Quizartinib decreased [¹²⁵I]-IAAP photolabeling of both ABCB1 and ABCG2 but inhibited ATPase activity of only ABCG2 at high concentrations. by Jasjeet Bhullar (445431)

Simultaneous silencing of isoamylases ISA1, ISA2 and ISA3 by multi-target RNAi in potato tubers leads to decreased starch content and an early sprouting phenotype by Stephanus J. Ferreira (4249219)

Knockdown of Smad3 led to increased expression and phosphorylation of IRS-1, which contributed to Smad3 knockdown-induced increased proliferation and decreased apoptosis under stre... by Katie L. Bailey (3929966)

The synthetic CB1R agonist WIN55,212–2 leads to decreased cell viability and increased G1 arrest in pancreatic β-cell lines. by Jihye Kim (344025)

Variations in the prevalence of episiotomy in France between 2010 and 2021 according to the classification for episiotomy practices. by Raphaele Houlbracq (20558509)

Propofol increased the number of the hippocampal pyramidal neurons and decreased the expression of the LC3-II protein and the number of lysosomes and autophagosomes in the ischemic... by Derong Cui (326839)

“…<p>I/R was induced by 2-vessel occlusion. Propofol 10, 50, or 100 mg/kg was administrated intraperitoneally and 3-MA (600 nM) was administered intracerebroventricularly 10 min after the onset of ischemia. (1) Sham-operated group (control group, Cont); (2) I/R group; (3) I/R+ 3-MA 600 nmol group; (4) I/R + propofol 10 mg/kg group; (5) I/R + propofol 50 mg/kg group; (6) I/R + propofol 100 mg/kg group; (7) I/R + vehicle (intralipid, 100 mg/kg) group. …”

Treatment with NaOH decreases ubiquitination of D_4.2R WT and D_{4.2 4KR}R mutant. by Kamila Skieterska (841014)

Supplementary Data S2 from SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance by Kristen Jensen-Pergakes (15090247)

HbA1c, BMI and Lipid levels of study participants (n = 382). by Habiba I. Ali (10451382)

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Induction of histones H3 and H4 hyper-acetylation and decreased histone H3-lys27 trimethylation follow GBM cell line treatment with HYP. by Naama Dror (459005)

Estimates of the differencing parameter, d, in Eq (1). by Luis Alberiko Gil-Alana (14659817)

PGRP-LC in the gut promotes ageing by <i>A</i>. <i>persici</i>. by Taro Onuma (15195377)

PADK decreases intra- and extracellular 6E10 staining in APPswe/PS1ΔE9 (APP-PS1) mice of 20–22 months. by David Butler (349975)

miR-184 sensor expression across a range of tissues. by Sravya Paluri (5475260)

<i>Ss</i> infection is associated with decreased plasma levels of IL-2, IL-7 and IL-15 and enhanced plasma levels of IL-4 and IL-9. by Anuradha Rajamanickam (5278013)

Table_1_Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection.DOCX by Lerato N. Ndlovu (9315464)

TLR2 deficiency decreased TGF-β1 expression, phosphorylated Smad2/3 and myofibroblasts activation induced by <i>C</i>. <i>sinensis</i>. by Yuru Wang (846969)

Table_1_Prenatal exposure to inflammation increases anxiety-like behaviors in F1 and F2 generations: possible links to decreased FABP7 in hippocampus.DOCX by Jing Chen (4762)

“…<p>Anxiety disorder has a high prevalence, and the risk of anxiety increases with age. …”