Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments by Stefania Ferro (76724)

“…The inhibition of tyrosinase (Ty, EC 1.14.18.1) represents an efficient strategy of decreasing melanogenesis and skin hyperpigmentation. …”

Parameter values for best fit of simulated anesthesia and cholinergic reversal. by Bolaji P. Eniwaye (12915339)

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies by Brianna D. Mackie (9212677)

“…Its cell-permeable analogue <b>DC432</b> (IC₅₀ of 54 ± 4 nM) decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells. …”

Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes by Wipawee Wongchana (5367968)

“…A similar impact on IL-10 production was observed when Notch signaling was inhibited with a gamma-secretase inhibitor (GSI). …”

Effects of GSI treatment on MAPK, PI3K/AKT and NF-κB pathway activation in LPS/IC-activated macrophages. by Wipawee Wongchana (5367968)

“…The arrows indicate cells with decreased or no p50 nuclear translocation (green). …”

Liquid cultures in RPMI-1640. by Nicholas C. Schena (16541975)

CgA silencing, processing enzyme inhibition and functional analysis of CgA peptides in SI-NEN cell lines. by Francesco Giovinazzo (487256)

“…Inhibition of the CgA processing enzyme prohormone convertase using Decanoyl-Arg-Val-Lys-Arg-CMK also decreased proliferation of H-STS cells (25 µM [<i>data not shown</i>] and 50 µM, <b>4D</b>, *<i>p</i><0.05). …”

Phase Behavior and Self-Assembly of Semiflexible Polymers in Poor-Solvent Solutions by Tobia Arcangeli (19540447)

Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo by Huiyan Hu (9376570)

“…Surprisingly, its liposome-entrapped complexes 3alip, 3blip, and 3clip on B16 cells showed strong cytotoxicity (IC₅₀ = 13.6 ± 2.8, 9.6 ± 1.1, and 18.9 ± 2.1 μM). …”

Estimated numbers of people aged 65+ years living with dementia under various scenarios and difference to ageing-only scenario. by Binod Nepal (625271)

Fig 1 - by Gilda Cennamo (448296)

“…</b> Left eye of a patient (50 years-old female) with pitituary adenoma before surgery reveals a reduction of vessel density in SCP (A1), DCP (B1), RPC (C1) and an increase of FAZ area (D1) respect to healthy subject. …”

B6 <i>mA3</i> is a saturable innate restriction factor <i>in vivo</i>. by Diana S. Smith (176104)

Examples of dynamic response of g_s and A_max after detachment of the leaf (A: calculation of the dynamic parameters in a leaf with 0% visible injury, B: time c... by Yasutomo Hoshika (319347)

HCV RNA was quantified by RT-QPCR after infection in stable cell lines. by Sobia Manzoor (11372369)

Cashtags become substantially more popular after Musk purchased X. by Daniel Hickey (20714822)

Minimal dataset. by Herindita Puspitaningtyas (11618232)

“…During 2008–2019, trends of colon cancer in age <50 increased by 8.15% annually while rectal cancer displayed a 9.71% increase annually prior to 2017, followed by a 17.23% decrease until 2019.…”

Follow up analysis (sample 69). by Martin M. J. Kirschner (727302)

i(A)CG strategies in the final population. by Anton M. Unakafov (5706560)

<i>Kif3a</i> controls renal branching morphogenesis in a GLI3R-dependent manner. by Lijun Chi (196000)

“…(T) Quantitation of NCAM-positive structures in N, O and P reveals a significant decrease in <i>Kif3a^−/−UB</i> mice compared to WT and <i>Kif3a^−/−UB</i>;<i>Gli3^Δ699/+</i> mice. (*, P<0.05, **, P<0.01, *** P<0.001). …”

The effects of glucose on <i>K</i>. <i>pneumoniae</i> STU1. by Yu-Tze Horng (2043019)