Supplementary Material for: A Prospective, Randomized, Open-Label Trial of Atorvastatin versus Rosuvastatin in the Prevention of Contrast-Induced Acute Kidney Injury, Worsened Rena... by Toso A. (8870774)

“…<b><i>Methods:</i></b> In this open-label, noninferiority study, we compared changes in renal function in 709 NSTE-ACS patients randomized to atorvastatin (80 mg upon admission followed by 40 mg/day) or rosuvastatin (40 mg upon admission followed by 20 mg/day). The primary end point was AKI (increase in serum creatinine ≥0.5 mg/dL or ≥25% above baseline within 72 h). …”

Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents by Yini Wang (410389)

“…Comparing 8a-treated CCRF-CEM leukemia cells with vehicle control (DMSO), 23 distinct metabolites involved in five metabolic pathways were identified. Metabolites from glutathione (GSH) and glycerophospholipid metabolism were investigated in detail, and results showed that GSH level and the reduced/oxidized glutathione (GSH/GSSG) ratio were significantly decreased in 8a-treated cells, while L-cysteinyl-glycine (L-Cys-Gly) and glutamate were greatly increased. …”

Impact of an Educational Program to Reduce Healthcare Resources in Community-Acquired Pneumonia: The EDUCAP Randomized Controlled Trial by Jordi Adamuz (812449)

“…The frequency of the composite primary end point was 23.5% following the individualized program and 42.9% following the conventional information (difference, -19.4%; 95% confidence interval, -6.5% to -31.2%; P = 0.003).…”

Table_1_Effect of Abdominal Circumference on the Irradiated Bowel Volume in Pelvic Radiotherapy for Rectal Cancer Patients: Implications for the Radiotherapy-Related Intestinal Tox... by Gang Wang (36685)

“…Weight, height, AC, and body mass index (BMI) were used as the research objects, and the irradiated bowel volume at different dose levels (V10, V20, V30, V40, V50) was selected as the outcome variable. …”

Tn-Seq identifies genes required or detrimental for the growth of <i>S</i>. <i>aureus</i> under low pH. by Catrin M. Beetham (17797675)

“…The growth of two transposon mutant pools (library A and library B) in TSB pH 7.3, pH 5.5, or pH 4.5 medium was monitored by taking OD₆₀₀ readings at defined time points. …”

MVEC-EVs promoted OPC survival, proliferation, and motility in a dose-dependent manner. by Masashi Kurachi (106280)

“…(A) The proportion of pyknotic nuclei decreased at doses ≥ 50 μg/ml. Results are shown as mean ± SE (N = 8 in each condition). …”

Acute Hypoglycemia Induces Retinal Cell Death in Mouse by Martine Emery (215947)

“…We then isolated retinas from each group at different time-points after the clamp to analyze cells apoptosis and genes regulation. …”

Hydrated Alkali Atoms on Copper(111): A Density Functional Theory Study by Alejandro Pérez Paz (9016370)

“…Beyond 5 coordinated water molecules, the alkali adatom becomes saturated, and water adsorption sets in on the Cu(111) surface with the expected decrease in the work function of the system, as measured in two-photon photoemission spectroscopy (2PPE) experiments. …”

Effect of AZT and LAC treatments on brain oxidative stress in newborn and adult mice. by Anna Rita Zuena (89723)

Microstructure and Wear Resistance of ZrC-ZrB2 /Ni Composite Coatings Prepared by Plasma Transferred Arc Cladding by Tian-guo Guan (6675545)

DNMT3L was found within the adult testis and mature sperm. by Natasha M. Zamudio (225855)

“…Results are presented as means ± SEM. <b>*</b> Indicates a statistically significant decrease in relative intensity of DNMT3L with a p≤0.05.…”

EHEC-Hly-containing OMVs cause DNA laddering and formation of TUNEL-positive nuclei. by Martina Bielaszewska (79970)

“…<p>(<b>A, B</b>) HBMEC (<b>A</b>) and Caco-2 cells (<b>B</b>) were incubated with EHEC-Hly-containing OMVs (TA50 or 8033; 100 ng of EHEC-Hly) or EHEC-Hly-free OMVs (TA51 or 8033c; 20 µg of OMV protein) for 48 h. …”

Mycolactone induces IL-1β secretion by activating the NLRP3/1 inflammasome pathway. by M. Foulon (9873663)

“…</b> The addition of 5 mM or 50 mM KCl to the medium decreased and abolished IL-1β secretion, respectively, in the presence of either mycolactone or CPPD. …”

Stomatal development and responses are impaired in specific <i>crks</i>. by Gildas Bourdais (502310)

“…Complementation of the <i>crk2</i><b>(B)</b>, <i>crk5</i><b>(C)</b> or <i>crk45</i><b>(D)</b> mutants restored a wild type-like water loss phenotype as interpreted from decrease of fresh weight of excised rosettes. …”

Pedigrees with copy number variations (CNVs). by Pooja Biswas (793361)

“…<p>Five unique structural variants were identified in <i>EYS</i>, <i>LCA5</i>, <i>CERKL</i>, <i>PRPH2</i>, and <i>CNGB3</i> in five different pedigrees, one with dominant macular degeneration and four with recessive retinal degeneration. …”

SEA binds DC-SIGN and can block <i>trans</i>-infection of CD4 T-lymphocytes but not <i>cis</i>-infection. by Emily EIM Mouser (7348559)

“…<b>(D)</b> SEA’s effect on <i>trans</i>-infection was determined by pre-incubating Raji DC-SIGN cells with 1μg/ml SEA for 2h and subsequently adding SF162 (TCID₅₀ 5000) or LAI (TCID₅₀ 500). Viral outgrowth in Raji DC-SIGN—CD4⁺ T-lymphocyte co-cultures was monitored through measuring p24 levels in culture supernatant. …”

LIS1 controls macrophage proliferation, differentiation and survival via modulating M-CSF and RANKL signaling pathways and NFATc1. by Shiqiao Ye (198070)

“…LUC-sh and LIS1-sh transduced BMMs were serum and cytokine starved for 12 hours before stimulated with 50 ng/ml M-CSF for indicated time. ERK and AKT activation were detected by western blots with anti-phospho-ERK (p-ERK) and anti-phospho-AKT (p-AKT) antibodies. …”

Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarizationactivated channel by Yu-Long Li (311230)

“…<p>  </p> <p><strong>Aim:</strong> Although dysfunction of arterial baroreflex occurs in human and animal models of type-1 diabetes (T1D), the mechanisms involved in the impairment of the baroreflex still remain unclear. The nodose ganglion (NG) contains the cell bodies of the aortic baroreceptor (AB) neurons. …”

Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells by Ryo Matoba (1609)

“…In this study, EMT-associated formation of cellular aggregates was induced by co-stimulation of cultured ARPE-19 cells with tumor necrosis factor (TNF)-α (10 ng/ml) and transforming growth factor (TGF)-β₂ (5 ng/ml). 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), a potent activator of AMPK, significantly suppressed TNF-α and TGF-β₂-induced cellular aggregate formation (p < 0.01). …”

Probing the Sensitivity of the Orbitrap Lumos Mass Spectrometer Using a Standard Reference Protein in a Complex Background by Michaella J. Levy (1564081)

“…Furthermore, the total number of proteins identified from decreasing starting amounts of whole cell extracts was determined. …”