Data_Sheet_1_Uric Acid Predicts Recovery of Left Ventricular Function and Adverse Events in Heart Failure With Reduced Ejection Fraction: Potential Mechanistic Insight From Network... by Xiqiang Wang (5955647)

“…Background and Aims<p>Heart failure with reduced ejection fraction (HFrEF) still carries a high risk for a sustained decrease in left ventricular ejection fraction (LVEF) even with the optimal medical therapy. …”

Image_1_Piver Type II vs. Type III Hysterectomy in the Treatment of Early-Stage Cervical Cancer: Midterm Follow-up Results of a Randomized Controlled Trial.JPEG by Hengzi Sun (6017819)

“…<p>Introduction: With the expansion of value-based medicine, we explore whether using type III hysterectomy to treat low-risk, early-stage cervical cancer constitutes overtreatment. …”

Image_1_Uric Acid Predicts Recovery of Left Ventricular Function and Adverse Events in Heart Failure With Reduced Ejection Fraction: Potential Mechanistic Insight From Network Anal... by Xiqiang Wang (5955647)

“…Background and Aims<p>Heart failure with reduced ejection fraction (HFrEF) still carries a high risk for a sustained decrease in left ventricular ejection fraction (LVEF) even with the optimal medical therapy. …”

Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms by Max Norman Tandrup Lambert (4093156)

“…Effective treatments against VMS with minimal cancer risks are needed. We investigate the effects of a highly bioavailable aglycone rich Red Clover isoflavone treatment to alleviate existing menopausal VMS, assessed for the first time by 24hour ambulatory skin conductance (SC)</p><p>Methods and results</p><p>We conducted a parallel, double blind, randomised control trial of 62 peri-menopausal women aged 40–65, reporting ≥ 5 hot flushes/day and follicle stimulating hormone ≥35 IU/L. …”

Image_1_Indole-3-carboxyaldehyde does not reverse the intestinal effects of fiber-free diet in mice.pdf by Mark M. Smits (9242563)

“…GLP-1 secretion from GLUTag cells was unchanged after five minutes of exposure to I3A. However, GLP-1 levels increased after 120 minutes of exposure to 1 mM (60% increase, p=0.016) and 5 mM (89% increase, p=0.0025) I3A. …”

Image_3_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.JPEG by Yamina El Hamdaoui (6759080)

“…Interestingly, in the case of the α7 nAChR, but not the α3β2 subtype, the loss of potency could be rescued by an R5D substitution. In conclusion, we demonstrate efficient expression of functional but alternatively folded ribbon TxIA variants in E. coli and provide the first structure–function analysis for a ribbon 4/7-α-conotoxin at α7 and α3β2 nAChRs. …”

Image_3_Photosynthetic Carbon Fixation and Sucrose Metabolism Supplemented by Weighted Gene Co-expression Network Analysis in Response to Water Stress in Rice With Overlapping Grow... by Xinpeng Wang (4611307)

“…The results showed that short-term drought stress promoted photosynthetic carbon fixation. However, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) activity significantly decreased, resulting in a significant decrease in photosynthetic rate. …”

Pulmonary and Cardiac Function in Asymptomatic Obese Subjects and Changes following a Structured Weight Reduction Program: A Prospective Observational Study by Matthias Held (631393)

“…</p><p>Results</p><p>74 subjects (32 male, 42 female; mean age 42±12 years) with an average BMI 42.5±7.9, body weight 123.7±24.9 kg were enrolled. …”

Summary of the effects of deletion of Y2 receptors on non-NPY-ergic or NPY-ergic neurons in the brain. by Yan-Chuan Shi (153820)

“…However, Y2 receptors on NPY-ergic neurons in the amygdala induce anxiogenic effects <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011361#pone.0011361-Tasan1" target="_blank">[50]</a>, likely due to decreased endogenous NPY-ergic action <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011361#pone.0011361-Heilig1" target="_blank">[56]</a>. …”

Thyroid hormone (T₃) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy by Winifred W. Yau (5744939)

“…We next generated an <i>Atg5</i> conditional knockout mouse model (<i>Atg5</i> cKO) by injecting <i>Ucp1</i> promoter-driven <i>Cre</i>-expressing adenovirus into <i>Atg5</i>^Flox/Flox mice to examine effects of BAT-specific autophagy on thermogenesis <i>in vivo</i>. …”

Image_4_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Image_2_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Image_7_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Image_8_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Image_1_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Image_9_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Data_Sheet_1_Large Pelagic Fish Are Most Sensitive to Climate Change Despite Pelagification of Ocean Food Webs.PDF by Colleen M. Petrik (9693980)

“…When integrated globally, the biomass and production of all types of fish decreased under a high emissions scenario (RCP 8.5) compared to mean contemporary conditions. …”

Image_6_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Image_3_Right Ventricular Diastolic Performance in Patients With Chronic Thromboembolic Pulmonary Hypertension Assessed by Echocardiography.JPEG by Hong Meng (82691)

“…Of the 71 patients, 52 (73%) had decreased RV systolic function; 12 (16.9%), 26 (36.6%), and 33 (46.5%) patients had normal RV diastolic pattern, abnormal relaxation (stage 1), and pseudo-normal patterns (stage 2), respectively. …”

Lysosomal translocation of GAPDH-HT reflects CMA activity in HeLa cells. by Takahiro Seki (185432)

“…We counted the number of GAPDH-HT dot-positive cells in 50–70 GAPDH-HT-expressing cells. …”