Ascorbic acid enhances demethylation of H3K27me3 and induces <i>Prdm14</i>, <i>Tsix</i>, and <i>Xist</i>. by Yasunao F. Kamikawa (741742)

“…<p>(A) The catalytic domain of Flag-tagged UTX protein was overexpressed in HEK cells, in the presence or absence of ascorbic acid (AA). …”

Data_Sheet_1_The combined impact of redcedar encroachment and climate change on water resources in the Nebraska Sand Hills.docx by Yaser Kishawi (12959564)

“…Four plausible redcedar encroachment scenarios, namely 0.5% (no encroachment), 2.4, 4.6, and 11.9%, were considered in the numerical simulations. We, therefore, built: i) the historical scenario (2000–2019) with the current climate and redcedar cover leading to baseline results; ii) the most-likely future scenario (2020–2099) with projected climate (50^th percentile of aridity index distribution) and redcedar encroachment that was estimated by using a combination of neural network and Markov-chain cellular automata model; iii) 16 future scenarios (2020–2099) with different combinations of extreme climate (5^th and 95^th percentiles of aridity index distribution) and four hypothetical encroachment scenarios (0.5, 2.4, 4.6, and 11.9%). …”

Neutrophil extracellular traps contribute to the pathogenesis of leprosy type 2 reactions by Camila Oliveira da Silva (7365539)

“…The T2R triggering mechanisms and immune-inflammatory pathways involved in its pathology remain ill defined. In a recent report, we defined the recognition of nucleic acids by TLR9 as a major innate immunity pathway that is activated during T2R. …”

Supplementary Figure 1 from Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocar... by Edward J. Kim (14993765)

Stronger evidentiary standards do not reduce the need to publish negative outcomes by Silas Boye Nissen (6815351)

Transcription factor c-Jun activation and cell viability in SH-SY5Y cell line following stimulation with H₂O₂ for 3 h. by Marco Feligioni (287395)

“…Application of D-JNKI1, 30 min prior to H₂O₂ stimulation decreased P-c-Jun activation. Densitometric analysis revealed a fold increase ∼1.60 for 50 and ∼1.80 for 75 mM of P-c-Jun/c-Jun ratio in cells stimulated with H₂O₂ compared to control cells. …”

Contribution of JNK isoforms to TNF-α-induced IL-8 expression. by Shinichi Namba (3350288)

“…<p>(A) Expression of phosphorylated JNK1/2 (p-JNK1/2) and total JNK1/2 (t-JNK1/2) was detected by western blotting in cells treated with TNF-α (50 ng/mL) for 0–120 min (upper panel). …”

Table_1_Distinct Brain Regions in Physiological and Pathological Brain Aging.docx by Jin San Lee (6849692)

“…Background<p>Studying structural brain aging is important to understand age-related pathologies, as well as to identify the early manifestations of the Alzheimer’s disease (AD) continuum. In this study, we investigated the long-term trajectory of physiological and pathological brain aging in a large number of participants ranging from the 50s to over 80 years of age.…”

Ama controls the pool of myoblast number independently of Nrt. by Blandine Moucaud (11844047)

“…<p><b>(A–D)</b> L3 leg discs immunostained for Twi (magenta). …”

Performance w.r.t. Number of Realizations. by Ivan Komarov (120593)

“…<p>Both the strongly connected and the weakly connected systems show a decrease in time per update as the number of realizations is increased. …”

Table 1_Seeds of success: seed biology and germination response of Gazania weed in Australia.xlsx by Muhammad Adnan (678952)

“…Population 1 was more tolerant to salinity than Pop-3 with a 50% reduction in germination occurring at 268 and 252 mM NaCl, respectively. …”

E protein residues critical for neutralization by bnAbs. by Jay Lubow (772012)

“…<p>(Left panel) Bar graphs show the mean IC50 fold change against DENV2 16681 reporter virus particles encoding E protein variants relative to wild type (WT) DENV2 for antibodies <b>(A)</b> F09.S05, <b>(B)</b> F05.S03, <b>(C)</b> J9, <b>(D)</b> F25.S02, and <b>(E)</b> EDE1-C10. …”

Regulation of spine neck resistance maintains local EPSP amplitude during synaptic plasticity. by Allan T. Gulledge (325673)

“…C) Plots of the decrease in spine neck resistance (% of control) required to preserve local EPSP amplitude following a 50% increase in AMPA conductance for spines with different initial spine neck resistances.…”

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells by Damodara Reddy Vaddi (467087)

“…The changes in protein expression were associated with ~50% decrease in hERG potassium conductance. ER retention of hERG 125kDa form by CH was due to defective trafficking and was rescued by exposing cells to hypoxia at low temperatures or treatment with E-4031, a hERG channel blocker. …”

Cytochalasin Delocalizes VASP from the Leading Edge, Changing the F-Actin Network and Cell Shape by Catherine I Lacayo (34086)

“…<div><p>(A) Time-lapse images show that overexpressed EGFP-VASP, which is enriched at the leading edge before addition of 1.0 μM cytochalasin D (time: 1:00, left panel), becomes weaker at the leading edge ∼2 min after cytochalasin treatment (time: 2:50, middle panel). …”

Deconvolution of Kombucha Tea facilitates the creation of fermenting and non-fermenting mixes of KTM. by Rachel N. DuMez-Kornegay (18271479)

“…(C) Oil Red O staining of day 1 adult animals fed an <i>E</i>. <i>coli</i> OP50, KTM-Mix, or KTMs diet, as well as a 5X concentrated version of the KTM diet (mean ± SD, ****, <i>P</i><0.0001, one-way ANOVA). …”

Direct effects of NT-plasma on intracellular ROS production. by Marla J. Steinbeck (496328)

Probiotics regulate Toll-like receptor (TLR) pathway in the lung 24 hours post CLP. by Ludmila Khailova (337471)

“…<p>Reverse transcription and real-time PCR assays were performed to quantify steady-state mRNA levels of TLR-2, TLR-4, MyD88 and NFΚB (p50/p105). (A) TLR-2 and (C) MyD88 were significantly upregulated in the septic group compared to shams (P<0.05) and significantly downregulated in the lungs of LGG and BL treated septic mice compared to untreated septic mice. …”

Photomicrographs depicting typical brain regions of analysis for the prelimbic (PrL), infralimbic (IL) and the orbitofrontal cortex (OFC) divisions of the prefrontal cortex. by Jing Li (10611)

Supplementary Material for: Identification of risk factors associated with metabolic dysfunction-associated steatotic liver disease in psoriatic patients by Küçük K. (20178678)

“…Discussion. We identified parameters which were more prevalent in patients with psoriasis having MASLD, specifically a high BMI, elevated triglycerides levels, decreased HDL levels and an elevate level of C-peptide. …”