The core model with an additional intracellular feedback is superior and gene expression upon downregulation of IRF family members. by Katharina Robichon (8445099)

“…(<b>H</b>) Gene expression upon decreased <i>IRF8</i> expression. Huh7.5 cells were incubated with 50 nM siRNA directed against <i>IRF8</i> (red), against <i>IRF8</i> and <i>IRF2</i> (lilac) or non-targeting control (blue) for 24 hours, and then treated with 500 U/ml IFNα. …”

Image_1_PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemi... by Masaya Suematsu (12006506)

“…We previously reported that piggyBac (PB) transposon-mediated CD19 CAR-T cells exhibit a memory-rich phenotype that is characterized by the high proportion of CD45RA⁺/C-C chemokine receptor type 7 (CCR7)⁺ T-cell fraction. …”

Data_Sheet_1_Increased fruit intake is associated with reduced risk of depression: evidence from cross-sectional and Mendelian randomization analyses.docx by Zhaoqi Yan (11322876)

“…Fruit intake was also associated with a decreased risk of neuroticism traits related to depression, including feeling lonely (OR = 0.82, 95% CI = 0.74–0.90; p = 2.91E-05), feeling miserable (OR = 0.79, 95% CI = 0.72–0.87; p = 2.35E-06), feeling fed-up (OR = 0.75, 95% CI = 0.68–0.83; p = 2.78E-08), irritable mood (OR = 0.89, 95% CI = 0.79–0.99; p = 0.03), and neuroticism (OR = 0.85, 95% CI = 0.76–0.96; p = 9.94E-03). …”

Image_6_PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemi... by Masaya Suematsu (12006506)

“…We previously reported that piggyBac (PB) transposon-mediated CD19 CAR-T cells exhibit a memory-rich phenotype that is characterized by the high proportion of CD45RA⁺/C-C chemokine receptor type 7 (CCR7)⁺ T-cell fraction. …”

Image_3_PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemi... by Masaya Suematsu (12006506)

“…We previously reported that piggyBac (PB) transposon-mediated CD19 CAR-T cells exhibit a memory-rich phenotype that is characterized by the high proportion of CD45RA⁺/C-C chemokine receptor type 7 (CCR7)⁺ T-cell fraction. …”

Data_Sheet_1_BCR-ABL1 Doubling-Times and Halving-Times May Predict CML Response to Tyrosine Kinase Inhibitors.PDF by Maria Stella Pennisi (6371525)

“…Thus, we retrospectively examined BCR-ABL1 evolution in 305 chronic-phase CML patients receiving imatinib mesylate (IM) as a first line treatment. Patients were subdivided in two groups: those with a confirmed rise in BCR-ABL1 transcripts without MR^3.0 loss and those failing IM. …”

Gender-Specific Effects of Genetic Variants within Th1 and Th17 Cell-Mediated Immune Response Genes on the Risk of Developing Rheumatoid Arthritis by Rafael Cáliz (452151)

“…Carriers of <i>Dectin-2</i>_rs4264222T allele had an increased risk of RA (OR = 1.47, 95%CI 1.10–1.96) whereas patients harboring the <i>DC-SIGN</i>_rs4804803G, <i>MCP-1</i>_rs1024611G, <i>MCP-1</i>_rs13900T and <i>MCP-1</i>_rs4586C alleles had a decreased risk of developing the disease (OR = 0.66, 95%CI 0.49–0.88; OR = 0.66, 95%CI 0.50–0.89; OR = 0.73, 95%CI 0.55–0.97 and OR = 0.68, 95%CI 0.51–0.91). …”

Expression of RIO kinases is associated with EGFR and Akt activity in GBM cells. by Renee D. Read (268044)

“…(G) Neurosphere cultures treated for 24 hours with DMSO or indicated inhibitors. P110 inhibitors: 50 µM LY294002, 1 µM BEZ-235, 2 µM GDC-0941 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003253#pgen.1003253-Raynaud1" target="_blank">[71]</a>, 2 µM PI-103 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003253#pgen.1003253-Raynaud1" target="_blank">[71]</a>. …”

Plasma MicroRNAs as Potential Noninvasive Biomarkers for In-Stent Restenosis by Meijiao He (666387)

“…</p><p>Methods</p><p>This retrospective, observational single-centre study was conducted at the cardiovascular department of a tertiary hospital centre in the north of China. …”

