Image_2_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Data_Sheet_1_Finger-specific effects of age on tapping speed and motor fatigability.docx by Caroline Heimhofer (19735888)

“…Finger tapping at maximal speed results in a rapid decrease in movement speed, which is a measure of motor fatigability.…”

Supplementar material of the manuscript  The Effects of Lipoic Acid on Yolk Nutrient Utilization, Energy Metabolism, and Redox Balance over Time in <em>Artemia</em> sp.  by Juan Rafael Buitrago Ramírez (6244172)

“…ETS activity was positively regulated by the addition of LA, with the most significant effects at concentrations of 5.0 and 10.0 µM at 12 and 24 h. For ETS activity, treatments with LA presented the highest values at 24 h, a period when ROS production decreased significantly, for the treatment with 10.0 µM. …”

LRG1 modifies the effects of TGFβ on myeloid and hematopoietic progenitor cell growth. by Lawrence J. Druhan (376410)

DELTA-1/NOTCH signaling in the caudal spinal cord of chick embryos. by Barbara Hämmerle (36261)

“…<p>A–A′. Confocal projection over 50 µm from a dorsal aspect of the prospective spinal cord at the level of the 12^th and 13^th somites counted from rostral of a HH13 chick embryo that was electroporated with NICD at stage HH10 when that region was part of the PNTZ. …”

Test of the most likely period associated with orang-utan population decline. by Reeta Sharma (117636)

“…<p>Natural logarithms of the Bayes Factors (BF) have been computed to determine during which of the important phases the populations started to decrease. a) The BF values of parameter <i>T</i> (time since the beginning of the population collapse) for all orang-utan populations were computed for each 500 year time steps and are plotted for last 50,000 years. …”

Short-term time-restricted feeding during the resting phase is sufficient to induce leptin resistance that contributes to development of obesity and metabolic disorders in mice by Katsutaka Oishi (278169)

Methods for Applying Accurate Digital PCR Analysis on Low Copy DNA Samples by Alexandra S. Whale (385335)

“…Furthermore, we also demonstrate that the pre-amplification step can introduce measurement bias that is not consistent between experiments for a sample or assay and so could not be compensated for during the analysis of this data set. …”

Reduced thermal hypersensitivity in S1P₁^−/−mice. by Norbert Mair (113808)

Supporting information data. by Miriam Serrano Soliva (19485617)

The role of AGEs in high glucose-induced voltage-gated K⁺ (K_v) channels dysfunction in vascular smooth muscle cells (VSMCs). by Wen Su (332346)

“…<p>A: Overproduction of AGEs in high glucose was blunted by treatment with aminoguanidine (AG). …”

Knockdown of <i>CPSF6</i> leads to global shifts in PAS usage as well as major transcript and protein abundance changes. by Christoph Schmal (395936)

“…(<b>G</b>) Representative examples that show a decrease (<i>SHISA2</i>, top) or increase (<i>HIPK1</i>, bottom) of transcript abundance upon <i>CPSF6</i> knockdown. …”

Microtubule inhibitors cause cell cycle arrest and induce RKIP expression. by Saad Yousuf (541082)

“…Analysis for apoptosis was performed using a FACSCalibur flow cytometer (Data represents the mean ± S.D., of 2 independent experiments performed in duplicate). …”

Nef Targets ABCA1-Dependent Cholesterol Efflux by Zahedi Mujawar (379543)

Possible effects of estrogens deprivation and aging on inflammation and endothelial damage at menopause. by Nicté Figueroa-Vega (741283)

“…<p>When estrogens decline and during old age, important changes occur in the endothelium: first, estrogen decrease, leads a low NO bioavailability inducing destabilization of endothelial cells, favoring up-regulation of adhesion molecules. …”

[Ca²⁺] dynamics comparison between WT network and blocking an individual NFA-sensitive channel. by Jesús Espinal-Enríquez (622164)

“…Concentration units are arbitrary, they comply with the above restrictions and are set for comparative purposes, time is measured by simulation steps and frequency refers to the fraction of a cycle covered by a simulation step, i.e cycles per simulation step. …”

Representative results of integrate-and-fire simulations for different learning rules. by Kendra S. Burbank (180062)

“…The simulations in <b>b–d</b> were classified as having “extreme weights” meaning that >50% of the weights were either at 0 or at the weight boundaries (±50). …”

Organ level model. by Shayoni Ray (179927)

“…<p>An organ-level simulation containing three ideally localized clefts is shown at (a) 0 MCS and (b) 1500 MCS (Scale = 50 µm). The results were quantified with (c) cleft depth and (d) spanning angle. …”

Economic evaluation of an active search system to monitor the outcomes of health-related claims by Nayara Luiza Pereira Rodrigues (8303202)

“…Results: The advisory service promoted a decrease of 40% (p=0.01) in lawsuits. There was a 31% reduction in court costs (p=0.003), with medicines accounting for 33% of this amount. …”