<b>Uncovering the role of the yeast lysine acetyltransferase NuA4 in the regulation of nuclear shape and lipid metabolism</b> by Sarah Laframboise (18338787)

“…Disruption of the NuA4 complex results in 70% of cells displaying nuclear deformations and nearly 50% of cells exhibiting vacuolar fragmentation. …”

Celecoxib activates SIRT1 in a biochemical, <i>in silico</i> and <i>in vitro</i> cell-based assay. by Madhavi Annamanedi (580922)

“…Right - Model showing the interactions of Celecoxib with SIRT1 protein. C. A representative Western blot showing a dose-dependent decrease of Ac-H3K9 levels in presence of celecoxib. * p-value<0.01 compared to Control. …”

The formation of a negative image mediated by anti-Hebbian burst time dependent plasticity reduces signal but not noise correlations. by Benjamin Simmonds (682287)

“…<p><b>A</b>) One cycle of the 4 Hz sinusoidal stimulus (top, red trace) and synaptic weights (bottom, blue traces) as a function of time for (black traces from top to bottom), t = 0, t = 0.5 sec, t = 1 sec, t = 1.5 sec, t = 2 sec, t = 2.5 sec, t = 3 sec, t = 3.5 sec, t = 4 sec, t = 4.5 sec, t = 5 sec, t = 5.5 sec. …”

Anti-PCSK9 vaccine approach is boostable, and induced functional antibodies even after a single yearly re-boost. by Gergana Galabova (669355)

“…Note the slight loss of effect on TC levels over time (for example, by W42 and W50), and the induction of a significantly beneficial decrease following the re-boost immunization at W54. …”

Data_Sheet_1_Case Report: A Novel Mutation in NFKB1 Associated With Pyoderma Gangrenosum.PDF by Ran Fang (533948)

“…The functional analysis showed that the variant caused reduced phosphorylation of p105 and resulted in the decreased processing of p105 to p50. We conclude that the patient's symptoms were caused by dysregulation of the NF-κB signaling pathway.…”

Data from: Large subsurface carbon stocks in a long-term no-tillage site are vulnerable to potential mineralization by Qiuping Peng (20147290)

“…Soil cores were sampled to 153 cm depth at 25 locations representing 5 distinct soil series, a range in landscape positions, and a range in profile organic carbon contents. …”

Are Environmental Levels of Nonsteroidal Anti-Inflammatory Drugs a Reason for Concern? Chronic Life-Cycle Effects of Naproxen in Zebrafish by Susana Barros (586042)

“…The nonsteroidal anti-inflammatory drug naproxen (NPX) is among the most consumed pharmaceuticals worldwide, being detected in surface waters within the ng to μg/L range. Considering the limited chronic ecotoxicity data available for NPX in aquatic ecosystems, the present study aimed at evaluating its impact in the model organism Danio rerio, following a full life-cycle exposure to environmentally relevant concentrations (0.1 to 5.0 μg/L). …”

Image_1_Case Report: Mature Plasmacytoid Dendritic Cell Proliferation Associated With a Lymphoid Neoplasm.tiff by Fei Fei (794241)

“…Analysis of the pDC frequency in a separate cohort of T-ALL and control patients demonstrated that bone marrow pDCs are often decreased in patients with T-ALL compared to controls. …”

Image_3_Case Report: Mature Plasmacytoid Dendritic Cell Proliferation Associated With a Lymphoid Neoplasm.tiff by Fei Fei (794241)

“…Analysis of the pDC frequency in a separate cohort of T-ALL and control patients demonstrated that bone marrow pDCs are often decreased in patients with T-ALL compared to controls. …”

Dual action of novel 5-nitroguaiacol-based hydrazones: Targeting aldolase-a and inducing apoptosis in lung cancer by Mürvet Tümenci (22474400)

“…Compounds <b>3d</b> and <b>3k</b> exhibited selective and potent cytotoxicity (IC₅₀ = 10.24 µM and 4.99 µM, respectively) and strong aldolase A (ALDOA) inhibition at 10 µM (89.89% and 75.19%). …”

Study of <i>n</i>-Butylcyclohexane/Air Ignition over a Broad Range of Temperatures in Shock Tube by Dexiang Zhang (3554777)

“…<p>Measurements of ignition delay times for <i>n</i>-butylcyclohexane/air were performed over temperatures of 707–1458 K, pressures of 2.0, 5.0, and 15.0 atm, and equivalence ratios of 0.5, 1.0, and 2.0 in a heated shock tube. …”

In vivo analysis of the δ-GABA_A-Rs in the cerebellar granule layer in WT and TTR-/- mice. by Li Zhou (54356)

“…The total δ protein level showed no difference, while the biotinylated surface δ protein level decreased significantly in TTR-/- mice. Both total and the surface γ2 GABA_A-Rs have no difference between WT and TTR-/- mice. …”

Image_2_Case Report: Mature Plasmacytoid Dendritic Cell Proliferation Associated With a Lymphoid Neoplasm.tiff by Fei Fei (794241)

“…Analysis of the pDC frequency in a separate cohort of T-ALL and control patients demonstrated that bone marrow pDCs are often decreased in patients with T-ALL compared to controls. …”

Latency to reach the reward location during learning and testing. by Ilse Lorena Vargas-Vargas (17291085)

Sexual function after total laparoscopic hysterectomy or transabdominal hysterectomy for benign uterine disorders: a retrospective cohort by Yiqun Wang (2804704)

“…Both TLH and TAH had comparable negative effects on sexual function in women treated for benign uterine tumors in China, with a decreased frequency of sexual activity, reduced libido, orgasm dysfunction, and increased dyspareunia.…”

RRSV Pns10 and NlNDUFS1 co-localize in mitochondria of Sf9 cells and <i>N. lugens</i> midgut cells. by Lianshun Zheng (22086585)

Neurons born in a partial SE (pSE)-induced environment develop with modest changes in gross morphology and dendritic spines. by Johanna Jackson (325502)

“…<i>F</i>, Spine density on GFP+ dendrites from control and pSE animals, showing a decrease in number of mushroom spines. Means ± SEM, n = 7 for each group (morphological analysis), n = 8 control and n = 9 pSE group (dendritic spine analysis). *, P<0.05 unpaired t-test compared to control group. …”

VEGF induced-VE-cadherin extracellular domain cleavage is preceded by a Src-dependent VE-cadherin tyrosine phosphorylation. by Isabelle Vilgrain (497671)

“…<p>(A,B) HUVECs treated with VEGF (50 ng/mL) were analyzed for phosphotyrosinated-VE-cadherin in cell extracts (A) and VE-cadherin extracellular domain in conditioned medium (B): (A) VE-cadherin was immunoprecipitated from 200 µg of protein lysates and analyzed by SDS-PAGE and western blotting with the anti-phosphotyrosine antibody. …”

Deficiency of <i>irf2bp2a</i> specifically impairs neutrophils maturation in embryonic and adult zebrafish. by Shuo Gao (782511)

Image 1_Phage (cocktail)-antibiotic synergism: a new frontier in addressing Klebsiella pneumoniae resistance.tif by Chandrasekar Karthika (21255878)

“…Evaluation of phages as a cocktail demonstrated a substantial improvement in lytic ability, achieving complete (100%) lysis (at MOI 1) of clinical isolates compared to individual phages, achieving 50 and 25% lysis at MOI 1. …”