Image4_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…However, it is not clear whether SGLT2 inhibitors have cardiovascular benefits in patients with cancer chemotherapy–related cardiac dysfunction. We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Image2_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…However, it is not clear whether SGLT2 inhibitors have cardiovascular benefits in patients with cancer chemotherapy–related cardiac dysfunction. We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Image5_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…However, it is not clear whether SGLT2 inhibitors have cardiovascular benefits in patients with cancer chemotherapy–related cardiac dysfunction. We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

DataSheet1_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy... by Changzhen Ren (10649432)

“…However, it is not clear whether SGLT2 inhibitors have cardiovascular benefits in patients with cancer chemotherapy–related cardiac dysfunction. We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

DataSheet_1_The neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury in patients with cardiopulmonary bypass.docx by Tuo Pan (9264234)

“…Secondly, a propensity-score matched cohort (sivelestat vs control: 50 vs 50) was performed in these 665 patients. …”

Image3_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…However, it is not clear whether SGLT2 inhibitors have cardiovascular benefits in patients with cancer chemotherapy–related cardiac dysfunction. We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

DataSheet1_Identification of target groups and individuals for adherence interventions using tree-based prediction models.PDF by Johannes Wendl (11213891)

“…</p><p>Results: 1) our simple linear regression model estimated a positive adherence effect, that is an increase in total costs of 10.73 Euro per PDC-point and year for diabetes type 1, 3.92 Euro for diabetes type 2 and 1.92 Euro for hyperlipidemia (all p ≤ 0.001). 2) The model-based tree detected subgroups with negative estimated adherence effects for diabetes type 2 (-1.69 Euro, 24.4% of cohort) and hyperlipidemia (-0.11 Euro, 36.1% and -5.50 Euro, 5.3%). 3) Our model-based random forest estimated personalized adherence effects with a significant proportion (4.2%–24.1%) of negative effects (up to -8.31 Euro). …”

Method for the Large-Scale Synthesis of Multifunctional 1,4-Dihydro-pyrrolo[3,2‑<i>b</i>]pyrroles by Mariusz Tasior (1457731)

“…The conditions identified (first step: toluene/AcOH = 1:1, 1 h, 50 °C; second step: toluene/AcOH = 1:1, Fe­(ClO₄)₃·H₂O, 16 h, 50 °C) resulted in the formation of tetraarylpyrrolo­[3,2-<i>b</i>]­pyrroles in a 6–69% yield. …”

Method for the Large-Scale Synthesis of Multifunctional 1,4-Dihydro-pyrrolo[3,2‑<i>b</i>]pyrroles by Mariusz Tasior (1457731)

“…The conditions identified (first step: toluene/AcOH = 1:1, 1 h, 50 °C; second step: toluene/AcOH = 1:1, Fe­(ClO₄)₃·H₂O, 16 h, 50 °C) resulted in the formation of tetraarylpyrrolo­[3,2-<i>b</i>]­pyrroles in a 6–69% yield. …”

An exemplary co-culture experiment shows that hMSCs can modulate cytokine secretion of THP-1 macrophage-like cells. by Mika Pietilä (332438)

The effector functions of CHK-152 contribute to protection <i>in vivo</i>. by Pankaj Pal (404355)

“…No statistically significant differences between ch-CHK-152 and ch-CHK-152 N297Q were observed with the 25 µg dose. Of note, we observed a reproducible decrease in clinical score on day 5 in many animals. …”

VpsO-503 does not undergo tyrosine trans autophosphorylation <i>in vitro</i>. by Carmen Schwechheimer (9300303)

“…The lack of a second band at a slower migration indicates that we did not observe <i>in trans</i> phosphorylation on the C-terminal tail of the GST-fusion VpsO-503^K551A (catalytically inactive) mutant by the VpsO-503 WT enzyme. …”

FOXL2 recruitment to PML Bodies enhances its transactivation ability. by Adrien Georges (201474)

“…FOXL2 was precipitated using anti-V5-conjugated affinity resin for western blot analysis. Upper panel shows a 50 kDa band detected with anti-FOXL2 antibody. …”

Image_2_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Image_3_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Image_1_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Image_4_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Data_Sheet_1_Repeated Vessel Interactions and Climate- or Fishery-Driven Changes in Prey Density Limit Energy Acquisition by Foraging Blue Whales.docx by Marie Guilpin (9198812)

“…We specifically examined the energetic consequences of a demonstrated reduction in dive duration caused by vessel proximity, and of krill density reductions potentially resulting from krill exploitation or climate change. …”

BX-C genes control DT tube tapering. by Ryo Matsuda (685668)

“…This could be attributed to competition between the overexpressed proteins and endogenous <i>abdA</i> or <i>AbdB</i> [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004929#pgen.1004929.ref046" target="_blank">46</a>], leading to a systemic decrease of tube diameter.…”

Table_2_Association mapping uncovers maize ZmbZIP107 regulating root system architecture and lead absorption under lead stress.xlsx by Fengxia Hou (13861286)