, workplace, and social events (n = 4). …”
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    Meta-analyses of COVIDST diagnostic accuracy. by Apoorva Anand (17921197)

    Published 2024
    “…COVIDST decreased closures in school, workplace, and social events (n = 4). …”
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    Removal of specific N-glycans can alter neutralization potency and completeness. by Sabrina Lusvarghi (2329267)

    Published 2023
    “…Colors as follow: red, decrease in potency >4-fold; white, no change in IC<sub>50</sub> (ratios between 0.25- and 4-fold) and blue increase in potency (ratios <0.25-fold). …”
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