First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Downregulation of DOM decreases the abundance of PER and TIM. by Zhenxing Liu (399809)

“…Downregulation of DOM decreased PER levels at CT1-5 and CT17-21. (Scale bar: 50 um.) …”

Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

Linear decrease of delta power (1.1–5.0 Hz) across the first three sleep cycles in the cortical, hippocampal and scalp recordings. by Fabio Moroni (34208)

The probability of having a tie decreases as a function of distance. by Jukka-Pekka Onnela (353658)

“…Note that if geography played no role, we would expect to be independent of distance , resulting in a horizontal line in this plot. …”

Incubation of <i>T</i>. <i>brucei</i> with Pol I transcription inhibitors results in a dramatic decrease in VEX1 foci. by Louise E. Kerry (3815164)

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Predicted probabilities of having received a mammogram within the past 2 years: model with an interaction term between obesity and disability score. by Clémence Bussière (617221)

Supramolecular DNA Photonic Hydrogels for On-Demand Control of Coloration with High Spatial and Temporal Resolution by Yixiao Dong (2174902)

“…We solve this problem by creating a DNA hydrogel system that shows a 50 000-fold decrease in modulus upon heating by ∼10 °C. …”