Effects of zoledronic acid (ZOL) on SACC-83 in vitro and in vivo. by Xi-Yuan Ge (588495)

“…<p><b>A</b> After ZOL treatment, the total number of live SACC-83 cells was markedly decreased both dose and time dependently. …”

8oxoG and AP lesions disrupt TRF2 recognition of telomeric DNA by Patricia L. Opresko (7493)

“…Substrates (2.5 nM) were incubated alone (−) or together with decreasing concentrations of TRF2 (200, 100, 50 or 25 nM) for 20 min at 4°C in TRF2 binding buffer. …”

Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory-5 by Feng Luo (47640)

“…</p><p>Published online 14 Aug 2007</p><p>PMCID:PMC2212665.</p><p></p> mean of noise is zero and its standard deviation (σ) is set to 1, 2, 5, 10, 20, 30, 40, and 50% of the average of absolute expression value of whole dataset. …”

Bcl-2, Bax, and caspase-3 immunostained sections and morphometric analysis of hepatocytes in the control, PbAc-, IOLE-, and IOLE+PbAc-treated rats. by Ahmed E. Abdel Moneim (3155442)

“…In the IOLE+PbAc group, the number of apoptotic hepatocytes was decreased. (scale bar 50 μm) (B) The plots show an increase in apoptotic hepatocytes in the control, PbAc-, IOLE-, and IOLE+PbAc-treated rats. …”

Effect of replacing beef fat with safflower oil on physicochemical, nutritional and oxidative stability characteristics of wieners by Emel KAYNAKCI (10463779)

“…Incorporation of SO increased CIE L* and b* values, whereas it caused a decrease in CIE a* values of wieners (P < 0.05). …”

Label-free real-time multi-parametric monitoring enables high content analysis. by Heinz-Georg Jahnke (122745)

“…The effect on the APD was determined for one hour after doxorubicin application and revealed a concentration dependent response with an EC₅₀ value of 17 µM (n  = 3 hCMC), (B) The impedance analysis revealed a concentration- and time-dependent decrease where IC₅₀ values could be determined for each time point (n  = 5 hCMC). …”

DataSheet1_Attenuating coherent environmental noise in seismic data via the U-net method.pdf by Yu-Tai Wu (14584727)

Accessibility of IpaC residues from the extracellular surface is altered by the interaction of IpaC with intermediate filaments. by Brian C. Russo (7866425)

Supplementary Material for: First-in-human effects of PPT1 inhibition using the oral treatment with GNS561/ Ezurpimtrostat in patients with primary and secondary liver cancers by Harding J.J. (12088145)

“…Liver trough concentrations were much higher than in plasma a median time of 28 days of administration with a mean liver to plasma ratio of 9559 (Min 149-Max 25759), which is in accordance with rat preclinical data observed after repeated administration. …”

Interaction between the N-terminus of both caspase 8 and SPARC are required to reduce cell viability and enhance apoptosis. by Mahbuba Rahman (198499)

“…<p><b>A–B</b>) Cell viability further decreased in MIP/SP and MIP/SP-N after transfection with wild-type caspase 8 and 5-FU treatment, relative to empty vector (EV, control): MIP/SP: 77.2±3.8 (EV) vs. 59.1±1.5% (caspase 8) (p<0.005); MIP/SP-N: 68.8±4.8 (EV) vs. 50.6±3.6% (caspase 8) (p = 0.04). …”

Changes in the immunological index after <i>Salacia reticulata</i> extract (SRE) ingestion. by Yuriko Oda (832789)

“…<p>(<b>a</b>) Changes in the T-cell proliferation index from the initial values to the values after 4 weeks are shown in the plot. …”

Kinases are recruited to the signaling complex by alternative N-t localization domains. by Paloma M. Sato (672126)

“…In most cases, mutations that disrupt specific recruitment interactions decrease pathway activation between 40%–50%. MUT Ste20[N]-Ste50[C] might still localize to the signaling complex, as Ste50's RA domain binds Cdc42 independently of Ste20's PBD domain <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002012#pbio.1002012-Truckses1" target="_blank">[53]</a>. …”

Effect of SARS-CoV-2 Infection and Infection Severity on Longer-Term Glycemic Control and Weight in People With Type 2 Diabetes by Rachel Wong (5544899)

Response gain control by ACh. by Shogo Soma (429657)

“…Gray circles indicate facilitated and suppressed cells whose C₅₀ were decreased or increased by more than 1 SD from the population average, respectively (C, facilitated cells, <i>n</i> = 4; D, suppressed cells, <i>n</i> = 7). …”

Effect of NK depletion on IFN-γ production in tripartite cultures. by Loke Tim Khaw (433343)

Effect of endothelial cells on cytokine production in PBMC/iRBC co-cultures. by Loke Tim Khaw (433343)

Tau overload causes behavioral deficits and maintains neurodegeneration at older ages. by Kaushik Ghosal (244754)

“…<p>A. hTau animals also showed decreased working memory as measured by deficits in spontaneous alternations compared to age-matched wild-type animals. …”

Data_Sheet_1_Immediate and long-term electrophysiological biomarkers of antidepressant-like behavioral effects after subanesthetic ketamine and medial prefrontal cortex deep brain... by Matthew Bergosh (18854590)

“…</p>Results<p>We found that the depression-like behavioral and weight effects of CORT correlated with a decrease in aperiodic-adjusted theta power (5–10 Hz) and an increase in sample entropy during the administration phase, and an increase in theta peak frequency and a decrease in the aperiodic exponent once the depression-like phenotype had been induced. …”

Weight gain was associated with worsening glycemia and cardiovascular and kidney outcomes in type 2 diabetes patients independent of diabetes medication in the GRADE Randomized Con... by Deborah J. Wexler (492527)

MEKi inhibits growth and ablates MAPK regardless of <i>PIK3CA</i>^<i>mut</i> status. by Robert S. McNeill (5485064)

“…<p>Selumetinib IC₅₀ were similar regardless of <i>PIK3CA</i>^<i>mut</i> status in NHA (<b>A</b>), but slightly higher in most <i>PIK3CA</i>^<i>mut</i> NHA^RAS compared to parental cells (*, P≤0.03) (<b>B</b>) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200014#pone.0200014.s011" target="_blank">S11 Fig</a></b>). …”