DataSheet_1_Transcriptome analysis reveals that auxin promotes strigolactone-induced adventitious root growth in the hypocotyl of melon seedlings.pdf by Jingrui Li (1546318)

“…Compared to that in the control, the ABA content decreased by 10.30%–11.83% in the GR24 treatment group and decreased by 18.78%-24.00% in the GR24+IAA treatment group at 6–10 days.…”

RNA-seq transcriptomics analysis in human tissue culture cells reveals changes in the expression levels of over 100 nucleolar mRNAs after PAX9 knockdown. by Katherine I. Farley-Barnes (9258036)

“…Of these, 812 mRNAs had a decreased fold change (≤ -2) and 184 of those mRNAs code for proteins designated as nucleolar in at least one of three databases [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008967#pgen.1008967.ref050" target="_blank">50</a>–<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008967#pgen.1008967.ref052" target="_blank">52</a>]. …”

Enhanced drug resistance suppression by serum-stable micelles from multi-arm amphiphilic block copolymers and tocopheryl polyethylene glycol 1000 succinate by Lei He (143930)

“…<p><b>Aim:</b> To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy.…”

Data_Sheet_1_MicroRNA29B induces fetal hemoglobin via inhibition of the HBG repressor protein MYB in vitro and in humanized sickle cell mice.docx by Qingqing Gu (338902)

“…</p>Materials and methods<p>Human KU812 were cultured and normal CD34 cells (n = 3) were differentiated using a two-phase erythropoiesis culturing system and transfected with MIR29B (50 and 100 nM) mimic or Scrambled (Scr) control in vitro. …”

Early initiation of breastfeeding and severe illness in the early newborn period: An observational study in rural Bangladesh by Shahreen Raihana (828393)

“…id=362279" target="_blank">ACTRN12612000588897</a>.</p></div>…”

Evidence for rapid downward fecundity selection in an ectoparasite (Philornis downsi) with earlier host mortality in Darwin’s finches by Sonia Kleindorfer (95761)

“…In other years and locations, traps were placed ad hoc every 50 m within 100 m x 200 m plots spanning a 2 km transect within study sites. …”

Cif redirects CFTR from recycling endosomes to the lysosomal, degradative pathway. by Jennifer M. Bomberger (226715)

“…Purified OMV from <i>P. aeruginosa</i> (PA14), a recently isolated laboratory strain, and clinical isolates (CF and pseudomonal pneumonia) applied to airway epithelial cells for 90 minutes decreased cell lysate and apical membrane abundance of CFTR. …”

Data_Sheet_2_Probiotics and Synbiotics Addition to Bama Mini-Pigs' Diet Improve Carcass Traits and Meat Quality by Altering Plasma Metabolites and Related Gene Expression of Offspr... by Qian Zhu (191342)

“…<p>This study evaluated the effects of maternal probiotics and synbiotics addition on several traits and parameters in offspring. A total of 64 Bama mini pigs were randomly allocated into the control (basal diet), antibiotic (50 g/t virginiamycin), probiotics (200 mL/day probiotics), or synbiotics (500 g/t xylo-oligosaccharides and 200 mL/day probiotics) group and fed with experimental diets during pregnancy and lactation. …”

Data_Sheet_1_Probiotics and Synbiotics Addition to Bama Mini-Pigs' Diet Improve Carcass Traits and Meat Quality by Altering Plasma Metabolites and Related Gene Expression of Offspr... by Qian Zhu (191342)

“…<p>This study evaluated the effects of maternal probiotics and synbiotics addition on several traits and parameters in offspring. A total of 64 Bama mini pigs were randomly allocated into the control (basal diet), antibiotic (50 g/t virginiamycin), probiotics (200 mL/day probiotics), or synbiotics (500 g/t xylo-oligosaccharides and 200 mL/day probiotics) group and fed with experimental diets during pregnancy and lactation. …”

Image_2_An Analysis Based on Japonica Rice Root Characteristics and Crop Growth Under the Interaction of Irrigation and Nitrogen Methods.png by Zhuoqian Wang (9012881)

“…From full heading to maturity stages, N2 could promote root growth, LAD, and CGR under AWD to a greater extent than those under the other treatments. …”

6MWT results. by Imane Salmam (21485704)

“…Notably, all studies assessing the 6-minute walk test (6MWT) reported reduced distances, consistently falling below the 50^th percentile of normative values. …”