Joule heating of the brain tissue during the application of pulsed electric fields for e-biopsy. by Ilai Genish (12569114)

“…Panels <b>a-c</b> show the simulation for high voltage, short-duration protocol: 40 pulses 1000 V, 40 μs, 4 Hz, coupled with the simulation for low voltage, long-duration protocol: 40 pulses 50 V, 15 ms, delivered at 4 Hz. …”

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent <i>STAG2</i> Mutation by Andrew S. Brohl (596305)

“…We report here the largest genomic survey to date of 101 EFT (65 tumors and 36 cell lines). Using a combination of whole genome sequencing and targeted sequencing approaches, we discover that EFT has a very low mutational burden (0.15 mutations/Mb) but frequent deleterious mutations in the cohesin complex subunit <i>STAG2</i> (21.5% tumors, 44.4% cell lines), homozygous deletion of <i>CDKN2A</i> (13.8% and 50%) and mutations of <i>TP53</i> (6.2% and 71.9%). …”

Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance - Fig 7 by Helen E. McNeil (8190873)

“…Data presented are the mean of three independent biological replicates and are shown as the time taken for the fluorescence to decrease by 50% +/- SE. Data were analysed by one way ANOVA. …”

Mosquito-Disseminated Pyriproxyfen Yields High Breeding-Site Coverage and Boosts Juvenile Mosquito Mortality at the Neighborhood Scale by Fernando Abad-Franch (127663)

“…</p><p>Methodology/Principal Findings</p><p>We conducted a four-month trial within a 20-month study to investigate mosquito-driven dissemination of PPF dust-particles from 100 ‘dissemination stations’ (DSs) deployed in a 7-ha sub-area to surveillance dwellings and sentinel breeding sites (SBSs) distributed over an urban neighborhood of about 50 ha. …”

The impact of excessive DNA amounts used for bisulfite conversion on the amplification efficiency and the methylation level of <i>LINE-1</i> and <i>Alu</i>. by Trang Thi Quynh Tran (20485595)

“…(<b>D, E</b>) An increase in methylation level of <i>LINE-1</i> (D) and <i>Alu</i> (E) was associated with a decrease in DNA input for bisulfite conversion. …”

Temperature dramatically modulates the expression of the pigmentation gene <i>tan</i> in posterior abdominal epidermes of females. by Jean-Michel Gibert (68707)

“…(B) Quantification of pigmentation gene expression in posterior abdomen epidermes (segments A5, A6 and A7) from female <i>w</i>^<i>1118</i> pharates (left) and young <i>w</i>^<i>1118</i> adult females (right) grown at 18°C or 29°C (pools of 50 epidermes for pharates and 30 epidermes for adults, n = 3, error bars: standard deviations; gene expression at 18°C has been normalized on gene expression at 29°C). …”

Data_Sheet_1_Ambient Temperature Is Correlated With the Severity of Neonatal Hypoxic-Ischemic Brain Injury via Microglial Accumulation in Mice.PDF by Rika Zen (12509164)

“…The mice were subsequently subjected to 10% hypoxic exposure for 50 min at 36.0, 36.5, or 37.0°C. A control group was also included in the study. …”

Data_Sheet_1_Effect of epidural spinal cord stimulation on female sexual function after spinal cord injury.docx by Claire Shackleton (13369920)

“…Sexual distress was reduced by 55%, with a mean decrease of 12 points (55.4%) from baseline (21.7 ± 17.2) to post-intervention (9.7 ± 10.8). …”

Neurite degeneration following si<i>Nmnat2</i> injection precedes loss of neuronal viability. by Jonathan Gilley (126469)

“…<p>(A) Viability of wild-type SCG neurons injected with non-targeting siRNA (si<i>Control</i>) or <i>Nmnat2</i> siRNA (si<i>Nmnat2</i>), together with pEGFP-C1 (10 ng/µl), and treated with 50 µM z-VAD-fmk or vehicle (DMSO) as indicated. …”

Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells and in xenografts: Identification of apoptotic genes as targets for demethylation-2 by Khaldoun Al-Romaih (79731)

“…</p><p></p>n is the Mean of tumor volumes measured in 12 xenograft tumors. There was a significant decrease (p < 0.05) in tumor volumes as a result of decitabine treatment. , Osteoid assessment . …”

Data_Sheet_1_Whole Body Vibration Improves Spatial Memory, Anxiety-Like Behavior, and Motor Performance in Aged Male and Female Rats.pdf by Tamás Oroszi (11983592)

“…WBV-treated rats showed a decrease in their anxiety level in the open field test compared with those in the pseudo-treated controls. …”

2′-<em>O</em> Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo by Kristy J. Szretter (165885)

“…In comparison, WNV-E218A was virulent after intracranial infection as judged by increased infection in different regions of the central nervous system (CNS) and a greater than 16,000-fold decrease in LD₅₀ values in <em>Ifit1</em>^−/− compared to wild type mice. …”

Durability of Triple Combination Therapy Versus Stepwise Addition Therapy in Patients With New-Onset T2DM: 3-Year Follow-up of EDICT by Muhammad Abdul-Ghani (4707436)

“…Thus, the difference in HbA1c between the two treatment groups at 3 years was 0.50% (95% CI=0.39-0.61, P<0.0001). …”

The Effect of Aerobic Exercise on Intrahepatocellular and Intramyocellular Lipids in Healthy Subjects by Andrea Egger (107540)

“…Two hours aerobic exercise resulted in a significant decrease in IMCL (−22.6±3.3, % from baseline) and increase in IHCL (+34.9±7.6, % from baseline). …”

Spiking activity of dentate gyrus granule cells during exploratory behaviour evokes large short-term plasticity at mossy fiber synapses <i>in vitro</i>. by Anja Gundlfinger (366062)

“…A large dynamic range of response amplitudes is apparent with amplitudes generally largest with ISIs ranging from 50–1000 ms. …”

DataSheet1_The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells.ZIP by Hai-Ling Gao (9501677)

“…However, MK-2206 (0.3 and 1 μM) significantly increased the anticancer efficacy of mitoxantrone, SN-38 and topotecan, in H460/MX20 and S1-M1-80 cancer cells, as indicated by a significant decrease in their IC50 values, compared to cells incubated with vehicle. …”

Image_3_The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress.jpeg by Trevor J. Buhr (10191398)

“…To that end, young adult male rats were exposed to a single episode of 0, 50, or 100 uncontrollable tail shocks and then given free access to running wheels for 9 weeks. …”

Image_4_STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.TIF by Simon J. Houtman (8716335)

“…EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. …”

C6-ceramide nanoliposomes target GAPDH in CLL. by Lindsay K. Ryland (499850)

“…Densitometry analysis from replicate experiments (n=4) was performed via ImageJ software. In Figure A(ii) the representative blot demonstrates a decrease in GAPDH at 12.5µM C6-ceramide, a result not observed in the other two distinct replicate experiments. * <i>P</i> < 0.05; ** <i>P <0 .005</i>. …”

Image_4_Genome-Wide Patterns of Population Structure and Linkage Disequilibrium in Farmed Nile Tilapia (Oreochromis niloticus).jpg by Grazyella M. Yoshida (5030351)

“…No differences were observed in the LD decay among populations, with a rapid decrease of r² with increasing inter-marker distance. …”