Showing 1,101 - 1,120 results of 47,960 for search '(( 50 ((na decrease) OR (((nn decrease) OR (a decrease)))) ) OR ( 12 we decrease ))', query time: 0.82s Refine Results
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    Discovery of Selective Dopamine Receptor Ligands Derived from (−)-Stepholidine via C‑3 Alkoxylation and C‑3/C‑9 Dialkoxylation by Hari K. Namballa (13363787)

    Published 2023
    “…A C-9 ethoxyl substituent appears optimal for D1R affinity since high D1R affinities were observed for compounds that contain an ethyl group at C-9, with larger C-9 substituents tending to decrease D1R affinity. A number of novel ligands were identified, such as compounds <b>12a</b> and <b>12b</b>, with nanomolar affinities for D1R and no affinity for either D2R or D3R, with compound <b>12a</b> being identified as a D1R antagonist for both G-protein- and β-arrestin-based signaling. …”
  6. 1106

    Discovery of Selective Dopamine Receptor Ligands Derived from (−)-Stepholidine via C‑3 Alkoxylation and C‑3/C‑9 Dialkoxylation by Hari K. Namballa (13363787)

    Published 2023
    “…A C-9 ethoxyl substituent appears optimal for D1R affinity since high D1R affinities were observed for compounds that contain an ethyl group at C-9, with larger C-9 substituents tending to decrease D1R affinity. A number of novel ligands were identified, such as compounds <b>12a</b> and <b>12b</b>, with nanomolar affinities for D1R and no affinity for either D2R or D3R, with compound <b>12a</b> being identified as a D1R antagonist for both G-protein- and β-arrestin-based signaling. …”
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  10. 1110

    Data_Sheet_1_Concerted suppressive effects of carisbamate, an anti-epileptic alkyl-carbamate drug, on voltage-gated Na+ and hyperpolarization-activated cation currents.docx by Te-Yu Hung (15861305)

    Published 2023
    “…However, CRS strongly decreased the strength (i.e., Δarea) of the nonlinear window component of I<sub>Na</sub> (I<sub>Na(W)</sub>), which was activated by a short ascending ramp voltage (V<sub>ramp</sub>); the subsequent addition of deltamethrin (DLT, 10 μM) counteracted the ability of CRS (100 μM, continuous exposure) to suppress I<sub>Na(W)</sub>. …”
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  12. 1112

    A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization-5 by Chandrashekhar D Kamat (60176)

    Published 2011
    “…<p><b>Copyright information:</b></p><p>Taken from "A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization"</p><p>BMC Cardiovascular Disorders 2007;7():4-4.…”
  13. 1113

    Activation of axonal GABA<sub>A</sub> receptors decreases AP-induced Ca<sup>2+</sup> transients. by Yang Xia (104600)

    Published 2014
    “…<p>A, Left, projection of 2-photon fluorescence images of a recorded pyramidal neuron filled with Alexa Fluor 594 (50 µM) and OGB-1 (200 µM). …”
  14. 1114
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    Loss of primary cilia and decreased nephron number in mice with Tamoxifen-induced <i>Kif3a</i> deficiency. by Lijun Chi (196000)

    Published 2013
    “…(H) Quantitation of the number of cells with a primary cilium. Tamoxifen administration to <i>Kif3a™</i> embryos decreases cilia number by approximately 50% in both ureteric and metanephric mesenchyme cells (***, P<0.001). …”
  16. 1116

    A-p50 affects tumor cell survival through inhibition of NF-κB-mediated transcriptional activation by Jing Mi (18654)

    Published 2011
    “…</p><p>© 2006 The Author(s)</p> () MTT assay of cell viability. Ad-A-p50-infected A549 cells show a significant decrease in cell viability (Ad-A-p50) compared to Ad-siNT-infected cells, = 3–5 per group, = 0.0001. () Hoechst 33342 staining of apoptotic nuclei. …”
  17. 1117

    <i>Nf1</i> OPG mice exhibit decreased hole poking in response to a novel holeboard apparatus. by David F. Wozniak (78177)

    Published 2013
    “…(C) <i>Nf1</i> OPG mice also showed a trend toward decreased general ambulatory activity although this difference was also not significant (p = 0.053). …”
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