Combinatorial Synthesis and in Vitro Evaluation of a Biaryl Hydroxyketone Library as Antivirulence Agents against MRSA by Guanping Yu (1345770)

“…An acylation bond-forming process afforded resorcinols (<b>1</b>) and aryloxy acetonitriles (<b>2</b>) as synthons. A Lewis-acid-activated Friedel–Crafts’ acylation step involving a nitrile functionality of <b>2</b> by ZnCl₂, followed by nucleophilic attack by <b>1</b> was executed to obtain biaryl hydroxyketones in excellent yields. …”

Effect of mutations on neutralization by antibodies elicited by 2x BNT162b2 vaccination, Delta breakthrough after 2x mRNA vaccination, or primary Delta infection. by Allison J. Greaney (11046384)

“…<p><b>(A)</b> Neutralization titer 50% (NT50) of spike-pseudotyped lentiviral particles by sera or plasmas from individuals with various exposure histories. …”

PDIM production and export is required for induction of the macrophage type I IFN response. by Amy K. Barczak (525258)

“…<i>05</i>, and for the comparison of Rv with <i>lppX</i>, <i>pks15</i>, <i>Rv2949c</i>, and <i>mutT4</i> were non-significant. (C) A <i>drrC</i> transposon mutant was complemented with tetracycline-inducible, chromosomally-integrated <i>drrC</i>; <i>drrC</i> expression was induced with 50ng/ml or 100ng/ml aTc. …”

Adverse effect of ND251 aggregates on neurite outgrowth. by Huei-Ying Li (210957)

“…Cells expressing ND251S5A had a further decrease in the percentage of neurite-bearing cells in comparison with ND251. …”

Efficacy of dexamethasone and ACTH in drug resistant pediatric epilepsy. by Nicola Marchi (4967)

“…(<b>B</b>) Mosaic plot showing the correlation between etiology of epilepsy and likelihood of a response ≥50%. Note that etiology did not always predict response. …”

Different simulation protocols of increased firing and depressed activity. by Isabelle Ayumi Spühler (444465)

“…After 4 sec, 50% of release sites increase or decrease their release for a short time window to simulate phasic firing of the dopaminergic neurons. …”

Sensitivity of biomass and cumulative harvest to magnitude of climate impacts under alternative management strategies. by Jameal F. Samhouri (10136090)

“…<p>Outcomes of implementing fixed versus annual climate adaptive harvest management strategies on mean population biomass and cumulative harvest over 50-year simulations in a population subject to a gradual decrease or increase in carrying capacity <b>(a, d)</b>, productivity <b>(b, e)</b>, and both carrying capacity and productivity <b>(c, f)</b>. …”

Percent differences between the fixed and climate adaptive harvest management strategies in mean biomass and cumulative harvest at different time intervals in the simulations. by Jameal F. Samhouri (10136090)

“…<p>Percent differences in mean biomass and cumulative harvest between the fixed and climate adaptive harvest management strategies for 16-year time intervals throughout the 50-year simulations in populations subject to a gradual decrease in (a) carrying capacity, (c) productivity, (e) both carrying capacity and productivity, or a gradual increase in (b) carrying capacity, (d) productivity, (f) both carrying capacity and productivity. …”

Image_6_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_4_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Neuronal complexity was greatly reduced by neuronal GALC depletion. by Conlan Kreher (13001753)

“…<p>(<b>A, B</b>) Double transgenic mice of 1-year-old <i>Syn1Cre; Galc flox/−;</i> Thy1.1-YFP shows that a decrease in the density of YFP neurons/axons in the brainstem and cerebellum, compared to control (<i>Galc +/−;</i> Thy1.1-YFP). …”

Image_1_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_5_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_2_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_3_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

AZ2.0 Scripts & Code by Binay Panda (768771)

“…The updated genome assembly (v2.0) yielded 3- and 3.5-fold increase in N50 and N75, respectively; 2.6-fold decrease in the total number of scaffolds; 1.25-fold increase in the number of valid transcriptome alignments; 13.4-fold less mis-assembly and 1.85-fold increase in the percentage repeat, over the earlier assembly (v1.0). …”

Altered Heart Rates Precede Death. by David S. Auerbach (470466)

“…<p>A. DS mice exhibit significant QT prolongation (50 - 90%). …”

Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia-1 by John K Neubert (30743)

“…Animals pretreated with vehicle (0.25% Tween-80, PBS 50 μl, N = 10) had a significant decrease in their heat withdrawal latency (P < 0.05, 1 way RM-ANOVA) following induction of inflammation.…”

Behavioral stress fails to delay surgical castration-induced involution and apoptosis in mice prostates. by Sazzad Hassan (454373)

“…<p><b>A)</b> Castration-induced prostate involution. …”

Watermelon cultivation in the semi-arid irrigated with different heights of treated domestic sewage by Vinicius Couto Salgado (5668235)

“…We observed an increase in the cation exchange capacity and a decrease of the soil pH in all the treatments. …”