An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing by Raymond W. Wong (8463498)

“…<div><p>The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC₅₀: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”

Investigation of optimal charging locations for electric vehicles in Istanbul by Atilgan, B.

“…Electric vehicles have a great potential to decrease the adverse effects of transportation, especially in metropolitan cities. …”
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Assessment of participation bias in cohort studies: systematic review and meta-regression analysis by Sérgio Henrique Almeida da Silva Junior (12739578)

“…Among the 2,964 initially identified, 50 were selected. The average proportion of participation was 64.7%. …”

Luxol Fast Blue myelin stain. by Nathan K. Evanson (5204585)

“…There is a subjective decrease in the intensity of staining in the optic tract of TBI animals, 7 days after injury. …”

Determinants of sensitivity of TRAIL-induced cell death. by Paul Michael Loriaux (383905)

“…The abundance of cleaved PARP for each model has been normalized to the maximum observed abundance. For each model, for a particular dose of TRAIL, the time at which PARP is 50% cleaved is indicated by the dashed red lines. …”

Expression of EMT Markers in Small Airway Walls Exposed to wood smoke. by Yimin Zou (542562)

“…Although the airway epithelium in rats exposed to WS did not show a marked decrease in E-cadherin immunostaining compared to controls, the positive staining of mesenchymal markers (FSP1, vimentin, α-SMA) was sometimes observed in the small airway epithelium at 7 months. …”

Analysis of the 3-Glycidoxypropyltrimethoxysilane (GPTMS) hydrolysis by infrared spectroscopy by Cézar Augusto Casagrande (6072413)

“…In this way, the hydrolysis of 3-Glycidoxypropyltrimethoxysilane (GPTMS) was studied as a function of the hydrolysis time in solutions with 50% of alcoholic solvents by infrared spectroscopy. …”

Binaphthoquinones inhibit yeast respiratory growth by depolarizing the mitochondrial membrane. by Ashkan Emadi (248270)

“…The peak shift toward the left represents a decrease of fluorescence signal of rhodamine 123 in the yeast, indicating the loss of mitochondrial membrane potential in the presence of BiQs as compared to no drug (DMSO) control.…”

Adult MT4-MMP null have subtle abnormalities in the renal papilla. by Manakan B. Srichai (356219)

“…<p>(<b>A–B</b>) No gross abnormalities are seen in low power (50X) images of H and E stained kidneys from MT4-MMP null mice (A) when compared to C57/BL6 controls (B). …”

VEGF knockdown glomerular phenotype. by Delma Veron (151378)

“…<p>(A) PAS stain shows mesangiolysis (arrowhead), microaneurisms (green asterisk) and decreased glomerular volume in VEGF-A knockdown glomeruli, scale bars  = 50 µm. …”

Monitoring of growth and chemotherapy response in the model of visceral growing mPlum HT-29 xenografts. by Henrike Caysa (301868)

“…It becomes apparent that chemotherapy induced a clear decrease of FI indicating the response of tumors. …”

Cannabis craving during the exercise sessions. by Maciej S. Buchowski (129223)

“…Each box represents middle 50% of results and horizontal line inside each box represents median for the score. *- Significant decrease from pre-exercise sessions (P<0.05).…”

Effect of 3-AB treatment on PARP-1 activation and PAR/NeuN, PAR/OX-42 immunocolocalization. by Alexandre Madinier (368860)

“…A marked decrease in PAR formation was observable after 3-AB treatment. …”

Lkb1 deletion in mouse intestinal epithelium does not affect mTOR/S6K pathway. by Boris Y. Shorning (232815)

“…<p>A, B, C, D, Immunohistochemical assay showing no difference in expression of phospho-AMPK-α (Thr172) (A), phospho-mTOR (Ser-2448) (B), phospho-p70 S6 Kinase (Thr421/Ser424) (C), phospho-S6 Ribosomal Protein (Ser 240–244) (D), between induced <i>Cre</i>-negative Lkb1 <i>fl/fl</i> (+/+) and Lkb1-deficient (‘−/−’) samples at day 6. …”

Protective effect of AICAR on the rhodopsin level and OS length during inflammation. by Mamoru Kamoshita (601804)

“…<p>(A, B) Immunoblot analysis. Rhodopsin protein in the retina was decreased during EIU, and this decrease was attenuated by AICAR, 24 hours after LPS injection. …”

CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways-0 by Nathalie Voorzanger-Rousselot (72862)

Phospholipid Mediated Activation of Calcium Dependent Protein Kinase 1 (<em>Ca</em>CDPK1) from Chickpea: A New Paradigm of Regulation by Ajay Kumar Dixit (113592)

The α₁-adrenoceptors in the mouse femoral arterial bed are of the α_1L-subtype. by Joseph Zacharia (420909)

Table_2_Association mapping uncovers maize ZmbZIP107 regulating root system architecture and lead absorption under lead stress.xlsx by Fengxia Hou (13861286)

DataSheet8_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)