Tumor microenvironment facilitates the emergence of high levels of drug resistance. by Feng Fu (218124)

“…In the absence of drugs, both proliferation and turnover rates of cancer cells decrease with <i>x</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004142#pcbi.1004142.ref022" target="_blank">22</a>]: birth rate <i>β</i>(<i>x</i>) = <i>b</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>) and death rate <i>α</i>(<i>x</i>) = <i>d</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>), where the parameter <i>τ</i>_<i>g</i> is the characteristic length scale of spatial decay in proliferation and turnover rates. …”

RER1 expression significantly reduces αSyn levels. by Hyo-Jin Park (4233949)

FGF2 regulates otic gene expression through the MAP kinase pathway. by Lu Yang (30847)

“…Trigeminal level ectoderm was cultured with 50 ng/ml FGF2 in the presence or absence of 20 µM U0126. …”

Gel filtration and EMSA analysis of the WT N protein purified from HEK293S GNTI- cells. by Amanda Jack (11547638)

“…<b>(F)</b> EMSA using no RNA, 10 nM 0–5 kb viral RNA, and 50 ng/μL polyC RNA and decreasing concentration of N protein. …”

Increased aggregation propensity enhances Pept-in antimicrobial potency by promoting Pept-in accumulation and IB formation. by Guiqin Wu (760045)

“…<p><b>A:</b> MIC (left Y-axis) against <i>E</i>. <i>coli</i> BL21 and Tango score (right Y-axis) of P2 derivatives generated by alanine scanning of the APR region. …”

Axonal features and growth of elongating and arborizing Purkinje cells in embryonic or postnatal cultures. by Annarita de Luca (370802)

“…<p>(A) The growth rate of both embryonic (E17) and postnatal (P0) elongating (EL) cells progressively decreases during the time <i>in vitro</i>, but postnatal axons lengthen faster than their embryonic counterparts during the first week in culture (two way ANOVA, main effect of population P = 0.03). …”

Effect of H3 haplotype on serum HDL-cholesterol levels in women. by Heidi J. Silver (324097)

“…In obese females, calorically restricted (−15% kcal) HF diet increased HDL-C from 50.11±11.60 mg/dl to 52.29±10.38 mg/dl in H3 haplotype carriers and decreased HDL-C from 47.99±12.90 mg/dl to 45.49±8.95 mg/dl in H3 non-carriers.…”

IPSE exhibits dose-dependent heptotoxicity that is neutralized by specific monoclonal antibody. by Maha-Hamadien Abdulla (67713)

Histology of the myocardium and WAT of mice during acute infection (n = 5, minimum five images/section were analyzed). by Fnu Nagajyothi (37087)

“…Each class was graded on a five point scale ranging from 0 to 4+ as discussed in Method section, and presented as a bar graph. …”

Parasitemia titration results. by Paul Lebel (11250722)

“…Missing markers correspond to points where no parasites were located in the 300 cell sample. …”

Experimental tasks and model framework. by Jana Masselink (16764941)

“…When saccades are performed repetitively to the same, non-stepping target, oculomotor fatigue occurs, i.e. peak velocity declines, which is usually compensated by an increase of saccade duration.…”

Effects of synaptic transmission on network bursts. by Davide Lonardoni (4282318)

Image_1_Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy.tif by Irene Campi (10531166)

Astrocytic volume changes in the cortex of GFAP/EGFP and GFAP/EGFP/α-Syn^−/− mice during hyperosmotic stress. by Miroslava Anderova (155561)

High-Throughput Screening of Australian Marine Organism Extracts for Bioactive Molecules Affecting the Cellular Storage of Neutral Lipids by James Rae (210551)

“…The activity of heterofibrin A1 was dose dependent with 20 µM inhibiting LD formation and triglyceride accumulation by ∼50% in the presence of 50 µM oleic acid. …”

Hit expansion around chloroxine. by Sam Barker (4832121)

“…This modification causes a significant decrease in this compound’s activity as a co-treatment with ceftazidime, with a <i>p</i>IC50 ≈ 3.4. 5,7-dichloro-2-methyl-8-quinolinol differs from chloroxine by addition of a methyl group in the 2-position (B). …”

Dissociation, and not specific actions of Trypsin-EDTA, acts to suppress neurectoderm formation. by James N. Hughes (319868)

“…Error bars represent sem. (a) denotes a decrease compared to MEDII⁻/Dissociation⁻ where p<0.01. …”

Long-term growth curves of nucleus pulposus chondrocytes (NPCs) obtained from donors of various ages. by Jun-Seok Lee (181420)

“…<p>Plots of cumulative population doubling levels (PDLs) against time in culture (A) and passage number (B). The cumulative PDLs of NPCs from the young group (patients in their 30s, 40s, and 50s) were relatively higher than those from the old group (patients in their 60s and 70s). …”

The reduced expression of ZBRK1 is inversely correlated with the increased expression of KAP1 in cervical cancer specimens. by Li-Fang Lin (449199)

“…<p><b>A</b>, All tumor specimens from 50 patients with different stages of cervical cancer were obtained from surgically resected tissues. …”

Training at maximal power in resisted sprinting: Optimal load determination methodology and pilot results in team sport athletes by Matt R. Cross (5089268)

“…<div><p>Aims</p><p>In the current study we investigated the effects of resisted sprint training on sprinting performance and underlying mechanical parameters (force-velocity-power profile) based on two different training protocols: (i) loads that represented maximum power output (<i>L</i>_opt) and a 50% decrease in maximum unresisted sprinting velocity and (ii) lighter loads that represented a 10% decrease in maximum unresisted sprinting velocity, as drawn from previous research (<i>L</i>₁₀).…”