Table_1_Effect of red meat, vegetable, tobacco, and alcohol consumption on national cancer mortality index: Data from 1989 to 2013 in 37 developed countries.XLSX by Myung-Bae Park (6842147)

“…A similar trend was also observed in the 3 and 5-year lagged models. RM consumption also demonstrated a significantly positive association with the incidence of colon cancer in the OLS. …”

Table_1_Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.XLSX by Lisa J. Martin (228675)

“…The LP/HC diet group also showed reduced birth and weanling weights, whereas the HP/LC offspring displayed increased weanling weight with increased adiposity beyond 5 months of age. Gene expression profiling of hypothalamus and liver revealed alterations in diverse molecular pathways by both diets. …”

Table1_Integrative transcriptomic analysis reveals the molecular responses of tobacco to magnesium deficiency.xlsx by Tingmin Liang (7818773)

“…</p>Methods<p>In this study, we conducted a comprehensive transcriptome analysis on tobacco (Nicotiana tabacum L.) seedling leaves to investigate changes in gene expression in response to different levels of Mg supply, including Mg-deficient, 1/4-normal Mg, normal Mg, and 4×-normal Mg, with a particular focus on Mg deficiency at 5, 15 and 25 days after treatment (DAT), respectively.…”

Data_Sheet_1_Genome-Wide CRISPR/Cas9 Screen Identifies New Genes Critical for Defense Against Oxidant Stress in Toxoplasma gondii.xlsx by Yun Chen (279569)

“…In addition, several previously uncharacterized genes were identified, among which five hypothetical protein-coding genes, namely, HP1–HP5, were selected for further functional characterization. …”

Identification of polymorphisms in Gag that significantly affect RC, several of which can be linked to HLA-class I alleles. by Jessica L. Prince (117343)

“…<p>(A) In a pair-wise analysis of all amino acids represented in the 149 <i>gag</i> sequences tested, we observed 49 amino acids at 31 unique positions that were statistically associated (p<0.05) with changes in RC (open circles RC decreasing, filled circles RC increasing), 3 of which were significant at (q<0.2) when adjusted for multiple comparisons (red for RC reducing and green for RC increasing). …”

Table1_The impact of high nicotine concentrations on the viability and cardiac differentiation of mesenchymal stromal cells: a barrier to regenerative therapy for smokers.xlsx by Maryam Gheisari (18306652)

“…Cells were treated with 5-azacytidine (an inducer of cardiac differentiation), and then the expressions of cardiac-specific markers were calculated by qPCR.…”

FA_<i>x</i>Cs_1–<i>x</i>PbI₃ Nanocrystals: Tuning Crystal Symmetry by A‑Site Cation Composition by Julian A. Vigil (1768927)

“…All compositions crystallize in the perovskite structure; however, the average structure lowers in symmetry from the α (cubic) to β (tetragonal) to γ (orthorhombic) perovskite phases with decreasing <i>x</i> (Cs addition). The corresponding α- to β- and β- to γ-phase transitions occur between <i>x</i> = 0.75–0.5 and <i>x</i> = 0.25–0.1, respectively. …”

Image_3_Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.tif by Evan Craig (4025492)

“…It is, therefore, imperative that more effective drug formulations with decreased toxicity profiles are developed. Previous studies had shown that 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide (also called Retro-2) has efficacy against Leishmania infections. …”

Image_1_D-Serine Contributes to Seizure Development via ERK Signaling.tif by Tie Ma (6505097)

“…L-aspartic acid β-hydroxamate (LaaβH), an inhibitor of SR, significantly prolonged the latencies of seizures, shortened the durations of seizures, and decreased the total EEG power in rats. In contrast, D-amino acid oxidase inhibitor 5-chlorobenzo[d]isoxazol-3-ol (CBIO), which can increase D-serine levels, showed the opposite effects. …”

Image_2_Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy.pdf by Fátima Cano-Cano (10322534)

“…A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effect of (S_S,1R)-1-docecylsulfiny-5N,6O-oxomethylidenenojirimycin ((Ss)-DS-ONJ), a member of the sp²-iminosugar glycolipid (sp²-IGL) family, by decreasing iNOS and inflammasome activation in Bv.2 microglial cells exposed to pro-inflammatory stimuli. …”

DataSheet2_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

Enhancement of NK Cell Cytotoxicity Induced by Long-Term Living in Negatively Charged-Particle Dominant Indoor Air-Conditions by Yasumitsu Nishimura (769836)

“…We reported previously that these conditions induced a slight and significant increase of interleukin-2 during a 2.5-h stay and an increase of NK cell cytotoxicity when examining human subjects after a two-week night stay under these conditions. …”

Table_8_Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.XLSX by Lisa J. Martin (228675)

“…The LP/HC diet group also showed reduced birth and weanling weights, whereas the HP/LC offspring displayed increased weanling weight with increased adiposity beyond 5 months of age. Gene expression profiling of hypothalamus and liver revealed alterations in diverse molecular pathways by both diets. …”

Data_Sheet_1_Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo.pdf by Florian Gabel (8475108)

“…After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human. These active compounds are inactivated by the same UDP-glucuronosyltransferase isoforms as those involved in the metabolism of morphine. …”

Table_2_Plant Community Traits Respond to Grazing Exclusion Duration in Alpine Meadow and Alpine Steppe on the Tibetan Plateau.DOCX by Tianyu Zhan (8719563)

“…The efficiency of vegetation restoration in terms of productivity and diversity gradually decreased with increasing grazing exclusion duration. …”

Metrics Derived from Analysis of DNA from Affected Family Member 7 Using Illumina Infinium HumanHap550 Genotyping Chips by Joyce van de Leemput (271956)

“…Clearly, these plots show a contiguous region ~200 kb long with decreased copy number and apparent homozygosity (bounded by a red box). …”

Image 1_Body Mass Index mediates the associations between dietary approaches to stop hypertension and obstructive sleep apnea among U.S. adults.tiff by Songtao Li (186776)

“…DASH scores had a negative association with the risk of OSA (OR = 0.91, 95%CI: 0.88–0.95, p < 0.01). Next, we divided DASH scores into quintiles groups. In comparison to the reference group Q1, groups Q5 had adjusted OR values of 0.63 (95%CI: 0.52–0.76, p < 0.01). …”

Image2_Seawater temperature drives the diversity of key cyanobacteria (Synechococcus and Prochlorococcus) in a warming sea.tiff by Alexandra Coello-Camba (6489533)

“…Maximum cyanobacteria richness was observed at approximately 27.5°C, declining at higher and lower temperatures (polynomial fit, R² = 0.2, p<0.0001). …”

Table4_Integrative transcriptomic analysis reveals the molecular responses of tobacco to magnesium deficiency.xlsx by Tingmin Liang (7818773)

“…</p>Methods<p>In this study, we conducted a comprehensive transcriptome analysis on tobacco (Nicotiana tabacum L.) seedling leaves to investigate changes in gene expression in response to different levels of Mg supply, including Mg-deficient, 1/4-normal Mg, normal Mg, and 4×-normal Mg, with a particular focus on Mg deficiency at 5, 15 and 25 days after treatment (DAT), respectively.…”

Table 2_Global, regional and national patterns and gender disparity of intraocular foreign bodies from 1990 to 2021.doc by Yi Shan (160293)

“…</p>Results<p>The total all-age prevalence and DALYs due to IOFBs rose by 41.9 and 35.5%, respectively, from 1990 to 2021, and the age-standardized prevalence and DALYs rates decreased by 15.2 and 19.6%. …”