Doxorubicin Impairs the Insulin-Like Growth Factor-1 System and Causes Insulin-Like Growth Factor-1 Resistance in Cardiomyocytes by Patrizia Fabbi (305756)

“…Doxorubicin also dose-dependently induced p53, which is known to repress the transcription of <i>IGF1R</i> and induce that of <i>IGFBP3</i>. Pre-treatment with the p53 inhibitor, pifithrin-α, prevented apoptosis and the changes in IGF-1R and IGFBP-3 elicited by doxorubicin. …”

Young Sprague Dawley rats infected by <i>Plasmodium berghei</i>: A relevant experimental model to study cerebral malaria by Sokhna Keita Alassane (4268356)

“…However, their relevance to mimic human pathogenesis is largely debated. Here we study an alternative cerebral malaria model with an experimental <i>Plasmodium berghei</i> Keyberg 173 (K173) infection in Sprague Dawley rats. …”

A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089 by Khushboo Sharma (686941)

“…Sensitization to radiation in H1299 NSCLC cells was evident only when TP53 was induced in otherwise <i>tp53</i>-null H1299 NSCLC cells. Sensitization was not associated with increased DNA damage, decreased DNA repair or an increase in apoptosis, necrosis, or senescence. …”

DataSheet_1_O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis.pdf by Junghwa Seo (10066531)

“…Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O-GlcNAcylation contributes to the regulation of necroptotic cell death are poorly understood. In this study, we reveal that O-GlcNAcylation of RIPK1 (receptor-interacting protein kinase1) was decreased in erythrocytes of the mouse injected with lipopolysaccharide, resulting in the acceleration of erythrocyte necroptosis through increased formation of RIPK1-RIPK3 complex. …”

Image_1_Augmenting the Effectiveness of CAR-T Cells by Enhanced Self-Delivery of PD-1-Neutralizing scFv.tif by Yu Ping (5028764)

“…Herein, we designed CAR-T cells than could secret α-PD-1 scFv by themselves. …”

DataSheet_1_CTNNB1 Alternation Is a Potential Biomarker for Immunotherapy Prognosis in Patients With Hepatocellular Carcinoma.pdf by Lin Chen (54305)

“…</p>Conclusions<p>In this study, we found CTNNB1-MUT to be a potential biomarker for HCC immunotherapy patients, because it identified those patients are less likely to benefit from ICIs.…”

Data_Sheet_1_Increased Plasma Heme Oxygenase-1 Levels in Patients With Early-Stage Parkinson’s Disease.docx by Wenhua Sun (6715838)

“…The right hippocampal volume was decreased in the subset of PD patients with high HO-1 levels (p < 0.05). …”

Video_1_Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.AVI by Ana Dios-Esponera (6422411)

“…Additionally, we report an increase in L-selectin shedding in Pak1-deficient T cells, which correlates with a decrease in the recruitment of calmodulin to the cytoplasmic tail of L-selectin during T cell activation. …”

Image_1_cDC1 Dependent Accumulation of Memory T Cells Is Required for Chronic Autoimmune Inflammation in Murine Testis.tif by Yuchao Jing (11182605)

“…In addition, under homeostatic conditions, CD8⁺ T cells are the dominant subgroup and have different phenotypic characteristics from CD4⁺ T cells. We found that cDC1, but not cDC2, is necessary for the presence of T cells in the testis under physiological state. …”

DataSheet1_Cav1.4 congenital stationary night blindness is associated with an increased rate of proteasomal degradation.PDF by Tal T. Sadeh (10044455)

“…To establish the underlying pathomechanism, we investigated 10 clinically derived CACNA1F missense variants located across pore-forming domains, connecting loops, and the carboxy-tail domain of the Ca_v1.4α subunit. …”

Visualization of a classified 3D volume. by Amrita Das Gupta (17364749)

Selection for rare alleles that increase the rate of (a) monandry or (b) selfing. by Michael Francis Scott (5447600)

Image_1_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

DataSheet1_Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice.ZIP by Yanrong Long (14138718)

“…In hyperoxic lung ECs of neonatal mice, we detected upregulated fibroblast growth factor receptor 1 (FGFR1) expression, accompanied by upregulation of the classic downstream signaling pathway of activated FGFR1, including the ERK/MAPK signaling pathway and PI3K-Akt signaling pathway. …”

Values for all quantifications. by Sravya Paluri (5475260)

“…<i>In vitro</i>, and <i>in vivo</i> studies in the epithelia of the <i>Drosophila</i> wing imaginal discs identified microRNA-184 (miR-184) as a potential regulator of a subset of pleated septate and tricellular junction proteins. …”

pone.0328862.t001 - by Sravya Paluri (5475260)

“…<i>In vitro</i>, and <i>in vivo</i> studies in the epithelia of the <i>Drosophila</i> wing imaginal discs identified microRNA-184 (miR-184) as a potential regulator of a subset of pleated septate and tricellular junction proteins. …”

Video1_Novel Biallelic Variant in the BRAT1 Gene Caused Nonprogressive Cerebellar Ataxia Syndrome.MP4 by Yiming Qi (780014)

“…Subsequent prenatal diagnosis for these two variants guided the parents to reproduce. We expand the phenotypic spectrum of BRAT1-associated disorders by first reporting the pathogenic synonymous variant of the BRAT1 gene, resulting in clinical severity that is mild compared to the severe phenotype seen in RMFSL. …”

Image_1_Alterations of NURR1 and Cytokines in the Peripheral Blood Mononuclear Cells: Combined Biomarkers for Parkinson’s Disease.TIF by Tianbai Li (6020375)

“…Since NURR1 was reported to have regulating effects on neuroinflammation, we assessed the expression levels of cytokines (TNF-α, IL-1β, IL-4, IL-6, and IL-10) in the PBMCs of PD and controls (HC and NDC). …”

Influence of Additional Gaussian Noises on Mixed Quantum-Classical Nonadiabatic Dynamics Simulations of Photoisomerization of <i>cis</i>-Azobenzene by Zihan He (3702544)

“…To address this concern, we perform surface hopping and Ehrenfest mean field dynamics simulations on the photoisomerization of <i>cis</i>-azobenzene and investigate the influence of additional noises on the collective results by introducing Gaussian random numbers into on-the-fly electronic structure calculations at each dynamic step. …”

Acetylation of Chromatin-Associated Histone H3 Lysine 56 Inhibits the Development of Encysted <i>Artemia</i> Embryos by Rong Zhou (138287)

“…We found that the level of H3K56ac on chromatin increased during diapause formation, and decreased upon diapause termination, remaining basal level throughout subsequent embryonic development. …”