Substantial Downregulation of Myogenic Transcripts in Skeletal Muscle of Atlantic Cod during the Spawning Period by Kazue Nagasawa (166238)

“…<div><p>Gonadal maturation is an extremely energy consuming process for batch spawners and it is associated with a significant decrease in growth and seasonal deterioration in flesh quality. …”

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resis... by Zhikun Liu (389939)

“…Among them, compound <b>29</b> showed the most potent antitumor activity in vitro with IC₅₀ values at the nanomolar level against the tested tumor cell lines and 1000-fold higher than cisplatin against the multidrug resistant cells (A549/CDDP, A549/DOX, and SKOV-3/CDDP cells), while it showed only moderate cytotoxicity against normal cells (HEUVC cells). …”

Tuning Magnetic and Structural Transitions through Valence Electron Concentration in the Giant Magnetocaloric Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ Phases by Jinlei Yao (1712740)

“…A decrease in the valence electron concentration achieved through the substitution of Eu²⁺ for Gd³⁺ leads to the formation of the interslab Ge–Ge dimers, phase transitions to the Gd₅Si₂Ge₂- and Gd₅Si₄-type structures, and a ferromagnetic ordering in the Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ system. …”

Change from baseline (t = 0) in the concentrations of biomarkers—intestinal fatty acid-binding protein (IFABP), syndecan-1, lipopolysaccharide-binding protein (LBP), soluble CD14 (... by Tamara Mogilevski (14239682)

Loss of capsule significantly reduces <i>N</i>. <i>musculi</i> bacterial burden in the mouse oral cavity but not the gut during persistent colonization. by Katherine A. Rhodes (12557806)

“…<p>A/J mice were orally inoculated with either Wt, Δ<i>228cps</i> or complemented strains (n = 5 per group). …”

The mean scores of epidermis and dermis healing processes in burned rats after 10 and 21 days treatment with silver sulfadiazine 1% (silver), opium 0.05% (OP 0.05%), opium 0.5% (OP... by Omid Mehrpour (9385929)

DataSheet1_Zebrafish EEG predicts the efficacy of antiepileptic drugs.pdf by Jun-Nyeong Shin (14234054)

“…We propose a novel method for pharmacological evaluation of AEDs based on EEG from adult zebrafish, which allows researchers to select more clinically valuable drugs at the early stage of AED screening.…”

Contrast modulates the cone frequency response—sum of sinusoids (SoS) stimuli. by Marcus H. C. Howlett (3921143)

Dispersion rate of antlion larvae on the three substrates Paper (N = 22), Shallow sand (N = 8), Deep sand (N = 8). by Nigel R. Franks (7579916)

Data_Sheet_1_SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer.docx by Maxim L. Bychkov (11429455)

“…Here, using multiplex immunoassay, we demonstrated a decrease in PTEN and mammalian target of rapamycin (mTOR) kinase phosphorylation in A549 cells upon the rSLURP-1 treatment pointing on down-regulation of the PI3K/AKT/mTOR signaling pathway. …”

UV-lamp phototron survivorship. by Nicole L. Berry (9471070)

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

5-HT supplementation induces mitochondrial damage. by Li Gao (131516)

Analysis of the Relationships between DNA Double-Strand Breaks, Synaptonemal Complex and Crossovers Using the <i>Atfas1-4</i> Mutant by Javier Varas (765311)

“…<i>Atfas1-4</i> mutants have reduced fertility due to a decrease in the number of cells that enter meiosis. …”

Histological scoring system of burned dermis. by Omid Mehrpour (9385929)

“…The body weight in Opium 5% significantly decreased compared to all other groups after ten days. …”

Histological scoring system of burned epidermis. by Omid Mehrpour (9385929)

“…The body weight in Opium 5% significantly decreased compared to all other groups after ten days. …”