BEZ235 decreases p-AKT(Thr308), p-S6 ribosomal protein (Ser235/236), caspase-3, and retards the growth of ATC flank xenograft tumors without significant toxicity in nude mice. by Shu-Fu Lin (126854)

Effect of thalidomide on CUL5 and NEDD8 localization in control and si-transfected HUVEC at 24 hours after treatment. by Bryan Kunkler (5204327)

Genetic characterization of <i>Mycoplasma pneumoniae</i> isolated in Osaka between 2011 and 2017: Decreased detection rate of macrolide-resistance and increase of <i>p1</i> gene ty... by Chihiro Katsukawa (6264050)

“…However, in 2015 and after, the detection rate of MRMP decreased significantly and did not exceed 50%. Genotyping of the <i>p1</i> gene of these isolates showed that most of MRMP strains harbored type 1 <i>p1</i> gene. …”

Referenced studies with functional connectivity correlations with intensity and/or duration of chronic pain. by Peter A. Pahapill (8468607)

Image_1_IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt.TIF by Renée H. Fiechter (10230473)

“…For some cell types this was even more pronounced at week 24, but clearly synovial inflammation was incompletely resolved. IL-17A and F, TNF, IL-6, IL-8, and IL-12p40 were not significantly downregulated in qPCR analysis of W12 total biopsies, only MMP3 and IL-23p19 were significantly decreased. …”

LTP modulates steady-state inactivation of A-type K⁺ currents. by Sung-Cherl Jung (261358)

“…Scale bars, 200 pA, 50 ms. The A-current available for activation at −60 mV was significantly decreased only in the neurons receiving paired stimulation 10 min after conditioning stimulation (a red arrow). …”

Binding of PregOBP56a to <i>N</i>-phenyl-1-naphthylamine (1-NPN) and potential ligands derived from chicken meat. by Yuko Ishida (104789)

“…Due to low binding to PregOBP56a, the IC₅₀ of other test competitors was not obtained.…”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…Evaluations of toxicity showed no neurotoxic effects and a high safety margin (LD₅₀ > 2000 mg/kg). …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…Evaluations of toxicity showed no neurotoxic effects and a high safety margin (LD₅₀ > 2000 mg/kg). …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…Evaluations of toxicity showed no neurotoxic effects and a high safety margin (LD₅₀ > 2000 mg/kg). …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…Evaluations of toxicity showed no neurotoxic effects and a high safety margin (LD₅₀ > 2000 mg/kg). …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…Evaluations of toxicity showed no neurotoxic effects and a high safety margin (LD₅₀ > 2000 mg/kg). …”

Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation by Shahin Ahmadi (9334861)

“…The outliers and promoters of increase/decrease of logEC₅₀ are extracted and the mechanistic interpretation of effective descriptors for the model is also offered.Highlights</p><p>Global SMILES-based QSAR model was developed to predict the toxicity of ILs.…”

DataSheet1_CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.docx by Chao Fang (456315)

“…In particular, individuals with the GG genotype had a 4-fold higher risk of heart rate abnormality than carriers of the T allele (OR = 4.32, 95% CI: 1.96–9.50, p = 0.00027).…”

Alteration in overall structure and the helicity of the peptide binding domain (PBD). by Koushik Roy (193484)

Conceptualization of changes in <i>STM</i>_<i>FCS</i> and pain levels seen in ESCRPS FBSS patients. by Peter A. Pahapill (8468607)

CUL5 protein localization in HUVEC treated with increasing doses of thalidomide. by Bryan Kunkler (5204327)

Effect of thalidomide on CUL5 and NEDD8 localization in HUVEC. by Bryan Kunkler (5204327)

“One Health Cosmos”. by Tai Xie (4416988)

RXR agonists suppressed KIF4-mediated surface NTCP transport. by Sameh A. Gad (12269979)