Label-free real-time multi-parametric monitoring enables high content analysis. by Heinz-Georg Jahnke (122745)

“…The effect on the APD was determined for one hour after doxorubicin application and revealed a concentration dependent response with an EC₅₀ value of 17 µM (n  = 3 hCMC), (B) The impedance analysis revealed a concentration- and time-dependent decrease where IC₅₀ values could be determined for each time point (n  = 5 hCMC). …”

Image_1_Effects of Combined Oxytocin and Beta-3 Receptor Agonist (CL 316243) Treatment on Body Weight and Adiposity in Male Diet-Induced Obese Rats.jpg by Melise M. Edwards (11405780)

“…OT and CL 316243 alone reduced body weight by 7.8 ± 1.3% (P < 0.05) and 9.1 ± 2.1% (P < 0.05), respectively, but the combined treatment produced more pronounced weight loss (15.5 ± 1.2%; P < 0.05) than either treatment alone. These effects were associated with decreased adiposity, adipocyte size, energy intake and increased uncoupling protein 1 (UCP-1) content in epididymal white adipose tissue (EWAT) (P < 0.05). …”

Image_2_Effects of Combined Oxytocin and Beta-3 Receptor Agonist (CL 316243) Treatment on Body Weight and Adiposity in Male Diet-Induced Obese Rats.jpg by Melise M. Edwards (11405780)

“…OT and CL 316243 alone reduced body weight by 7.8 ± 1.3% (P < 0.05) and 9.1 ± 2.1% (P < 0.05), respectively, but the combined treatment produced more pronounced weight loss (15.5 ± 1.2%; P < 0.05) than either treatment alone. These effects were associated with decreased adiposity, adipocyte size, energy intake and increased uncoupling protein 1 (UCP-1) content in epididymal white adipose tissue (EWAT) (P < 0.05). …”

Data_Sheet_1_Physical Exercise Exacerbates Acute Kidney Injury Induced by LPS via Toll-Like Receptor 4.PDF by Talita Guerreiro Rodrigues Húngaro (9133691)

“…</p><p>Methods: C57BL/6J male mice, 12 weeks old, were distributed into four groups: (1) sedentary (control, N = 7); (2) sedentary + LPS (N = 7); (3) trained (N = 7); and (4) trained + LPS (N = 7). …”

Low- and High-Volume of Intensive Endurance Training Significantly Improves Maximal Oxygen Uptake after 10-Weeks of Training in Healthy Men by Arnt Erik Tjønna (416233)

“…<div><p></p><p>Regular exercise training improves maximal oxygen uptake (VO_2max), but the optimal intensity and volume necessary to obtain maximal benefit remains to be defined. A growing body of evidence suggests that exercise training with low-volume but high-intensity may be a time-efficient means to achieve health benefits. …”

Kinases are recruited to the signaling complex by alternative N-t localization domains. by Paloma M. Sato (672126)

“…In most cases, mutations that disrupt specific recruitment interactions decrease pathway activation between 40%–50%. MUT Ste20[N]-Ste50[C] might still localize to the signaling complex, as Ste50's RA domain binds Cdc42 independently of Ste20's PBD domain <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002012#pbio.1002012-Truckses1" target="_blank">[53]</a>. …”

Effect of SARS-CoV-2 Infection and Infection Severity on Longer-Term Glycemic Control and Weight in People With Type 2 Diabetes by Rachel Wong (5544899)

Status of peritubular myoid cells in <i>Wt1</i>^SC-cKO testis during fetal mouse testis development. by Qing Wen (808516)

“…Each bar is a mean±SEM of <i>n</i> = 3 mice. *, <i>P</i><0.05; **, <i>P</i><0.01.…”

Data_Sheet_1_Immediate and long-term electrophysiological biomarkers of antidepressant-like behavioral effects after subanesthetic ketamine and medial prefrontal cortex deep brain... by Matthew Bergosh (18854590)

“…</p>Results<p>We found that the depression-like behavioral and weight effects of CORT correlated with a decrease in aperiodic-adjusted theta power (5–10 Hz) and an increase in sample entropy during the administration phase, and an increase in theta peak frequency and a decrease in the aperiodic exponent once the depression-like phenotype had been induced. …”

The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type... by Klara R. Klein (1973449)

“…In both Part 1 and 2, participants were randomized to TTP399 800 mg or matched placebo (fully blinded) and treated for 12-weeks. …”

Table_1_Long-Lasting Rituximab-Induced Reduction of Specific—But Not Total—IgG4 in MuSK-Positive Myasthenia Gravis.DOCX by Mariapaola Marino (784475)

“…<p>The use of rituximab (RTX), an anti-CD20 monoclonal antibody (Ab), in refractory myasthenia gravis (MG) is associated with a better response in patients with Abs to the muscle-specific tyrosine kinase (MuSK) than in other MG subgroups. …”

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age by Delio Eulalio Martins (5759282)

“…</p><p>Results</p><p>The old-aged group showed a decrease in content of sulphated and non-sulphated glycosaminoglycans relative to middle-aged and there were also alterations in the proportion of GAG disaccharides and a decrease of collagen fiber size. …”

Donor and Geometry Optimization: Fresh Perspectives for the Design of Polyoxometalate Charge Transfer Chromophores by Bethany R. Hood (20396768)

Decoding biomass recalcitrance: Dispersion of ionic liquid in aqueous solution and efficient extraction of lignans with microwave magnetic field by Yu Xia (8822)

“…The optimum hydrolysis conditions were 0.2 g of ionic liquid catalyst per 5.0 g of <i>S</i>. <i>chinensis</i> fruits, a microwave irradiation power of 600 W, and heating time of 12 min, which gave a yield of free-state biphenyl cyclooctene lignans of 4.12±0.37 mg g⁻¹. …”

Brivanib inhibits liver fibrosis induced by thioacetamide. by Ikuo Nakamura (548298)

“…(B) The number of bands of bridging fibrosis per high power field were counted in images obtained at 100× magnification after Sirius red staining. There was a significant decrease in the number of bands in both the 25 mg/kg and 50 mg/kg brivanib groups, compared to placebo. …”

Collagen XVI overexpression leads to an increase of ILK/kindlin-1 interaction. by Konstanze B. Bedal (513309)

“…<p>(<b>A</b>) Proximity ligation assay for the analysis of ILK/kindlin-1 interaction in COLXVI and mock control cells (scale bar equals 50 µm). …”

Influence of Experimental Thermal Shifts and Overcrowding on Fecundity in Wild Females of Acartia Tonsa of the Bahía Blanca Estuary by Berasategui Anabela Anahi (10476259)

“…We examined the influence of thermal shift (6 ± 1ºC and 18 ± 1ºC) and overcrowding stress on egg production and hatching success in wild females of A. tonsa of the Bahía Blanca Estuary. Egg production rate (EP), hatching success during seven days (E7 %) and time taken to hatch 50 % of eggs (T 50) were registered. …”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Furthermore this increase in [Ca²⁺]_c is associated with a reduction in ΔΨ_m. Application of 50 mM KCl induces a further rise in [Ca²⁺]_c and profound mitochondrial depolarisation. …”

How Stable Are 2H-MoS₂ Edges under Hydrogen Evolution Reaction Conditions? by Nawras Abidi (9089558)

“…Hence, we suggest that the 50%S S-edge evolves over time toward a 0%S S-edge, covered by surface OH that will block permanently the active sites.…”

Dose-response effects for 30 minutes luminal histamine treatment. by Qianru Zhang (292683)