Image_6_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_7_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_3_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_2_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Data_Sheet_1_Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States.pdf by Ning Cao (158319)

Gene expression profiles in wildtype and <i>Tnfr1,2-</i>deficient glomeruli after TNF stimulation ex vivo. by Anela Taubitz (433585)

“…<p>Expression profiling by microarrays was performed on isolated glomeruli from wildtype and <i>Tnfr1,2</i>−/− mice 12 after stimulation with 50 ng/ml TNF for 12 hours ex vivo. A negativ “fold change” (black to green) indicates decreased expression and a postive “fold change” (black to red) indicates increased expression in a glomerular sample compared with the average of all analyzed samples. …”

IL-4 induced CCL26 expression is inhibited by PLAG. by Jinseon Jeong (2579929)

“…<p>(A) A549 cells were treated with various doses of PLAG (1, 5, 10, 50 μg/mL) for 1 h and stimulated with IL-4 (10 ng/mL) for 24 h. …”

Interaction of maytansinoids with MCF7 cells. by Victor S. Goldmacher (691791)

“…The ED₅₀ is a concentration of a maytansinoid that decreased the binding of a trace amount of ³[H]-<i>S</i>-methyl DM1 by 50% in a competition binding assay. …”

AE treatment induces autophagy, and inhibits angiogenesis and Hif-1α expression in xenografted tumors. by Alok De (446321)

“…<p>A. Photograph showing increased immunoexpression of beclin1 in xenografted tumors after being treated with AE. …”

Analysis of Mad2l2 function in fibroblasts. by Mehdi Pirouz (451801)

“…<p>(A) Protein extracts from HA-Mad2l2 transfected NIH3T3 cells were co-immunoprecipitated (IP) by antibodies against G9a, GLP, or IgG (as negative control). …”

Paired t-test comparing standard levels measured on recruitment and at follow-up. by Cherith N. Reid (291365)

Vasorelaxation of small arteries (<150 µm) from 9 month-old GK or Wistar rats is endothelia dependent. by Sachin Gupte (363123)

Effects of TTP2515 on metabolic and calorimetry parameters in leptin-deficient mice. by Roxanne Dutia (418714)

“…(<b>C</b>) Body weight was significantly lower in TTP2515-treated mice on the 50 mg/kg dose. (<b>D</b>) Immediately upon starting the 50 mg/kg dose, mean respiratory quotient was significantly decreased in TTP2515 treated mice during the light cycle. …”

Single fiber connections to FSINs with large EPSP show group I mGluR-dependent LTD. by Viktor Szegedi (134818)

“…Scales 1 nA and 100 pA/5 ms. (A2) Single AP-evoked EPSP amplitude (interval 10 s) in the same experiment at baseline and following the PC 40 Hz burst firing (arrow at 0 time point). …”

DsRNA() delivery for PTGS of expression by Ji Hyun Yang (16591)

“…To evaluate an optimum complex formation, various concentrations of POA were mixed with a fixed concentration of dsRNA () (lane 1, 100 ng of dsRNA only; lanes 2–9, 12.5, 25, 37.5, 50, 62.5, 75, 87.5 and 100 ng of POA mixed with 100 ng of dsRNA, respectively). …”

Chemical structure and properties of screen identified hits. by Simon R. Stockwell (180885)

“…<p><b>A) Compound chemical structures.</b> Compounds are arranged in order of decreasing potency. …”

Effect of MTDH gene overexpression on clinical sensitivity of doxorubicin. by Zhenchuan Song (741160)

“…<b>(</b>F, G) In the MTDH transfected group, the cell cycle measured by FCM and showed a increase in the proportion of cells in the S and G2/M phase and decrease in cells in the G0/G1 phases compared to the untransfected group. …”

Inhibitory effect of sodium nitrite on corrosion of lead in 0.1 M sodium hydroxide solution by Mourad, M.Y.

“…The concentrations of NaNO2 employed are in the range 1-5×10-5. There is a linear relationship between the corrosion potential and the molar concentration of NaNO2. …”
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Dorsal and chinmo mutually influence each other’s expression, driving tumor growth while inhibiting differentiation. by Caroline Dillard (15381444)

“…Insets show a decrease of elav+ (magenta) cells within the tumor upon chinmo^OE. …”