Stem-binding bnAbs prevent membrane fusion in an <i>in vitro</i> single particle fusion assay. by Boerries Brandenburg (32421)

“…Upon lowering the pH from 7.4 to 5.0 (t = 0 seconds), viruses incubated with only 15 nM CR8020 or CR6261 undergo HA-mediated fusion with the target membrane, visualized as a rapid increase in signal due to fluorescence dequenching followed by diffusion of R18 molecules away from the fusion site (<b>B</b> and <b>C</b>, yellow triangles), whereas no fusion events occur when viruses are incubated with 1500 nM bnAbs (<b>D</b> and <b>E</b>). …”

Supporting Information. by Segni B. Ligaba (695899)

“…D, Network analysis of genes (highlighted in blue) whose knockdown decreased HFK growth. Fig. E, Uncropped and unadjusted western blots shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116755#pone.0116755.g004" target="_blank">Fig. 4C</a>. …”

Table_1_Subclinical Hyperthyroidism Could Predict Poor Outcomes in Patients With Acute Ischemic Stroke Treated With Reperfusion Therapy.DOCX by Sang-Hwa Lee (6092549)

“…However, compared with patients in the euthyroid state, patients with subclinical hyperthyroidism had an increased risk of poor functional outcomes at 3 months after a stroke (adjusted odds ratio [OR] 2.50, 95% confidence interval [CI] 1.01–6.14 for a mRS score of 3 to 6) and a decreased rate of successful reperfusion after reperfusion therapy (OR 0.13, 95% CI 0.04–0.43).…”

Hematopoietic lineage analysis of the mice and leukemic mice by Mei-Yi Wu (53957)

“…) Comparison of cell populations in bone marrow and spleen (HSC, CMP, granulocyte, monocyte, erythroid cell, T cell, and B cell) and cell counts in peripheral blood (neutrophil, monocyte, hemoglobin, RBC, lymphocyte, and platelet) between wild-type mice (n = 5), the mice with CMML-like phenotype (n = 5), and the mice with acute myeloid leukemia (AML) (n = 5). …”

Prevalence of overweight and obesity in schoolchildren: relationship with socioeconomic status, gender and age by Edilson Hobold (4098277)

“…The prevalence rates according to different strata (gender, age and socioeconomic status) were compared by means of logistic regression using odds ratios. The prevalence of overweight and obesity was 14.8% and 5.8% among boys, respectively, and 15.2% and 4.5% among girls. …”

High-Throughput Profiling of <i>Caenorhabditis elegans</i> Starvation-Responsive microRNAs by Laura Garcia-Segura (824200)

“…<i>elegans</i> changed their expression under starvation conditions as compared to well-fed worms by means of deep sequencing in early L4 larvae. Our results indicate that 13 miRNAs (miR-34-3p, the family of miR-35-3p to miR-41-3p, miR-39-5p, miR-41-5p, miR-240-5p, miR-246-3p and miR-4813-5p) were upregulated, while 2 miRNAs (let-7-3p and miR-85-5p) were downregulated in 12-hr starved vs. well-fed early L4 larvae. …”

Neuronal cells expressing the cGMP gated cation channel TAX-2/TAX-4 are required to modulate the effect of neuronal stress on fat-remodeling in the intestine. by Laetitia Chauve (8600553)

“…This allele causes a partial rescue (50%) of <i>hsf-1</i>^<i>neuro</i> fat stores. …”

Administration of CORM-2 inhibits diabetic neuropathy but does not reduce dyslipidemia in diabetic mice by Karen Alejandra Méndez-Lara (5819492)

“…The administration of 10 mg/kg CORM-2 during five consecutive days inhibited allodynia and hyperalgesia and significantly ameliorated spinal cord markers (<i>Cybb</i> and <i>Bdkrb1</i>expression) of neuropathic pain in Stz mice, but it did not reduce the combined dyslipidemia shown in Stz-treated mice. …”

