First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

JBPOS0101 decreased Amyloid Beta (Aβ) aggregates in the cortex and hippocampal regions in 5xFAD mouse brains. حسب Jihoon Jeong (4852690)

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China حسب Yating Ning (11264310)

Image_1_Reduced Ca2+ transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway.PDF حسب Arunima Debnath (13136676)

"…Therefore, even within a single neuron, somal Ca²⁺ signal reduction may indicate either increased or decreased depolarization amplitude, depending on which neuromodulatory signaling pathways are activated, underscoring the need for careful interpretation of Ca²⁺ imaging data in neuromodulatory studies.…"

<i>eIF2A</i> overexpression decreases the cell wall protein levels. حسب Laura Meyer (4033793)

الموضوعات:

ngLVA degradation kinetics. حسب Nicole A. Grieshaber (11175417)

"…<p>Cos-7 cell infected with L2-euoprom-ngLVA, treated with 34 μg/ml chloramphenicol (CAM) or vehicle only (1:1000 EtOH in RPMI) at 35 hpi (arrow). …"

TBEV-induced translational arrest results in the decreased protein levels of GAPDH, HPRT1, and viperin. حسب Martin Selinger (3195987)

Silencing of RCC1L isoforms alter the levels of mitochondrial ribosomal proteins and biogenesis factors resulting in decreased mitochondrial translation. حسب Aurelio Reyes (412135)

Can inoculation with diazotrophic bacteria decrease the productivity loss of defoliated Vigna unguiculata (L.) Walp? حسب Caliane da S. Braulio (10469226)

Small RNR subunit interaction with Ydj1 is decreased in Ssa3 and Ssa4 cells. حسب Laura E. Knighton (5991239)

ROC curve and P-R curve (attack traffic proportion = 50%). حسب Longyan Ran (18452261)

Abolishing the ordered neuron density gradient decreased the positive correlation observed for axon elongation scaling. حسب Sarah F. Beul (6008801)

Untargeted metabolomic analysis of delayed death-parasites indicates isoprenoid defect and decreased haemoglobin turnover. حسب Kit Kennedy (4915510)

Assessment of exoprotein concentration in a 50-mL culture of MH96. حسب Marion Schoof (11999106)

STAT6-driven immunity decreases <i>N</i>. <i>brasiliensis</i> reproductive output and survival within host. حسب Annabel A. Ferguson (17616286)

Trial profile. حسب Chanel Avenant (409756)

"…Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …"

E₅₀ values of angle. حسب Junxia Zhou (14381598)

"…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …"

Curve fitting of E₅₀. حسب Junxia Zhou (14381598)

"…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …"

Fitting curves of E₅₀. حسب Junxia Zhou (14381598)

"…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …"