An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study by Justin B. Echouffo-Tcheugui (9388233)

“…In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).…”

Image_1_Effects of Perioperative Dexmedetomidine on Immunomodulation in Uterine Cancer Surgery: A Randomized, Controlled Trial.tif by Jin Sun Cho (11710808)

“…Objective<p>Dexmedetomidine has sympatholytic, anti-inflammatory, and analgesic effects and may exert anti-tumor effect by acting on α2A adrenoreceptor. We investigated whether perioperative dexmedetomidine preserves immune function in patients undergoing uterine cancer surgery.…”

Data_Sheet_1_Therapy-Induced Electrophysiological Changes in Primary Progressive Aphasia: A Preliminary Study.docx by Jara Stalpaert (9234844)

“…In the two patients that did not receive SLT, an increased delay in 50% and a decreased mean amplitude in 25% of the measured ERP components were found. …”

A Cross-Sectional Study of the Microeconomic Impact of Cardiovascular Disease Hospitalization in Four Low- and Middle-Income Countries by Mark D. Huffman (217541)

“…Catastrophic health spending (CHS) was present in >50% of respondents in China, India, and Tanzania. …”

DataSheet1_A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing.PDF by Lucas Nik Reger (14632742)

“…The novel process showed increased productivity (+217%) as well as longer cultivation duration, in comparison to a standard FB with a significantly lower media consumption per produced product (−50%) and a decreased need for process monitoring, in comparison to a perfusion cultivation. …”

Datasheet1_Fever management in children and insights into fever of unknown origin: a survey among Italian pediatricians.pdf by Elena Chiappini (304802)

Data Sheet 1_Cytomegalovirus infection in infants with biliary atresia in China: a multi-center investigation study.docx by Yilin Zhao (487866)

“…</p>Conclusion<p>Among the 1,276 infants with BA in this cohort, 31.3% (399 cases) had concomitant CMV infection, representing a decrease compared to previous data. CMV-IgM played a crucial role in the detection of the infection. …”

Image_1_TnP Peptide Suppresses Experimental Autoimmune Encephalomyelitis (EAE) in a Preclinical Mouse Model.pdf by Carla Lima (428557)

“…We have shown that TnP possesses a disease suppressive function in EAE, ameliorating disease severity by 40% and suppressing the accumulation of T helper (Th)1- and Th17-producing lymphocytes (by 55% and 60%, respectively) in CNS along with activated microglia/macrophages populations (by 33% and 50%, respectively), and also conferred a protective effect anticipating the remyelination process to day 66 compared to day 83 of untreated cuprizone-mice. …”

Video_3_Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.MP4 by Lise Heylen (11561266)

Video_2_Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.MP4 by Lise Heylen (11561266)

Primary and secondary outcome definitions. by Andrew L. Mariotti (17457504)

“…Statistically significant decreases in SSSI of 2.5, 2.1, and 2.2 minutes for upper, lower, and dual GI procedures were observed when using MAC protocols. …”

p75^NTR small molecule ligands protect neurons from Aβ-induced death. by Tao Yang (184280)

“…<p>6–7 DIV hippocampal, cortical and septal neurons were exposed to: culture medium alone (CM); CM containing 10 µM Aβ(S), a control peptide containing Aβ(1-42) residues in a scrambled sequence; 10 µM Aβ alone or with NGF (100 ng/ml , ∼4 nM), LM11A-24, -31, or -36 (100 nM). …”

VER-155008 caused a significant reduction in viral transcripts in HEK-293T rKSHV.219 cells. by Belinda Baquero-Pérez (706834)

“…(C) At 4 h AcD treatment <i>SRAG</i> mRNA levels were reduced by 50% showing a relatively short stability. (D) <i>H2A</i>.…”

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition by Naping Hu (2614399)

“…The aim of this study was to investigate whether Hydroxysafflor yellow A (HSYA) can preserve renal function by inhibiting the progression of renal fibrosis and the potential mechanisms.…”

Table_1_Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.xlsx by Jun Tang (32983)

“…The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47–0.93); p = 1.81E−02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50–0.97); p = 3.00E−02). …”

Table_3_Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.xlsx by Jun Tang (32983)

“…The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47–0.93); p = 1.81E−02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50–0.97); p = 3.00E−02). …”

Data_Sheet_1_Biocontrol Potential of a Novel Endophytic Bacterium From Mulberry (Morus) Tree.docx by Sen Xie (8349420)

“…Moreover, when applied to the generalist herbivore Spodoptera litura, ZJU1 was sufficient to reduce the pest survival rate below 50%. A previously undiscovered crystal toxin (Cry10Aa) could contribute to this insecticidal effect against notorious lepidopteran pests. …”

<i>Toxoplasma gondii</i> serine-protease inhibitor-1: A new adjuvant candidate for asthma therapy by Ariadna S. Soto (4538035)

“…This effect was accompanied by a lung resistance reduction of 26.3% and 50.3% respectively. …”

Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates by Kristina Hacker (773425)

“…<div><p>The importance of the organic cation transporter OCT2 in the renal excretion of cationic drugs raises the possibility of drug-drug interactions (DDIs) in which an inhibitor (perpetrator) drug decreases OCT2-dependent renal clearance of a victim (substrate) drug. …”

Table 1_Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.xlsx by Yi Kang (387134)

“…</p>Result<p>MR analysis indicated that glucosamine was associated with increased cognitive performance (p = 8.46E-04), FIS (p = 7.50E-04), ALM (p = 6.45E-08), WBFM (p = 1.97E-03), usual walking pace (p = 2.55E-07), and moderate to vigorous physical activity levels (p = 3.29E-03), but associated with decreased FA risk (p = 3.77E-05) and DNA methylation GrimAge acceleration (p = 0.001). …”