Showing 8,961 - 8,980 results of 34,719 for search '(( 50 ((ng decrease) OR (((a decrease) OR (mean decrease)))) ) OR ( 5 point decrease ))', query time: 0.68s Refine Results
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    Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

    Published 2021
    “…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI<sub>50</sub> of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”
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    Kinetics of PI(3,4,5)P3 hydrolysis by PTEN at different concentrations of YFP-PHGrp1. by Chun Liu (47227)

    Published 2018
    “…<p>(A) The membrane composition is 0.2% PI(3,4,5)P3 + 5% DOPS + 0.2% PI(4,5)P2 + 94.4% DOPC + 0.2% TR-DHPE and the bulk concentration of YFP-PHGrp1 is 100 nM (square), 150 nM (circle), 300 nM (triangle), and 600 nM (down-pointing triangle), respectively. …”
  15. 8975

    <i>osm-5</i> acts in AWB to regulate neuronal responses of AWB to IAA, 2-nonanone, and the mixture. by Wenxing Yang (1491607)

    Published 2022
    “…<b>(B—D)</b> Exposure to IAA increases GCaMP signal of AWB (ON response) and removal of IAA decreases it (OFF response). The <i>osm-5(p813)</i> mutation disrupts both the ON and OFF responses and expressing <i>osm-5</i> in AWB rescues the defects. …”
  16. 8976

    <i>Klf5</i> overexpression in intestinal epithelia increases STAT3 phosphorylation <i>in vivo</i>. by Marie-Pier Tetreault (320873)

    Published 2013
    “…(<b>C</b>) Western blot of colonic epithelial scrapings from control (Cn) and <i>Villin-Klf5</i> (Vl) mice at the indicated time points following DSS treatment revealed increased phospho-STAT3 and phospho-JAK2 in <i>Villin-Klf5</i> mice at day 7, while phospho-STAT3 was decreased in <i>Villin-Klf5</i> mice at day 0 and unchanged at day 3. …”
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