Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination by Monica Ghidinelli (4164244)

“…Lm211 can inhibit Nrg1III by limiting protein kinase A (PKA) activation, which is required to initiate myelination. We provide evidence that excessive PKA activation amplifies promyelinating signals downstream of neuregulin, including direct activation of the neuregulin receptor ErbB2 and its effector Grb2-Associated Binder-1 (Gab1), thereby elevating the expression of the key transcription factors Oct6 and early growth response protein 2 (Egr2). …”

Comparative Toxicogenomic Responses to the Flame Retardant mITP in Developing Zebrafish by Derik E. Haggard (3395360)

“…Regardless of <i>ahr2</i> status, mITP exposure resulted in decreased expression of transcripts related to the synthesis of all-<i>trans</i>-retinoic acid and a host of Hox genes. …”

Supplementary Material for: Circulating thrombospondin 1 (THBS1): A a risk factor for Non-Alcoholic Fatty Liver Disease in obese children. by Li M. (3278253)

Is the sky the limit? On the expansion threshold of a species’ range by Jitka Polechová (5400749)

Image_2_Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via... by Junping Bao (10931142)

“…From the specimen analysis of the IDD patients, we found phosphorylated eIF2α (p-eIF2α), ATF4 and Ihh protein levels were positively related while the NP tissue went degenerative. …”

DataSheet_1_A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinom... by Rone A. De Grandis (11017173)

“…Interestingly, we found that N-acetyl-L-cysteine, a ROS scavenger, suppressed the generation of intracellular ROS induced by complex (2), and decreased its cytotoxicity, indicating that ROS-mediated DNA damage leads the DU-145 cells into apoptosis. …”

DataSheet_1_Photorespiration in eelgrass (Zostera marina L.): A photoprotection mechanism for survival in a CO2-limited world.pdf by Billur Celebi-Ergin (14103882)

“…Yet, CO₂ enrichment decreased the light level to initiate NPQ activity and downregulated the biomass specific pigment content by 50% and area specific pigment content by 30%. …”

Supplementary Material for: Cystamine Treatment Fails to Prevent the Development of Pulmonary Hypertension in Chronic Hypoxic Rats by Markvardsen L.K. (10714539)

“…<b><i>Introduction:</i></b> Pulmonary hypertension is characterized by vasoconstriction and remodeling of pulmonary arteries, leading to right ventricular hypertrophy and failure. We have previously found upregulation of transglutaminase 2 (TG2) in the right ventricle of chronic hypoxic rats. …”

Data Sheet 2_TSG-6 promotes healing of critical-sized bone defects in mice.pdf by Oliver Küppers (22742732)

“…To investigate the in vivo relevance, we assessed the effects of locally delivered recombinant TSG-6 (rTSG-6), embedded in a collagen gel, on bone regeneration in a 1.5 mm critical-sized femoral defect model in male C57BL/6J mice. …”

Loss of the Synaptic Vesicle Protein SV2B Results in Reduced Neurotransmission and Altered Synaptic Vesicle Protein Expression in the Retina by Catherine W. Morgans (267419)

“…Of the three isoforms expressed in mammals, SV2B is the most divergent. Here we report studies of SV2B location and function in the retina. …”

Assessing resolution and calibration of confidence. by Medha Shekhar (19502698)

“…We found that temperature scaling indeed reduced overconfidence in all networks (4-layer CNN: confidence decreased from 0.968 to 0.737; VGG-10: confidence decreased from 0.964 to 0.783, ResNet-50: confidence decreased from 0.982 to 0.748). …”

Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast by Yan Ma (88810)

“…<div><p>In the fission yeast, two Tor isoforms, Tor1 and Tor2, oppositely regulate gene expression of amino acid permeases. …”

Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria by Al-Sadeq, Duaa W.

“…In this study, we present the clinical and biochemical characterization of two novel CBS missense mutations that do not respond to pyridoxine treatment, namely c.689T > A (L230Q) and 215A > T (K72I), identified in a Chinese patient. …”
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Homolog pairing and sister chromatid cohesion in interphase remain unaffected genome-wide after knockdown of Rad21. by T. Niroshini Senaratne (3067776)

“…A simple separation of sister chromatids would be expected to cause a decrease in the percentage of nuclei with a single FISH signal, or an increase in the area of FISH signals; we observed neither (see main text for details).…”

Inhibition of Cav3 binding affects Ca²⁺ homeostasis, cytoskeletal-membrane interactions and MSC activity. by Haixia Huang (452278)

“…(B) We loaded myotubes with Fluo4-AM and monitored Ca²⁺ levels during application of test substances. …”

Data Sheet 2_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.pdf by Miguel Ângelo-Dias (20936444)

“…</p>Methods<p>A total of 50 pregnant and 30 age-matched non-pregnant women were recruited in a prospective cohort study. …”

Table_1_Deficiency of Human Adenosine Deaminase Type 2 – A Diagnostic Conundrum for the Hematologist.docx by Rakesh Kumar Pilania (9774821)

“…In this review, we describe the evolving clinical phenotypes of DADA2 with a special focus on haematological and immunological manifestations.…”

Image2_Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms.TIF by Talita Glaser (302466)

Image_2_Bidirectional Mendelian randomization study of insulin-related traits and risk of ovarian cancer.png by Xinghao Wang (802907)

“…</p>Results<p>Among all insulin related indicators (fasting insulin level, insulin secretion rate, peak insulin response), the insulin secretion rate was selected to have a causal relationship with the occurrence of ovarian cancer (IVW, P < 0.05), that is, the risk of ovarian cancer increased with the decrease of insulin secretion rate. At the same time, we tested the heterogeneity and polymorphism of this indicator, and the results were non-existent, which ensured the accuracy of the analysis results. …”

Table_2_Lipid-lowering medications and risk of malignant melanoma: a Mendelian randomization study.xlsx by BoWen Yang (18861130)

“…</p>Methods<p>Genetic variations within an LDL-related drug target gene (LDL-cholesterol from a genome-wide association study) served as proxies for exposure to lipid-lowering drugs. We conducted a two-sample Mendelian randomization analysis using inverse variance weighting (IVW), MR-Egger, and weighted median approaches. …”