Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploring the mechanism of SNAPC2 in liver cancer. by Benzun Wei (21485639)

Consort diagram. by Laura Ormesher (17131361)

Impact of radiation on bone marrow is dose dependent. by Tien T. Tang (3615287)

Genome-wide regulation of electro-acupuncture on the neural <i>Stat</i>5-loss-induced obese mice - Fig 4 by Shu-Ping Fu (549948)

“…<p>EA treatment altered the abnormally expressed genes both in the hypothalamus (A-E) and Epi-WAT of <i>Stat</i>5NKO mice (F-I). (A) Overlapping area represents upregulated gene number (310) in the <i>Stat</i>5NKO group (<i>vs</i>. the <i>Stat</i>5fl/fl group) but decreased in the EA group; (B) The heatmap was created using the FPKM values of the 310 overlapping genes in 5A; (C) Pathway analysis of the 310 overlapping genes in 5A. …”

Apoptosis inhibitor abolished and restored rTsSPc-disrupted Caco-2 monolayer barrier integrity. by Qi Qi Lu (17721401)

Influence of Thiolate Ligands on Reductive N−O Bond Activation. Probing the O₂⁻ Binding Site of a Biomimetic Superoxide Reductase Analogue and Examining the P... by Gloria Villar-Acevedo (2232583)

“…Like NO-bound <i>trans</i>-cysteinate-ligated SOR (SOR-NO), the rhombic <i>S</i> = 3/2 EPR signal of NO-bound <i>cis</i>-thiolate-ligated [Fe(S^Me₂N₄(tren)(NO)]⁺ (<b>2</b>; <i>g</i> = 4.44, 3.54, 1.97), the isotopically sensitive ν_NO(ν_¹⁵NO) stretching frequency (1685(1640) cm⁻¹), and the 0.05 Å decrease in Fe−S bond length are shown to be consistent with <i>the oxidative addition of NO to Fe(II)</i> to afford an Fe(III)−NO⁻ {FeNO}⁷ species containing high-spin (<i>S</i> = 5/2) Fe(III) antiferromagnetically coupled to NO⁻ (<i>S</i> = 1). …”

Influence of Thiolate Ligands on Reductive N−O Bond Activation. Probing the O₂⁻ Binding Site of a Biomimetic Superoxide Reductase Analogue and Examining the P... by Gloria Villar-Acevedo (2232583)

“…Like NO-bound <i>trans</i>-cysteinate-ligated SOR (SOR-NO), the rhombic <i>S</i> = 3/2 EPR signal of NO-bound <i>cis</i>-thiolate-ligated [Fe(S^Me₂N₄(tren)(NO)]⁺ (<b>2</b>; <i>g</i> = 4.44, 3.54, 1.97), the isotopically sensitive ν_NO(ν_¹⁵NO) stretching frequency (1685(1640) cm⁻¹), and the 0.05 Å decrease in Fe−S bond length are shown to be consistent with <i>the oxidative addition of NO to Fe(II)</i> to afford an Fe(III)−NO⁻ {FeNO}⁷ species containing high-spin (<i>S</i> = 5/2) Fe(III) antiferromagnetically coupled to NO⁻ (<i>S</i> = 1). …”

Antibiotic Resistome Changes Associated with Different Types of Corrosion Inhibitors When Chlorine is Used as a Disinfectant by Lee K. Kimbell (21520910)

Predicted metabolite levels for each reaction intermediate shown in Figure 7 under conditions in which the NAD+:NADH ratio is 31 (Bennett et al. [26]), or decreased by either 0.1-f... by William R. Cannon (608586)

Heat hyperalgesia induced by CFA peripheral injection was significantly inhibited by intrathecal administration of roscovitine, K252a and TrkB-IgG. by Hong-Hai Zhang (304558)

“…PWL to thermal stimuli significantly increased following intrathecal injection of TrkB-IgG 0.5 h prior to CFA injection compared to the PWL of the control group, **<i>P</i><0.01, (n = 6, per group) (D).…”

Kaplan-Meier survival curve. by Benzun Wei (21485639)

Identification of DEGs. by Benzun Wei (21485639)

DataSheet1_Processing of RNA Containing 8-Oxo-7,8-Dihydroguanosine (8-oxoG) by the Exoribonuclease Xrn-1.PDF by Cheyenne N. Phillips (11702090)

“…The observed fragment(s) were characterized via PAGE and MALDI-TOF to confirm that the oligonucleotide fragment(s) contained a 5′-phosphorylated 8-oxoG. Furthermore, the yields for this stalling varied from app. 5–30% with 8-oxoG located at different positions and in different sequences. …”