Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks by Sofia Benfeito (4345591)

“…Although the lipophilic triphenylphosphonium (TPP⁺) cation is widely used to target antioxidants to mitochondria, TPP⁺-based derivatives have shown cytotoxicity in several biological <i>in vitro</i> models. We confirmed that <b>Mito.TPP</b> is cytotoxic to both human neuronal (SH-SY5Y) and hepatic (HepG2) cells, decreasing intracellular adenosine triphosphate (ATP) levels, leading to mitochondrial membrane depolarization and reduced mitochondrial mass after 24 h. …”

PIK3C3 promotes <i>Shigella flexneri</i> cell-to-cell spread in HT-29 cells. by Steven J. Rolland (21376879)

Comparison of simulation results. by Bo Xie (669374)

“…The results indicate that during the bending process of ordinary and reinforced cables in the cable drag system, the tensile force between the cable clamps increases from approximately 28 N and 37 N to a maximum value of 133 N and 146 N, respectively, before decreasing to around 57 N and 66 N. At the connection point between the drag system and the shearer, the tensile force between the cable clamps fluctuates and increases, reaching a maximum value of 925.2 N and 1134.7 N when the shearer reaches the end of the working face. …”

Technical parameters of the shearer. by Bo Xie (669374)

“…The results indicate that during the bending process of ordinary and reinforced cables in the cable drag system, the tensile force between the cable clamps increases from approximately 28 N and 37 N to a maximum value of 133 N and 146 N, respectively, before decreasing to around 57 N and 66 N. At the connection point between the drag system and the shearer, the tensile force between the cable clamps fluctuates and increases, reaching a maximum value of 925.2 N and 1134.7 N when the shearer reaches the end of the working face. …”

Simulation-related parameters. by Bo Xie (669374)

“…The results indicate that during the bending process of ordinary and reinforced cables in the cable drag system, the tensile force between the cable clamps increases from approximately 28 N and 37 N to a maximum value of 133 N and 146 N, respectively, before decreasing to around 57 N and 66 N. At the connection point between the drag system and the shearer, the tensile force between the cable clamps fluctuates and increases, reaching a maximum value of 925.2 N and 1134.7 N when the shearer reaches the end of the working face. …”

Chain drive specification parameters. by Bo Xie (669374)

“…The results indicate that during the bending process of ordinary and reinforced cables in the cable drag system, the tensile force between the cable clamps increases from approximately 28 N and 37 N to a maximum value of 133 N and 146 N, respectively, before decreasing to around 57 N and 66 N. At the connection point between the drag system and the shearer, the tensile force between the cable clamps fluctuates and increases, reaching a maximum value of 925.2 N and 1134.7 N when the shearer reaches the end of the working face. …”

Femoral tensile test data. by Bo Xie (669374)

“…The results indicate that during the bending process of ordinary and reinforced cables in the cable drag system, the tensile force between the cable clamps increases from approximately 28 N and 37 N to a maximum value of 133 N and 146 N, respectively, before decreasing to around 57 N and 66 N. At the connection point between the drag system and the shearer, the tensile force between the cable clamps fluctuates and increases, reaching a maximum value of 925.2 N and 1134.7 N when the shearer reaches the end of the working face. …”

Matrix Properties by Raman Spectroscopy in femoral bones. by Mishaela R. Rubin (2637448)

Response rate of patients with <i>CYP3A4</i> and <i>CYP3A5</i> polymorphisms after tacrolimus initiation. by Maizumi Furuse (10688237)

“…<p>Panel A shows the response rate of patients with <i>CYP3A4</i> polymorphisms at 1, 2, and 4 weeks after Tac treatment, and panel B shows that of patients with <i>CYP3A5</i> polymorphisms. Clinical response was defined as a partial Mayo score reduction of ≥2 points accompanied by a decrease of at least 30% from baseline and a decrease in the rectal bleeding subscore of ≥1 or an absolute rectal bleeding subscore of 0 or 1. …”

Proportional symbol map of arsenic (As) in micrograms per liter (μg/L) in Bangladesh’s drinking well water. by Seth H. Frisbie (7821866)

S2 Fig - by Linda Karoline Dämmer (16839021)

Torque response of DNA loaded with (H3.3-H4)₂ tetrasomes. by Rifka Vlijm (133750)

The differences between WKY and SHR responses to betaine. by Izabella Mogilnicka (13965422)

Image_1_Novel Action Targets of Natural Product Gliotoxin in Photosynthetic Apparatus.tif by Yanjing Guo (720645)

“…GT decreases the rate of oxygen evolution of PSII with an I₅₀ value of 60 µM. …”

Image_1_Novel Action Targets of Natural Product Gliotoxin in Photosynthetic Apparatus.tif by Yanjing Guo (720645)

“…GT decreases the rate of oxygen evolution of PSII with an I₅₀ value of 60 µM. …”

Changes in GF sound responses with age. by Jonathan M. Blagburn (8259648)

“…(C) Because the antennal sound sensitivity changes but the synapse strength remains constant, there is a corresponding decrease in sound sensitivity of the GF between 10 d and 30–50 d. …”

Effects of drug treatments on culture cells and embryos. by Xiaowen Jiang (8291814)

Linear trajectories of IL-6. by Lucio Manenti (4503532)

PIK3C3 is required for efficient cell-to-cell spread <i>in vivo.</i> by Steven J. Rolland (21376879)

Fig 3 - by Lucio Manenti (4503532)