Lifespan data. by Brian Onken (86790)

Increased Locomotory Healthspan and Survival with <i>pck-2</i> Overexpression, as Well as Expression of <i>pck-2</i> in the Intestine, Require <i>daf-16</i>. by Brian Onken (86790)

Excess glucose availability negatively impacts healthspan of young and old animals; conversely, the benefits of disrupting glycolysis do not include extended maximal lifespan. by Brian Onken (86790)

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…Trials with 5 and 13 day old animals also showed impaired older age locomotion in 4% glucose (Supplemental <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.s002" target="_blank">S1A and S1B Fig</a>). …”

Gluconeogenic gene <i>fbp-1</i> expression is required for healthspan extension under dietary restriction. by Brian Onken (86790)

Dietary Restriction Induces Gluconeogenic Gene <i>pck-2</i> Expression via DAF-16, and <i>pck-2</i> Expression is Needed for DR-associated Healthspan Benefits. by Brian Onken (86790)

“…Elevated gluconeogenic activity (dependent on DAF-16-promoted PCK-2 expression) acts in a feed-forward capacity to further enhance the gluoconeogenic pathway and may inhibit glycolysis/insulin signaling to promote/maintain DAF-16 signaling and healthy metabolism (inhibition represented by a dashed line).…”

The healthspan effects of glycolytic and gluconeogenic disruptions are absent in the <i>age-1</i> insulin signaling mutant background. by Brian Onken (86790)

The GON domain expression alters dauer formation and longevity. by Sawako Yoshina (375229)

Spatial training decreases endogenous PTEN ubiquitination and <i>Pten</i> cKO mice show impaired spatial learning and memory. by Wei-Lun Hsu (1756123)

“…The <i>Pten</i> cKO mice showed impaired retention performance and made less travelling in the target quadrant than the <i>Pten loxp</i> mice. <b>(G)</b> The PTEN expression level is decreased in the <i>Pten</i> cKO mice than the <i>Pten loxp</i> mice (t_1,16 = 17.96, <i>p</i> < 0.001). …”

Knocking down <i>enok</i> without affecting <i>rhi</i> levels decreased transcript levels from 42AB. by Shih-Ying Tsai (3576587)

Three weeks of high-fat feeding compared to rats on CHOW decreased whole-body insulin sensitivity as assessed by hyperinsulinemic eulgycemic clamp. by Silvie Timmers (357546)

Supplementary Material for: Decreased Toll-Like Receptor 2 and Toll-Like Receptor 7/8-Induced Cytokines in Parkinson's Disease Patients by da Silva D.J. (4159168)

“…The association between a decreased TLR response in periphery and damage of brain in PD must be further investigated.…”

Fig 3 - by Sumei Luo (9570740)

Simulated ground-level light distribution – enhanced uniformity under RSSCA design (a) In crop-growing area under RSSCA systems, and (b) Conventional PV system. by Ngoc-Hai Vu (22290844)

DataSheet1_Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normaliz... by Vanessa B. Candido (14670266)

Decreased mRNA expression of thin and thick filament associated genes in the lack of RYBP during <i>in vitro</i> cardiac differentiation. by Surya Henry (9132175)

Supporting data: Kittiwake conductivity data from Increased summer food supply decreases non-breeding movement in black-legged kittiwakes by Shannon Whelan (8127795)

Supporting data: Kittiwake location data from Increased summer food supply decreases non-breeding movement in black-legged kittiwakes by Shannon Whelan (8127795)

CXCR3 expression on leukocytes in MPN subtypes showing decreasing levels of CXCR3 on monocytes over the MPN biological continuum in monocytes. by Charlotte Liisborg (7253708)

Bradykinin stimulation of PS-1 (M146L) AD fibroblasts results in decreased p38 activation relative to control fibroblasts. by Graziella Mendonsa (374346)