Search alternatives:
na decrease » nn decrease (Expand Search), pa decreased (Expand Search), la decreased (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
12 we » 12 wt (Expand Search), 1_ we (Expand Search), 16 we (Expand Search)
na decrease » nn decrease (Expand Search), pa decreased (Expand Search), la decreased (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
12 we » 12 wt (Expand Search), 1_ we (Expand Search), 16 we (Expand Search)
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Discovery of Selective Dopamine Receptor Ligands Derived from (−)-Stepholidine via C‑3 Alkoxylation and C‑3/C‑9 Dialkoxylation
Published 2023“…A C-9 ethoxyl substituent appears optimal for D1R affinity since high D1R affinities were observed for compounds that contain an ethyl group at C-9, with larger C-9 substituents tending to decrease D1R affinity. A number of novel ligands were identified, such as compounds <b>12a</b> and <b>12b</b>, with nanomolar affinities for D1R and no affinity for either D2R or D3R, with compound <b>12a</b> being identified as a D1R antagonist for both G-protein- and β-arrestin-based signaling. …”
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2107
Discovery of Selective Dopamine Receptor Ligands Derived from (−)-Stepholidine via C‑3 Alkoxylation and C‑3/C‑9 Dialkoxylation
Published 2023“…A C-9 ethoxyl substituent appears optimal for D1R affinity since high D1R affinities were observed for compounds that contain an ethyl group at C-9, with larger C-9 substituents tending to decrease D1R affinity. A number of novel ligands were identified, such as compounds <b>12a</b> and <b>12b</b>, with nanomolar affinities for D1R and no affinity for either D2R or D3R, with compound <b>12a</b> being identified as a D1R antagonist for both G-protein- and β-arrestin-based signaling. …”
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2108
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2109
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2110
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2111
Data_Sheet_1_Concerted suppressive effects of carisbamate, an anti-epileptic alkyl-carbamate drug, on voltage-gated Na+ and hyperpolarization-activated cation currents.docx
Published 2023“…However, CRS strongly decreased the strength (i.e., Δarea) of the nonlinear window component of I<sub>Na</sub> (I<sub>Na(W)</sub>), which was activated by a short ascending ramp voltage (V<sub>ramp</sub>); the subsequent addition of deltamethrin (DLT, 10 μM) counteracted the ability of CRS (100 μM, continuous exposure) to suppress I<sub>Na(W)</sub>. …”
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2112
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2113
Screening Mammography Changes for Women 50–74 and ≥75.
Published 2015“…New recommendations were not associated with changes for women age 50–74, but were associated with decreased screening for ≥75, while the Affordable Care Act was associated with increased screening among women age 50–74 and no changes for ≥75.…”
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2114
Activation of axonal GABA<sub>A</sub> receptors decreases AP-induced Ca<sup>2+</sup> transients.
Published 2014“…<p>A, Left, projection of 2-photon fluorescence images of a recorded pyramidal neuron filled with Alexa Fluor 594 (50 µM) and OGB-1 (200 µM). …”
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2115
Loss of primary cilia and decreased nephron number in mice with Tamoxifen-induced <i>Kif3a</i> deficiency.
Published 2013“…(H) Quantitation of the number of cells with a primary cilium. Tamoxifen administration to <i>Kif3a™</i> embryos decreases cilia number by approximately 50% in both ureteric and metanephric mesenchyme cells (***, P<0.001). …”
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2116
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2117
<i>Nf1</i> OPG mice exhibit decreased hole poking in response to a novel holeboard apparatus.
Published 2013“…(C) <i>Nf1</i> OPG mice also showed a trend toward decreased general ambulatory activity although this difference was also not significant (p = 0.053). …”
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2119
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2120