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9661
Potential binding regions mapped onto the crystal structure of AIMP3.
Published 2017“…<p>Upper left: Interface I in yellow, including residues Arg<sup>50</sup>, Thr<sup>68</sup>, Lys<sup>75</sup>, Ala<sup>91</sup>, Gln<sup>94</sup>, Gln<sup>95</sup>, Glu<sup>98</sup>, and Asp<sup>119</sup>. …”
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9662
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9663
Change of <i>SPDEF</i>, <i>MUC5AC</i>, and <i>MUC16</i> mRNA expression levels at follow-up points after rebamipide instillation treatment in SS-DE patients.
Published 2020“…<p>Least-square means (LS means ± 95% confidence interval) ware plotted for relative expression levels of <i>SPDEF</i>, <i>MUC5AC</i>, and <i>MUC16</i> mRNA at each observation point. (a) <i>SPDEF</i> mRNA expression levels were significantly increased at 2, 4, and 8 weeks compared with baseline values. …”
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9664
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9665
PRMT5 stabilizes vCyclin protein expression in a manner dependent on its methyltransferase activity.
Published 2024“…<p>(A-B) Effect of PRMT5 on vCyclin expression. First, HEK293T cells were cotransfected with fixed amounts of vCyclin expression plasmid and increasing amounts of PRMT5 expression plasmids. …”
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9666
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9667
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9668
Lipid Droplet-Binding Protein TIP47 Regulates Hepatitis C Virus RNA Replication through Interaction with the Viral NS5A Protein
Published 2013“…A single point mutation (W9A) in NS5A that disrupts the interaction with TIP47 but preserves proper subcellular localization severely decreased HCV RNA replication. …”
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9669
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9670
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9671
Table_2_Beginning of the Pandemic: COVID-19-Elicited Anxiety as a Predictor of Working Memory Performance.docx
Published 2020“…Moreover, across three assessment points spanning 5–6 weeks, COVID-19-related anxiety levels tended to decrease over time. …”
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9672
Table_1_Beginning of the Pandemic: COVID-19-Elicited Anxiety as a Predictor of Working Memory Performance.DOCX
Published 2020“…Moreover, across three assessment points spanning 5–6 weeks, COVID-19-related anxiety levels tended to decrease over time. …”
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9673
Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
Published 2017“…Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led to the identification of compound <b>7f</b> as a highly potent AMCase inhibitor (IC<sub>50</sub> values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150× against mCHIT1) with very good PK properties. …”
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9674
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9675
Activity of anti-mesothelin, anti-CD25 and anti-CD71 immunotoxins in KLM-1 and KLM-1-R.
Published 2015“…Growth inhibition was evaluated with an ATP cell viability assay. With IC<sub>50</sub>s below 10 ng/ml, KLM-1 is sensitive to the anti-mesothelin RITs, which is not the case for KLM-1-R (IC<sub>50</sub>s > 1 μg/ml). 1 μg/ml LMB-2 decreased cell viability, indicating that this RIT concentration induces non-specific uptake. …”
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9676
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9677
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9678
Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo
Published 2012“…In mice, administration of 4 mg/kg WF-A daily for 2 weeks reduced isoproterenol-induced myocardial fibrosis by 50%. …”
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9679
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9680
Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation
Published 2012“…Western blotting and immunohistochemistry of <em>AnxA2<sup>−/−</sup></em> tissues revealed that the LDLR was decreased by ∼50% in extrahepatic tissues, such as adrenals and colon. …”