Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Med7 is required for hyphal development in <i>C. albicans</i>. by Faiza Tebbji (141832)

Differences in NIHSS score every 24 hours in patients with low, normal and high temperatures. In patients with low temperature (<36°C) within 24 hours a significant decrease in the... by Miguel Blanco (55945)

PDRN upregulates SIRT1 protein expression in HaCaT cells exposed to UVB or H₂O₂. by Jingjing Chen (293564)

PDRN upregulates SIRT1 protein expression in HaCaT cells exposed to UVB or H₂O₂. by Jingjing Chen (293564)

Combinatorial effect of C-10 and microRNAs on its target genes. by Chatla Srinivas (823944)

“…<p>(A and B) MCF-7 and MDA-MB-231 cells were transfected with microRNA-15, 16, 17 and 221 for 24 h followed by treatment with Cisplatin, Etoposide or C-10 and incubated for 24 h. Western blot analysis showing decrease in levels of Bcl-2, STAT3 and VEGF proteins. …”

Dietary Macronutrient Composition Directs ChREBP Isoform Expression and Glucose Metabolism in Mice by Tara Jois (3592874)

“…</p><p>We compared the effects of diets with high complex carbohydrate, high fat, or a normal chow on ChREBP expression and metabolic parameters in C57BL/6 mice. We found that diets high in fat decrease ChREBP expression in adipose tissue, but isocaloric diets high in carbohydrate have no effect. …”

Removal of specific N-glycans can alter neutralization potency and completeness. by Sabrina Lusvarghi (2329267)

“…<p>(A) Structure of SARS-CoV-2 spike in the closed conformation complexed with Bebtelovimab (PDBID:7MMO, yellow), C135 (PDBID: 7K8Z, green) and S309 (red, PDBID: 6WPS). …”

PRV UL4 also promotes AIM2-inflammasome activation. by Xiaohua Zhang (350570)

Related to Fig 2. by Amy E. Schade (15368259)

K2 increases intracellular killing of <i>K</i>. <i>pneumoniae</i> by <i>kil1</i> KO and <i>kil2</i> KO cells. by Estelle Ifrid (10076719)

Supplementary Material for: Morphofunctional Effects of C5 Convertase Blockade in Immune Complex-Mediated Membranoproliferative Glomerulonephritis: Report of Two Cases with Evidenc... by Carrara C. (6480752)

“…Glomerular inflammation improved and median (interquartile range) glomerular staining for C5b-9 decreased in both cases: from 23.6 to 18.2% (<i>p</i> = 0.021) in the patient who achieved remission and from 15.8 to 10.7% (<i>p</i> = 0.019) in the patient with persistent proteinuria. …”

Table 1_GLP1 receptor agonists and SGLT2 inhibitors for the prevention or delay of type 2 diabetes mellitus onset: a systematic review and meta-analysis.docx by Farah Ghobar (22480732)

“…Background<p>SGLT-2 inhibitors (SGLT-2i) and GLP-1 receptor agonists (GLP-1 RA) are two widely used classes of medications in the treatment of diabetes, each demonstrating significant efficacy and adoption. …”

Enhancement of <i>atl</i>^<i>2</i> poly-UB aggregate phenotype by TrpA1 activation. by Saurabh Srivastav (9585817)

Characteristics of the sample of children in the comparison of two measures of a clean face. by Sheila K. West (7245476)

Palmitate-induced cell death is enhanced by RSV. by Cristina Rojas (667363)

“…Palmitate-treated cells were also co-incubated with increasing concentrations of RSV as follows: <b>B</b>) 25 µM RSV; <b>C</b>) 50 µM RSV and <b>D</b>) 100 µMRSV. A further decrease on HepG2 viability compared with treatments with palmitate alone was observed in the 50 µM RSV and 100 µM RSV assays. …”