Scale-invariance of receptive field properties in primary visual cortex-3 by Tobias Teichert (76469)

Palladin induced SMC marker genes transcription is mediated in part through the CArG elements found within the SM22 and SMA promoters. by Li Jin (40265)

Fig 7 - by Fiona J. Stenning (10987803)

Assays showing functional activity of the aging genes. by Dror Sagi (156783)

“…ATP levels were measured using a luciferase bioluminescent assay. y-axis shows ATP levels (nmoles per mg of protein). * indicates p<0.01, t-test. Error bars are SEM of three independent experiments. …”

Image_1_Weaning Age Affects the Development of the Ruminal Bacterial and Archaeal Community in Hu Lambs During Early Life.JPEG by Huiling Mao (6520772)

“…Compared to W30, PW30 had a decreased relative abundance of Bacteroidetes. …”

Table_1_Weaning Age Affects the Development of the Ruminal Bacterial and Archaeal Community in Hu Lambs During Early Life.DOCX by Huiling Mao (6520772)

“…Compared to W30, PW30 had a decreased relative abundance of Bacteroidetes. …”

TNNI3K expression leads to premature death in the <i>Csq</i> transgenic model of cardiomyopathy. by Ferrin C. Wheeler (259443)

“…Survival is severely decreased for double positive transgenics (<i>TNNI3K^tg</i>/<i>Csq^tg</i>) to an average of 17 days with a range from 15 to 21 days. …”

Abnormal development of neural stem cell-derived neurospheres from <i>Raldh2^−/−</i> spinal cords. by Marie Paschaki (179823)

“…<p>Neurospheres were derived from dorsal cervical/brachial spinal cord from E12.5 WT and <i>Raldh2^−/−</i> embryos. (A,B) After growth of dissociated progenitor cells in suspension, in 6-well plates, for 10 days in a defined selective medium (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032447#s4" target="_blank">Materials and Methods</a>), the number of spheres developing from <i>Raldh2^−/−</i> embryos spinal cords is decreased by 25% compared to WT (E: 11.1±0.88 spheres/well for WT; 8.40±1.50 for mutants; n = 9; T- test: P value = 0,0009). …”

HCV-induced chronic ER stress confers resistance to drug induced UPR. by Emmanuelle Merquiol (204704)

“…Quantification of the results was obtained from densitometric scanning of the blots (means±S.D.) of 3 experiments. * = p<0.05 (ANOVA, one way) for day 5 versus day 14 post infection.…”

Pollen-based Holocene vegetation reconstruction.xlsx by Yuanhao Sun (12697028)

“…In the Daihai basin, the vegetation cover changed relatively little, maintaining values of 45–50%, and only increased during the interval of 8–5.1 ka, when it attained a maximum of 67%. …”

Table1_Anti-hyperglycemic effects of Cissus quadrangularis extract via regulation of gluconeogenesis in type 2 diabetic db/db mice.DOCX by Jeong-Won Kim (18464976)

“…In this study, the therapeutic effects of C. quadrangularis extract (CQR-300) on type 2 diabetes mellitus (T2DM) were investigated in a leptin receptor-mutated db/db mouse model.</p><p>Methods: CQR-300 was orally administered to db/db mice (n = 6/group) at different doses (50, 100, and 200 mg/kg) for 8 weeks. …”

Datasheet1_Diagnostic and prognostic value of an ejection fraction adjusted for myocardial remodeling.docx by Wei Xuan Chan (11949866)

“…Both low EF and low EFa were associated with a high HF readmission risk. However, in the cohort with a normal EF (EF ≥ 50%), models using EFa were significantly more associative with HF readmissions within 3 years, where the leave one out cross validation ROC analysis showed a 18.6% reduction in errors, and Net Classification Index (NRI) analysis showed that risk increment classification of events increased by 12.2%, while risk decrement classification of non-events decreased by 16.6%.…”