The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes. حسب Al-Asmakh, Maha

"…The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. …"
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Local supersaturation and the growth of protective scales during CO2 corrosion of steel: Effect of pH and solution flow حسب Sk, Mobbassar Hassan

"…We show that siderite is the first crystalline product and that chukanovite follows, with a delay time that decreases with increasing pH. …"
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Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome. حسب Thirumal Kumar, D

"…In the simulations, we observed decreased deviation and fluctuations in native NOD2, whereas decreased compactness and inter- and intramolecular hydrogen bonds were observed in the W490L mutant. …"
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Co-doped zigzag graphene nanoribbon based gas sensor for sensitive detection of H2S: DFT study حسب Salih, Ehab

"…In this work, we present a highly sensitive gas sensor for the detection of poisonous hydrogen sulfide gas (H2S) based on copper and zinc co-doped zigzag graphene nanoribbon (Cu/Zn-ZGNR). …"
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Conjugated Linoleic Acid (CLA) co-treatment alleviates antidiabetic drug, rosiglitazone associated deterioration of bone remodeling حسب Ibrahim, Khadega

"…Compared to RSG group, the combined treatment group stimulates osteoblastogenesis, as evidenced by increased mineralization and upregulation of osteogenic markers OPN and RUNX2 and inhibits adipogenesis in osteogenic media as showed by decreased lipid content and downregulation of adipogenic markers FABP4, LPL and adipsin. …"
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Aqueous Extract Of Origanum Syriacum Inhibits Proliferation, Migration, Adhesion As Well As Erk1/2 Phosphorylation In Aggressive Breast Cancer حسب Al Kahlout, Amal

"…Moreover, preliminary results indicate that OSE decreased ERK1/2 phosphorylation in MDA-MB-231 cells. …"
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Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress حسب Fatima, Munazza T

"…We found that SESN2 silencing, though did not specifically induce ER stress, it aggravated the effects of thapsigargin-induced ER stress on oxidative stress and cell survival. …"
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Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach. حسب Thirumal Kumar, D

"…From the simulation studies, we observed higher deviation, lower protein compactness, and a decrease in the number of intramolecular hydrogen bonds in the mutant W764C MSH2-MSH6 protein complex. …"
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Micromodel Study on Colloid Retention and Mobilization under different Geo-Chemical Conditions during Single and Two-Phase Flow حسب Nishad, Safna

"…Micromodels are analogs to porous media that allow the real-time visualization of pore-scale processes that occur at highly controllable physio-chemical conditions in the laboratory scale. In this thesis, we used a glass micromodel with representative geometry to observe the pore-scale mechanisms during colloid retention and mobilization experiments in a saturated and unsaturated porous media. …"
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Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes حسب Abushanab, Dina

"…AimsInsufficient risk factor control can lead to a loss of millions of productivity-adjusted life years (PALYs). We aimed to assess the productivity burden of cardiovascular disease (CVD) in type 2 diabetes (T2D) and examine the potential advantages of enhancing the control of modifiable CVD risk factors in Qatar. …"
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. حسب Akhtar, Sabah

"…SNG treatment of MM cells leads to down-regulation of the anti-apoptotic proteins including cyclin D, Bcl-2, Bclxl, and XIAP. In addition, it also upregulates pro-apoptotic protein, Bax. …"
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Work-from-home, electricity, and water: Evidence from COVID-19 in Qatar حسب Bernstein, David H.

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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …"
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Characterization of polysulfone/diisopropylamine 1-alkyl-3-methylimidazolium ionic liquid membranes: high pressure gas separation applications حسب Khraisheh M.

"…In our previous study, we proved the enhanced ability of ionic liquid enhanced PSF for the separation of CO2 from gas streams. …"
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Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach. حسب Agrahari, Ashish Kumar

"…Therefore, in this study, we used 200 ns molecular dynamic simulation using the GROMACS 5.1.4 package software to investigate the impact of the G2019S substitution on the structure of the kinase domain of LRRK2. …"
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Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway حسب Sampath, Chethan

"…Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the main precursors of AGEs and N(e)-(carboxymethyl)lysine (CML) found to be predominantly higher in the diabetic population. We hypothesized that phloretin from apple and [6]-gingerol from ginger inhibit formation of AGEs and suppress the receptor for advanced glycation end products (RAGE) via nuclear factor erythroid-2- related-factor-2 (Nrf2)-dependent pathway. …"
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Sulforaphane reduces obesity by reversing leptin resistance. حسب Çakır, Işın

"…Here, we show that the natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia. …"
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Effect of zirconia nanotube coating on the hydrophilicity and mechanochemical behavior of zirconium for biomedical applications حسب Nezhad, Erfan Zal

"…Zirconium has attracted considerable attention in the biomedical field owing to its biocompatibility and desirable tribological and mechanical properties. In this study, we anodized pure zirconium in an ammonium fluoride and ethylene glycol electrolyte, which produced a coating of ZrO2 nanotubes (NTs). …"
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Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity حسب Sampath, Chethan

"…Abstract Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would mitigate AGEs formation via activating the nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway in a mouse model of high fat diet-induced obesity. …"
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Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells حسب Kuttikrishnan, Shilpa

"…Thiostrepton led downregulation of FoxM1 accompanied by decreased expression of Aurora kinase A, B, matrix metalloproteinases, and oncogene SKP2 as well as MTH1. …"
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