Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Data_Sheet_1_Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model.pdf by Paige Baldwin (6688517)

“…Dose response analysis indicated that the murine cell lines with conditional BRCA1/2, PTEN, and TP53 deletions had the lowest IC50s. NanoTalazoparib administered on a schedule of three doses weekly slowed disease progression and resulted in significantly less mice with ascites at the end point compared to controls. …”

Superposition of conserved PARG1 C1-RhoGAP domains bound to RhoA protein. by Zen Kouchi (14898435)

<i>mMgat2</i> and <i>HuMgat2</i> mice become obese when fed a HFD. by J. Jose Corbalan (22439198)

Impact of age on sharing of top 5000 TCRβ clones. by Sarah A. Johnson (11355817)

The dose-response curve evolves in time differently for IB and NC models. by Federico Sevlever (8934533)

Serum cholesterol concentrations in hyperthyroid cats and euthyroid controls. by Molly A. Bechtold (18794251)

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency by Caiping Zhang (6745976)

Time-to-death approach to reveal chronic and cumulative toxicity of a fungicide for honeybees not revealed with the standard ten-day test. by Gilles San Martin (3552875)

“…We found evidence of reinforced toxicity when exposure is prolonged, but with an unusual pattern: no cumulative toxicity is observed until 17–18 days, when a point of inflexion appears that suggests a reduced capacity of bees to deal with the toxicant. …”

A survey to determine effects of human interference on grassland and disturbed area herbaceous plants, vertebrates and invertebrates at York University by Justin Kim (3117231)

“…Data was collected via visual survey using transects (two 30m transects), pan traps, 1mx1m quadrats, sweep nets and point survey techniques. For the first data set we obtained the abundance of native plants, abundance of exotic plants, and total number of flowers via quadrat sampling (n=25) along a 50m transect (east to west in the grassland and the disturbed area). …”

Effect of different nitrate levels on spinach. by Kangning Han (12001445)

“…This study aimed to elucidate the regulatory mechanisms of nitrate stress tolerance in spinach (<i>Spinacia oleracea</i> L.). We studied the effects of exogenous application of 15 (control), 50, 100, 150, 200, and 250 mM NO₃^- on spinach growth, physiology, and photosynthesis. …”

Effects of nano-curcumin on cell cycle and apoptosis in breast cancer cells. by Taraneh Givi (22793530)

Image1_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf by Allyson S. Munneke (14200148)

“…Therefore, serotonin signaling through receptor 5-HT2A is likely recruited to promote motivation for protein intake, and chronic reduction of protein-drive through loss of 5-HT2A signaling leads to a lower protein set-point adaptation, which influences physiology, decreases feeding, and increases lifespan. …”

Image2_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf by Allyson S. Munneke (14200148)

“…Therefore, serotonin signaling through receptor 5-HT2A is likely recruited to promote motivation for protein intake, and chronic reduction of protein-drive through loss of 5-HT2A signaling leads to a lower protein set-point adaptation, which influences physiology, decreases feeding, and increases lifespan. …”

Image3_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf by Allyson S. Munneke (14200148)

“…Therefore, serotonin signaling through receptor 5-HT2A is likely recruited to promote motivation for protein intake, and chronic reduction of protein-drive through loss of 5-HT2A signaling leads to a lower protein set-point adaptation, which influences physiology, decreases feeding, and increases lifespan. …”

Result of whole-mount <i>in situ</i> hybridization at 48 hpf. by Yali Ge (417371)

(A, B) Western blot analysis of lysates from the two clones with the TrkB-BAC minigene (77−5 and 77−6) before and after deglycosylation and probed with an antibody recognizing TrkB... by Francesco Tomassoni-Ardori (22216521)

S2 Data - by Christian Hannes (17817132)

“…From January 2019 to January 2022, we conducted a cross-sectional study with four measurement points and, in total, 1,328 participants. …”

S1 Data - by Christian Hannes (17817132)

“…From January 2019 to January 2022, we conducted a cross-sectional study with four measurement points and, in total, 1,328 participants. …”