Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections by Zhen-Meng Zhang (20874497)

“…This study synthesized benzothiazole-conjugated hydroxamic acid derivatives as dual-acting biofilm inhibitors, and compound <b>JH21</b> was identified as the hit compound with potent submicromolar biofilm inhibitory activity (IC₅₀ = 0.4 μM). Further mechanistic studies demonstrated not only that the production of virulence was decreased through mainly inhibiting QS system but also that <b>JH21</b> competed for iron with the high-affinity siderophore pyoverdine, inducing iron deficiency and inhibiting biofilm. …”

Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse by Charles E. Hay (5470526)

“…These results suggest that AAV-delivered scFv could be a promising therapy to treat methamphetamine abuse.…”

The food consumption quantity. by Bingtao Su (4740009)

Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension by Tetsuo Asaki (1366140)

Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension by Tetsuo Asaki (1366140)

Nampt overexpression attenuated cell senescence in MSCs obtained from the old group. by Cao Ma (3710134)

Determinants for Substrate Recognition in the Glycyl Radical Enzyme Benzylsuccinate Synthase Revealed by Targeted Mutagenesis by Iryna Salii (10219821)

Data from: Developing a growing degree day model to guide integrated pest management of <i>Eucosma giganteana, </i>a pest of a novel perennial oilseed crop by HAZEL SCRIBNER (20664341)

“…In each transect, one of the traps was baited with a control of 50 µl of acetone inside a 3-mL dropping bottle, the rest were baited with 50 µl diluted (<i>E</i>)-8-dodecenyl acetate at three concentrations. …”

Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents by WooChan Kim (10690503)

“…Moreover, treatment with compound <b>23h</b> for 5 weeks significantly decreased serum levels of HBV DNA levels (3.35 log reduction) in a human liver-chimeric uPA/SCID mouse model, and these effects were significantly increased when <b>23h</b> was combined with tenofovir, a nucleotide analogue inhibitor of reverse transcriptase used for the treatment of HBV infection.…”

Isoindolin-1-ones Fused to Barbiturates: From Design and Molecular Docking to Synthesis and Urease Inhibitory Evaluation by Houman Kazemzadeh (12742141)

“…In vitro urease inhibitory results indicated that all the compounds had higher inhibitory activity than the standard inhibitor, thiourea, and compound <b>5b</b> proved to be the most potent inhibitor (IC₅₀ = 0.82 ± 0.03 μM). A molecular docking study was performed to understand the interaction between compounds <b>5a–n</b> and Jack bean urease enzyme. …”

GFP+ NPC Implant Apoptosis. Implants were sectioned and immunostained for the early effector caspase, cleaved caspase-3 (red, GFP = green, DAPI = blue) and area of fluorescence rel... by Cicely Williams (291856)

“…<p>This initially higher rate of apoptosis significantly decreased by day 5 (0.036±0.050, p = 0.0063) to a rate comparable to that of the NPC∶BEC implants. …”

<i>In silico</i> screening identifies doxazosin as a novel agonist for EphA2 receptor. by Aaron Petty (143170)

“…Note decreasing amount of EphA2 following ephrin-A1 and doxazosin treatment. …”

Zwitterion-Functionalized Cuprous Oxide Nanoparticles for Highly Specific and Enzymeless Electrochemical Creatinine Biosensing in Human Serum by R. K. Rakesh Kumar (14241205)

“…A linear response to creatinine concentration from 10 to 200 μM (<i>R</i>² = 0.9876 and LOD = 5.0 μM) was observed, which covers the entire range of physiological creatinine in human serum. …”

CRISPR-Cas9-mediated mutation analysis of T₀ Stmc7 mutants. by Bikram Poudel (15989201)

Hyperparameter of model. by Yeongha Kim (12174924)

Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening by Shoya Yamada (1639105)

Characteristics of included studies. by Zahra Ali Padhani (8959490)

S1 File - by Ingmar Lundquist (46422)

“…Culturing at high glucose increased both nNOS and iNOS activities inducing a marked decrease in GSIS in a following short-term incubation at high glucose. …”

First fill recorder. by Zhidong Yu (15397883)

Proposed model of apoptotic-like programmed cell death (AL-PCD) in plants. by Bikram Poudel (15989201)