Image_2_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.TIF by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Image_1_Investigating miR-9 as a mediator in laryngeal cancer health disparities.jpeg by Christina Gobin (15181795)

Table_1_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.docx by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Image_3_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.TIF by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Data_Sheet_2_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.docx by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Image_1_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.TIF by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

Data_Sheet_1_TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.docx by Andrew J. McNair (9093310)

“…SMAD2 antagonism by siRNA and the SMAD7 agonist asiaticoside decreased detection of pSMAD by at least 50%, significantly decreased expression of the aVIC gene markers ACTA2, TAGLN, and MYH10, and pαSMA, pAKT2, and pERK1, but had no effect on pS6K, pERK2, or pVIM expression in aVICs. …”

DataSheet_1_Investigating miR-9 as a mediator in laryngeal cancer health disparities.docx by Christina Gobin (15181795)

DataSheet_1_Does Routine Anti-Osteoporosis Medication Lower the Risk of Fractures in Male Subjects? An Updated Systematic Review With Meta-Analysis of Clinical Trials.doc by Ling-Feng Zeng (7172462)

“…</p><p>Conclusions: This systematic review confirms that bisphosphonates were connected with a decreased risk of vertebral fractures, nonvertebral fractures, and clinical fractures for male subjects with osteoporosis. …”

Video_1_Reverse-sequence endoscopic nipple-sparing mastectomy with immediate implant-based breast reconstruction: an improvement of conventional minimal access breast surgery.mov by Kawun Chung (18111136)

“…Patients in the R-E-NSM group had significantly shorter operation time (204.6 ± 59.2 vs. 318.9 ± 75.5 minutes, p<0.001) and anesthesia time (279.4 ± 83.9 vs. 408.9 ± 87.4 minutes, p<0.001) and decreased medical costs [5063.4 (4439.6-6532.3) vs. 6404.2 (5152.5-7981.5), USD, p=0.001] and increase SCAR-Q scores (77.2 ± 17.1 vs. 68.8 ± 8.7, P=0.002) compared to the C-E-NSM group. …”

Supplementary file 1_Ultrafine garlic powder alleviates non-alcoholic steatohepatitis by inhibiting hepatocyte ferroptosis and modulating ERK-dependent oxidative stress.docx by Junhui Yu (8899847)

“…</p>Results<p>UGP exhibited a particle size (d(0.5) of approximately 4 μm) that is 30 times smaller than TGP, showing significantly smaller particle size and lower contact angle (UGP=59.775°vs TGP=83.545°). …”

Image1_Training at moderate altitude improves submaximal but not maximal performance-related parameters in elite rowers.pdf by Hugo Cerda-Kohler (5755775)

“…LHTL training improves performance-related variables at sea level (V̇E_max: 3.3% (95% CI, 1.2–5.5); hemoglobin concentration ([Hb]): 4.3% (95% CI, 1.7–6.9); hematocrit (%): 4.5% (95% CI, 0.9–8.2); RBC (red blood cells) count: 5.3% (95% CI, 2.3–8.2); power at VT2: 6.9% (95% CI, 1.7–12.1), V̇E_VT2: 6.4% (95% CI, 0.4–12.4); power at VT1: 7.3% (95% CI, 1.3–13.3), V̇E_VT1: 8.7% (95% CI, 1.6–15.8)) and economy/efficiency-related variables (ECR_VT2: 5.3% (95% CI, −0.6 to −10.0); GE(%): 5.8% (95% CI, 0.8–10.7)). The LHTH training decreased breathing economy at MAP (−2.8% (95% CI, 0.1–5.6)), pVT2 (−9.3% (95% CI, −5.9 to −12.7)), and pVT1 (−9.3% (95% CI, −4.1 to −14.4)). …”

DataSheet_1_177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry.docx by Ayman Abouzayed (17051256)

“…The binding of [¹⁷⁷Lu]Lu-BQ7876 to living cells was characterized by rapid association, while the dissociation included a rapid and a slow phase with affinities K_D1 = 3.8 nM and K_D2 = 25 nM. …”

Fine Mapping and Candidate Gene Search of Quantitative Trait Loci for Growth and Obesity Using Mouse Intersubspecific Subcongenic Intercrosses and Exome Sequencing by Akira Ishikawa (267667)

“…We fine-mapped <i>Pbwg1.3</i> for body length to an 8.0-Mb interval (57.3–65.3) and <i>Pbwg1.5</i> for abdominal white fat weight to a 2.1-Mb interval (59.4–61.5). The wild-derived allele at <i>Pbwg1.12</i> and <i>Pbwg1.3</i> uniquely increased body weight and length despite the fact that the wild mouse has a smaller body size than that of B6, whereas it decreased fat weight at <i>Pbwg1.5</i>. …”

Interferon-free therapy with direct acting antivirals for HCV/HIV-1 co-infected Japanese patients with inherited bleeding disorders by Haruka Uemura (4521400)

“…</p><p>Results</p><p>Eighteen (67%) patients had had received interferon-based therapy, and 11 (41%) had compensated cirrhosis. HCV genotypes were GT1a 4 (15%), GT1b 16 (59%), GT1 undetermined 2 (7%), GT2a 1 (4%), GT3a 3 (11%) and GT4a 1 (4%). …”

RNA-seq transcriptomics analysis in human tissue culture cells reveals changes in the expression levels of over 100 nucleolar mRNAs after PAX9 knockdown. by Katherine I. Farley-Barnes (9258036)

“…Of these, 812 mRNAs had a decreased fold change (≤ -2) and 184 of those mRNAs code for proteins designated as nucleolar in at least one of three databases [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008967#pgen.1008967.ref050" target="_blank">50</a>–<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008967#pgen.1008967.ref052" target="_blank">52</a>]. …”

<i>Csp_P</i> exposure causes high mortality in adults and larvae. by Jose Luis Ramirez (179343)

“…In septic <i>Ae. aegypti</i>, survival was significantly decreased after feeding on a 10¹⁰ CFU/ml sugar meal (D, p<0.0001) but not after feeding on a 10⁶ CFU/ml sugar meal (D, p = 0.08). …”

Pharmacological blockade of K_ATP channels negates the hippocampal synaptic and neuronal protection afforded by ketones. by Do Young Kim (131974)

“…Each vertical bar indicates the mean ± SEM (n = 30). (D) Representative photomicrographs of HT22 cells under control conditions, with H₂O₂, or when H₂O₂ was co-treated with ACA at two time-points (0 and 24 hrs). …”

Genome-wide miRNA response to anacardic acid in breast cancer cells by David J. Schultz (4423906)

“…Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell proliferation with IC₅₀s of 13.5 and 35 μM, respectively. To identify potential mediators of AnAc action in breast cancer, we profiled the genome-wide microRNA transcriptome (microRNAome) in these two cell lines altered by the AnAc 24:1n5 congener. …”

Influence of T180A-SHIP2 on LEC functional responses. by Germaine D. Agollah (623510)

“…Scale bar  = 100 µm (<b>B</b>) and 50 µm (<b>C</b> and <b>D</b>) MW =  molecular weight marker.…”