Analyzing the clinical benefit of newer therapies for advanced or metastatic non-small-cell lung cancer: application of the ESMO-magnitude of clinical benefit scale v1.1 by Ricardo García-Fumero (11042247)

“…</p> <p>ESMO-MCBS scores were calculated for 42 positive clinical trials. 54.8% met the ESMO-MCBS thresholds for clinically meaningful benefit (final grade of 4 or 5). That percentage decreased to 40.5% when considering the point estimate of the HR. 50.0% of the trials had no published scorecard on the ESMO website and discrepancies affected 11 (26.2%) studies.…”

Upshift of Phase Transition Temperature in Nanostructured PbTiO₃ Thick Film for High Temperature Applications by Jungho Ryu (1587565)

“…First-principles calculations combined with electron energy loss spectroscopy (EELS) and structural analysis indicate that the film is composed of nano size grains with slightly decreased tetragonality. There is no severe off-stoichiometry, but a high compressive in-plane residual stress was observed in the film along with a high transition temperature and piezoelectric response. …”

Table_3_Bt GS57 Interaction With Gut Microbiota Accelerates Spodoptera exigua Mortality.XLS by Yazi Li (4162948)

“…In addition, we found that B. thuringiensis can cause a dynamic change in the gut microbiota of S. exigua, with a significant reduction in bacterial diversity and a substantial increase in bacterial load. …”

Table_1_Bt GS57 Interaction With Gut Microbiota Accelerates Spodoptera exigua Mortality.XLS by Yazi Li (4162948)

“…In addition, we found that B. thuringiensis can cause a dynamic change in the gut microbiota of S. exigua, with a significant reduction in bacterial diversity and a substantial increase in bacterial load. …”

Data_Sheet_1_Long-Term Aortic Remodeling After Thoracic Endovascular Aortic Repair of Acute, Subacute, and Chronic Type B Dissections.docx by Zhenjiang Li (1448203)

“…</p>Results<p>After TEVAR, the true lumen (TL) dimension increased and the false lumen (FL) dimension decreased or did not change over a 5-year follow-up period in all three temporal groups. …”

Image_2_Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy.pdf by Sini Sunny (12864302)

“…<p>Nuclear factor erythroid 2-related factor 2 (NRF2), a redox sensor, is vital for cellular redox homeostasis. …”

<i>pnt</i>^<i>aga</i> does not affect PGC numbers in embryonic gonads. by Alicia E. Rosales-Nieves (22120513)

“…Scale bars: 50 μm. Related to <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011809#pgen.1011809.g003" target="_blank">Fig 3</a>.…”

Light-Driven Bending Crystals of Salicylidenephenylethylamines in Enantiomeric and Racemate Forms by Hideko Koshima (1825630)

“…The reversible bending of the achiral enol-(<i>rac</i>)-<b>1</b> crystal could be repeated over 100 times, while the tip displacement angles of the chiral enol-(<i>S</i>)-<b>1</b> and enol-(<i>R</i>)-<b>1</b> crystals gradually decreased with repeated cycles. In situ X-ray measurements revealed that the bending motion of the chiral and achiral crystals was caused by a slight shrinkage of the <i>a</i> and <i>b</i> axes of the unit cell, respectively, corresponding to the long axis of the platelike crystals; shrinkage was induced by the shape change of component salicylidenephenylethylamine molecules upon photoinduced proton transfer. …”

DataSheet_1_Identification of natural killer markers associated with fatal outcome in COVID-19 patients.pdf by Nadine Tarantino (458066)

“…Introduction<p>Increasing evidence has shown that coronavirus disease 19 (COVID-19) severity is driven by a dysregulated immunological response. Previous studies have demonstrated that natural killer (NK) cell dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of NK cell markers as a driver of death in the most critically ill patients.…”

Table_3_Alterations in the Gut Microbiome of Individuals With Tuberculosis of Different Disease States.xlsx by Yue Wang (65477)

