Image_3_Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan.tif by Fu-Hsiung Su (301644)

“…The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70.…”

Image_2_Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan.tif by Fu-Hsiung Su (301644)

“…The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70.…”

DataSheet1_Trends in the Link Between Perceived Social Support and Life Satisfaction in Adolescents (2013/14–2021/22): A Cross-National Study.docx by Romain Brisson (11604845)

“…The examined sample covered 44 countries and regions (n = 716,083; M_AGE = 13.6; SD_AGE = 1.64; 50.7% female).</p>Results<p>The level of all sources of perceived social support slightly decreased over the examined period (all ω² < .01). …”

Data_Sheet_1_The Impact of Low-Level Viraemia on Virological Failure—Results From a Multicenter HIV Antiretroviral Therapy Cohort Study in Yunnan, China.docx by Jing An (74610)

“…Most of the LLV cases experienced single episodes, and the numbers of LLV with two consecutive episodes, two intermittent episodes, more than two consecutive episodes and more than two intermittent episodes were decreased successively. The risk factors associated with virological failure include: intermediate-level (200–399 copies/mL) and high-level (400–999 copies/mL) LLV, single episodes of LLV and two or more than two consecutive episodes of LLV, which may put the subjects at a 1.28–2.26-fold higher risk for virological failure.…”

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors by Doris A. Schuetz (5202461)

“…We discovered that an increased ligand desolvation barrier by introducing polar substituents resulted in a significant <i>k</i>_on decrease. The slowdown was accomplished by introducing polar moieties to those parts of the ligand that point toward a hydrophobic cavity. …”

PI susceptibility and single round infectivity of patient Gag-Protease derived pre-PI therapy and at the time of treatment failure. by Katherine A. Sutherland (797812)

“…<p>Full-length Gag-Protease from pre-PI therapy and failure time-points was amplified or synthesised, and cloned into our Gag-Pol expression vector p8.9NSX+. …”

Image_3_Germinal centers are permissive to subdominant antibody responses.eps by Philippe A. Robert (7350209)

“…Less immunogenic domains reduced the dominance of GC responses to more immunogenic domains, albeit at a later time point.</p>Discussion<p>The simulations suggest that increased vaccine valency may decrease immunodominance of the GC response to strongly immunogenic domains and therefore, act as a potential strategy for the natural induction of broadly neutralizing antibodies in GC reactions.…”

Image_1_Germinal centers are permissive to subdominant antibody responses.eps by Philippe A. Robert (7350209)

“…Less immunogenic domains reduced the dominance of GC responses to more immunogenic domains, albeit at a later time point.</p>Discussion<p>The simulations suggest that increased vaccine valency may decrease immunodominance of the GC response to strongly immunogenic domains and therefore, act as a potential strategy for the natural induction of broadly neutralizing antibodies in GC reactions.…”

Image_2_Germinal centers are permissive to subdominant antibody responses.eps by Philippe A. Robert (7350209)

“…Less immunogenic domains reduced the dominance of GC responses to more immunogenic domains, albeit at a later time point.</p>Discussion<p>The simulations suggest that increased vaccine valency may decrease immunodominance of the GC response to strongly immunogenic domains and therefore, act as a potential strategy for the natural induction of broadly neutralizing antibodies in GC reactions.…”

DataSheet_1_Germinal centers are permissive to subdominant antibody responses.xlsx by Philippe A. Robert (7350209)

“…Less immunogenic domains reduced the dominance of GC responses to more immunogenic domains, albeit at a later time point.</p>Discussion<p>The simulations suggest that increased vaccine valency may decrease immunodominance of the GC response to strongly immunogenic domains and therefore, act as a potential strategy for the natural induction of broadly neutralizing antibodies in GC reactions.…”

More than two decades after the introduction of Limnoperna fortunei (Dunker 1857) in La Plata Basin by M. A. Pessotto (4770456)

“…Despite maximum density was found near the introduction point (La Plata River) similar value was also observed 2,000 km north (Paraguay River). …”

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors by Doris A. Schuetz (5202461)

“…We discovered that an increased ligand desolvation barrier by introducing polar substituents resulted in a significant <i>k</i>_on decrease. The slowdown was accomplished by introducing polar moieties to those parts of the ligand that point toward a hydrophobic cavity. …”

Table_1_Germinal centers are permissive to subdominant antibody responses.xlsx by Philippe A. Robert (7350209)

“…Less immunogenic domains reduced the dominance of GC responses to more immunogenic domains, albeit at a later time point.</p>Discussion<p>The simulations suggest that increased vaccine valency may decrease immunodominance of the GC response to strongly immunogenic domains and therefore, act as a potential strategy for the natural induction of broadly neutralizing antibodies in GC reactions.…”

Data_Sheet_1_The higher levels of self-reported satisfaction, the lower risk of depressive symptoms: Evidence from a nationwide cross-sectional study in China.docx by Zhiping Niu (9718648)

“…Depressive status was evaluated using the 10-item center for epidemiological studies depression scale (CESD-10), and self-reported life, health, marital status, parent-child relationship, and air quality satisfaction were adopted using Likert 5-point evaluation methods. A generalized linear model (GLM) was applied to explore the association between satisfaction and depression risk.…”

The enhanced radiosensitization of certain cell cultures with combination of 17AAG with inhibitors of the Hsp70 induction. by Vladimir A. Kudryavtsev (3836524)

“…The similarly enhanced radiosensitization was also found in other cell cultures (A549, HT 1080 and Myc-CaP) with 50–200 nM geldanamycin or 30–100 nM radicicol, or 50–200 nM NVP-AUY922 instead of 17AAG and with 100–200 μM KNK437, or 5–20 μM NZ28 instead of quercetin and triptolide (see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173640#pone.0173640.t002" target="_blank">Table 2</a>). …”

Combined M002 and irradiation to neuroblastoma xenografts. by Lauren A. Gillory (469462)

“…Tumor volumes were measured twice weekly and reported as fold change in tumor volume ± standard error. There was a significant decrease in tumor volume in the animals treated with combined modalities for both tumor types (<b>A</b> and <b>C</b>). …”

DataSheet1_Injectable hydrogel with immobilized BMP-2 mimetic peptide for local bone regeneration.pdf by Kirstene A. Gultian (13136634)

Vector genomes and GFP mRNA in heart and liver. by Bryan A. Piras (314201)

“…The shGFP group showed a 77% reduction in cardiac GFP mRNA compared to the shControl group (n=7/group, p<0.0001), and while the shGFP group showed a 39% decrease in mRNA in liver, the difference was not statistically significant (n=7/group, p=0.38).…”

Determination of the changes in contact area during osmotic stimulation of adhered primary hepatocytes. by Tabea A. Mundinger (124217)

“…The original relative contact area (i) changes considerably during hypoosmotic stimulation (ii) and does not return to its original area afterwards (iii). A rapid decrease in relative contact area can be observed after returning to normoosmotic media (iv) followed by the stabilization of the relative contact area (v). b) All areas defined as relative contact areas in the consensus of both wavelengths are represented here as black areas. …”

AXL overexpression dampens the response to IFNα. by Scott A. Read (788751)

“…<p>Stable transfection of Huh-7 cells with PCMV6-AXL was confirmed by western blot, using antibodies against AXL or the fusion Myc tag (A). Huh-7 cells overexpressing AXL induced a stronger but more transient phosphorylation of STAT1 (B), with increased phosphorylation at 15 and 30 minutes post-IFN (50 u/ml), but a strong decrease at 1 h (2 replicates). …”