Search alternatives:
point decrease » point increase (Expand Search)
ng decrease » nn decrease (Expand Search), _ decrease (Expand Search), we decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
5 point » _ point (Expand Search)
point decrease » point increase (Expand Search)
ng decrease » nn decrease (Expand Search), _ decrease (Expand Search), we decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
5 point » _ point (Expand Search)
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8961
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8962
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8963
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8964
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8965
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8966
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8967
Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip...
Published 2021“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI<sub>50</sub> of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”
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8968
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8969
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8970
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8971
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8972
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8973
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8974
Kinetics of PI(3,4,5)P3 hydrolysis by PTEN at different concentrations of YFP-PHGrp1.
Published 2018“…<p>(A) The membrane composition is 0.2% PI(3,4,5)P3 + 5% DOPS + 0.2% PI(4,5)P2 + 94.4% DOPC + 0.2% TR-DHPE and the bulk concentration of YFP-PHGrp1 is 100 nM (square), 150 nM (circle), 300 nM (triangle), and 600 nM (down-pointing triangle), respectively. …”
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8975
<i>osm-5</i> acts in AWB to regulate neuronal responses of AWB to IAA, 2-nonanone, and the mixture.
Published 2022“…<b>(B—D)</b> Exposure to IAA increases GCaMP signal of AWB (ON response) and removal of IAA decreases it (OFF response). The <i>osm-5(p813)</i> mutation disrupts both the ON and OFF responses and expressing <i>osm-5</i> in AWB rescues the defects. …”
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8976
<i>Klf5</i> overexpression in intestinal epithelia increases STAT3 phosphorylation <i>in vivo</i>.
Published 2013“…(<b>C</b>) Western blot of colonic epithelial scrapings from control (Cn) and <i>Villin-Klf5</i> (Vl) mice at the indicated time points following DSS treatment revealed increased phospho-STAT3 and phospho-JAK2 in <i>Villin-Klf5</i> mice at day 7, while phospho-STAT3 was decreased in <i>Villin-Klf5</i> mice at day 0 and unchanged at day 3. …”
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8977
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8978
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8979
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8980