“…The purpose of the current study was to explore the alterations in gut microbiome under different tuberculosis disease stages in the Uyghur population, clarify the composition of microbial taxonomy, search for microbial biomarkers and provide innovative ideas for individual immune prevention and for control strategies.</p>Design<p>A case–control study of Uyghur individuals was performed using 56 cases of pulmonary tuberculosis (PTB), 36 cases of latent tuberculosis infection (LTBI) and 50 healthy controls (HC), from which stool samples were collected for 16S rRNA gene sequencing.…”

Table_1_Uncertainty in coprophilous fungal spore concentration estimates.DOCX by Angelina G. Perrotti (14292716)

“…Finally, the probability of encountering a CFS spore from a specific taxon occurring in moderate concentrations (1,000 spores/unit²) dramatically decreases after a low tracer count (∼50). …”

Image_5_Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model.TIF by María Teresa Soto-Navarrete (3202896)

“…<p>Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. …”

Image_1_Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model.TIF by María Teresa Soto-Navarrete (3202896)

“…<p>Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. …”

Impact of case/control ratio misspecification on sample size inference. by Hanna Julienne (469265)

“…<p>We simulated 1,000 replicates including 50,000 individuals. For each individual we generated a disease status assuming a prevalence of 25% and an independent genotype <b><i>G</i></b> with frequency randomly sampled in [0.001, 0.999]. …”

Light-Driven Bending Crystals of Salicylidenephenylethylamines in Enantiomeric and Racemate Forms by Hideko Koshima (1825630)

“…The reversible bending of the achiral enol-(<i>rac</i>)-<b>1</b> crystal could be repeated over 100 times, while the tip displacement angles of the chiral enol-(<i>S</i>)-<b>1</b> and enol-(<i>R</i>)-<b>1</b> crystals gradually decreased with repeated cycles. In situ X-ray measurements revealed that the bending motion of the chiral and achiral crystals was caused by a slight shrinkage of the <i>a</i> and <i>b</i> axes of the unit cell, respectively, corresponding to the long axis of the platelike crystals; shrinkage was induced by the shape change of component salicylidenephenylethylamine molecules upon photoinduced proton transfer. …”

Table_2_Bt GS57 Interaction With Gut Microbiota Accelerates Spodoptera exigua Mortality.XLS by Yazi Li (4162948)

“…In addition, we found that B. thuringiensis can cause a dynamic change in the gut microbiota of S. exigua, with a significant reduction in bacterial diversity and a substantial increase in bacterial load. …”

Table_1_Uncertainty in coprophilous fungal spore concentration estimates.DOCX by Angelina G. Perrotti (14292716)

“…Finally, the probability of encountering a CFS spore from a specific taxon occurring in moderate concentrations (1,000 spores/unit²) dramatically decreases after a low tracer count (∼50). …”

Data_Sheet_1_Resveratrol Improves Growth Performance, Intestinal Morphology, and Microbiota Composition and Metabolism in Mice.docx by Yu Zhuang (2824982)

“…The current study was conducted to explore whether RSV alleviates weaning stress through improving gut health in a weaning mouse model. Forty 21-day-old weaned mice were randomly assigned to a control group without RSV treatment and three treatment groups with 10, 20, and 50 mg/kg RSV for 28 days.…”

Table_1_Next generations of CAR-T cells - new therapeutic opportunities in hematology?.docx by Jaromir Tomasik (14022519)

“…All registered treatments and most clinical trials are based on so-called 2nd generation CARs, which consist of an extracellular antigen-binding region, one costimulatory domain, and a CD3z signaling domain. Unfortunately, despite remarkable overall treatment outcomes, a relatively high percentage of patients do not benefit from CAR-T therapy (overall response rate varies between 50 and 100%, with following relapse rates as high as 66% due to limited durability of the response). …”

Data_Sheet_1_Enterovirus 71 Suppresses miR-17-92 Cluster Through Up-Regulating Methylation of the miRNA Promoter.docx by Yuxuan Fu (4437475)

“…The methylation of the miR-17-92 promoter was significantly increased (50%) upon EV71 infection, which appeared to be caused by the increased expression of DNMT3B but not DNMT1 and DNMT3A. …”