DataSheet_1_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Image_3_Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells.TIF by Yating Chen (6707360)

“…Application of Allicin 30 μM reduced the late sodium current (I_Na,L) of the Nav1.5 channel current encoded by ΔKPQ-SCN5A from 1.92 ± 0.12 to 0.65 ± 0.03 pA/pF (P < 0.01, n = 15), which resulted in the decrease of I_Na,L/I_Na,P (from 0.94% ± 0.04% to 0.32% ± 0.02%). …”

Image_7_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_4_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Video_3_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.mov by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Effects of different production rates, penetrances and administration times of A3G^ΔVif on HIV growth curve. by Iraj Hosseini (184245)

“…<p>In all the simulations, 500,000 cells were inoculated by 1 ng 24 WT HIV input. (A–D) A3G^ΔVif with different production rates were administered right after inoculation. …”

mRNA Secondary Structures Can Explain Experimental Observations by Michael Hiller (11282)

“…<div><p>(A) A structural change explains exon skipping by the 25G->A mutation in the human <i>CFTR</i> exon 12<b>.</b> NI scores [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030204#pgen-0030204-b036" target="_blank">36</a>] for the wild-type (wt) and the 25G->A mutation (highlighted gray) indicate the strength of ESE (blue, positive score) and ESS (red, negative score) motifs. …”

Image_6_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Image_4_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Video_1_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.mov by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_1_Condensed Tannins in White Clover (Trifolium repens) Foliar Tissues Expressing the Transcription Factor TaMYB14-1 Bind to Forage Protein and Reduce Ammonia and Methane Emis... by Marissa B. Roldan (7023566)

“…However, the transformation of white clover with the TaMYB14-1 transcription factor from Trifolium arvense has resulted in the production of CTs in leaves up to 1.2% of dry matter (DM). In this study, two generations of breeding elevated foliar CTs to >2% of DM. …”

Image_4_Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells.TIF by Yating Chen (6707360)

“…Application of Allicin 30 μM reduced the late sodium current (I_Na,L) of the Nav1.5 channel current encoded by ΔKPQ-SCN5A from 1.92 ± 0.12 to 0.65 ± 0.03 pA/pF (P < 0.01, n = 15), which resulted in the decrease of I_Na,L/I_Na,P (from 0.94% ± 0.04% to 0.32% ± 0.02%). …”

Video_5_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.mov by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Video_4_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.mov by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_5_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

The importance of the adaptive threshold. by Jorge F. Mejias (228294)

Fig 4 - by Samuel Thomas (6001970)

“…Volcano plots show 3079 and 2658 total <i>m/z</i> features, respectively; enlarged dots indicate significantly modulated features (Student’s <i>t</i>-test <i>p</i>-value < 0.05 and fold-change ≥ 50%); red indicates increase with JC virus, green indicates decrease with JC virus. …”

siRNAs targeting IDH1. by Xi Chen (35903)

“…Two good siRNAs (-G-) and three bad siRNAs (-B-) are designed to target the IDH1 gene; all of them decrease the target gene expression by about 50%. (B–E) The relative expression levels of off-target genes predicted by Picky. …”

SIRT1 regulates the maintenance of the dendritic tree. by Juan F. Codocedo (304388)

“…Neurons were fixed at 14 DIV and immunostained against Tau protein. (<b>A</b>) Representative images of Tau immunodetection in trasfected GFP positive neurons. …”

Laccase-catalyzed iodination of different mono-methoxy-substituted phenolic compounds (structures: see Figure 2). by Julian Ihssen (417694)

“…a<p>Reaction conditions: 4 mM educt, 50 mM potassium iodide, 100 µM ABTS and 0.25 mg mL⁻¹<i>T. versicolor</i> laccase, % conversion was calculated as the relative decrease in educt peak area compared to enzyme-free control reactions.…”