Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment-3 by Iliya Lefterov (73826)

“…</p><p></p>r vehicle for 18 h prior to LPS treatment (50 ng/ml). Control cells received vehicle only (veh). …”

Reduced synaptic density in hippocampal neurons grown on top of DS astrocytes can be reversed by treatment with TSP-1. by Octavio Garcia (236402)

“…<b>B</b>) Synaptic density was expressed as the number of colocalized puncta per 50 µm of dendrite in NL, DS and DS treated with 250 ng/ml TSP-1 cocultures. …”

VCE-003 reduces the expression of inflammatory marker mRNAs in the spinal cord and of iNOS protein in BV2 cells. by Francisco J. Carrillo-Salinas (551055)

“…Proteins in lysates (30 µg) from BV2 cells stimulated with LPS (50 ng/ml) and IFNγ (100 u/ml), and pre-treated with VCE-003 (1 µM). …”

Reduction of plasma membrane PtdIns(4)<i>P</i> and PtdIns(4,5)<i>P</i>₂ levels and their effect on the Ins<i>P</i>₃ and Ca²⁺ signals upon hormonal... by Gergő Gulyás (733813)

“…(E and F) HEK 293T cells were transiently transfected with AT1R-Δ319 together with the indicated BRET sensors. A 10-minute preincubation with 10 μM wortmannin or 10 nM A1 was used to decrease the PtdIns(4)<i>P</i> level of the PM. …”

CDA deficiency leads to excess dCTP, inhibiting PARP-1 activity and leading to UFB formation. by Simon Gemble (168663)

“…(G) (1) CDA deficiency leads to intracellular dCTP accumulation, decreasing basal PARP-1 activity. (2) The decrease in basal PARP-1 activity leads to an increase in unreplicated DNA sequences (preferentially at centromeres and CFS sites). (3) During late G2/early mitosis, some of this unreplicated DNA is probably processed by MUS81-EME1 and ERCC1 nucleases as previously suggested [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref036" target="_blank">36</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref012" target="_blank">12</a>], leading to DNA synthesis during metaphase (EdU foci) and preventing supernumerary UFB formation. (4) Some of the excess unreplicated DNA sequences are not processed by the nucleases, leading to supernumerary UFB formation.…”

Beta power timecourses time-locked to the response (button press at time zero), expressed as percent change from baseline in the SMOT areas. by Lauren E. Beaton (4763232)

“…After the switch and immediately preceding the response (highlighted in dark blue color), the primed hemisphere rebounds back to baseline while the responding hemisphere continues to decrease. In the right panel, lateralized beta power is presented in the bar graphs as a subtraction of beta power in the contralateral—ipsilateral SMOT in the early (-300 to -200 ms) vs late (-100 to 0 ms) time windows.…”

Table 1_Trends in the disease burden of maternal sepsis and other maternal infections attributable to iron deficiency from 1990 to 2021 and its projection until 2050.docx by Chunfeng Zhu (327990)

“…The ASMR and age-standardized DALY rate of MSMIs attributable to iron deficiency were negatively correlated with SDI. Projections indicated a continued decrease in the burden of MSMIs attributable to iron deficiency by 2050.…”

Evidence for constitutive activation of cytoprotective enzymes network in vitiligo melanocyte cultures. by Barbara Bellei (177809)

“…Values reported as O.D. decrease over untreated control represent the means ± SD of experiments performed in triplicate. …”

Lack of oligodendrocytes after DTA-mediated ablation of <i>C1ql1</i>-expressing OPCs. by Shayan Moghimyfiroozabad (19066182)

“…Higher magnification of the coronal sections in the center and lateral parts of CC and cortex shows the dramatic reduction in the density of OLs (CC1^pos GFP^pos cells, yellow arrowhead) in <i>C1ql1</i>^<i>Cre</i><i>; Sox10</i>^<i>DTA</i> mice at P16. Scale bars = 100 μm. Quantification shows a massive decrease in OL density in the <i>C1ql1</i>^<i>pos</i> OPC-ablated brains. …”

The involvement of trimolecular complex components in the process of tumor cell transendothelial migration. by Evelyn B. Voura (475793)

“…Increasing concentrations were 50, 100 and 200 mM. Error bars=mean±S.E.M. (F) Lamellipodia from MDA-MB231 (upper panels) and WM239 (lower panels) express furin in 1 μm confocal sections when cultured alone on Matrigel. …”

Relative activities of oxidizing enzymes in activated sludge during the stable stage. by Cong Jiang (3175146)

“…The relative activity is less 100% indicating a decrease of enzyme activity (compared to the control). asterisks (*) indicating the statistical difference from the control (<i>p</i> < 0.05).…”

Effect of pulse electrical field on tumor absolute impedance. by Yossi Mandel (289945)

“…Impedance was measured at frequencies of 100 Hz–100 kHz. Pulsed electrical field caused a 4-fold decrease in absolute tumor impedance and loss of frequency relaxation, suggestive of membrane breakdown. …”

Supplementary figure.1.tif by liang lv (5903513)

“…*p<0.05, **p< 0.01, scale bar, 200μm (a,b), <a></a><a>50μm (c)</a>, 100μm (d,g).</p>…”

Table_1_Estimating Factors Related to Fluoroquinolone Resistance Based on One Health Perspective: Static and Dynamic Panel Data Analyses From Europe.doc by Dandan Zhang (228849)

“…The 10% increase in veterinary AMC was related to a 1.65% decrease of P. aeruginosa resistance rates to fluoroquinolones (Coef. = −0.165, p = 0.019).…”

Inhibition of mitochondrial oxidation prevents adipogenic differentiation of hMSCs. by Yanmin Zhang (391964)

“…<p><b>A)</b> 100 nM rotenone decreased the baseline oxygen consumption rate (OCR) and maximal respiration capacity (induced by FCCP treatment) in hMSCs (n = 7 for each group). …”

<i>Setd2</i> deficiency altered genome-wide H3K36me3 occupancy and downstream gene expression. by Lijun Wang (176511)

“…Scale bar = 1 mm (upper); scale bar = 100 μm (lower). (B) Quantitative analysis of Oil Red O staining area. …”

Image1_Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.TIF by Burong Feng (11661529)

“…This study investigated the effect of ethyl 2-succinate-anthraquinone (Luhui derivative, LHD) on inflammation. In vitro, a THP-1 macrophage inflammation model, made by 100 ng/ml phorbol-12-myristate-13-acetate (PMA) and 1 μg/ml LPS for 24 h, was constructed. …”

Image2_Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.TIF by Burong Feng (11661529)

“…This study investigated the effect of ethyl 2-succinate-anthraquinone (Luhui derivative, LHD) on inflammation. In vitro, a THP-1 macrophage inflammation model, made by 100 ng/ml phorbol-12-myristate-13-acetate (PMA) and 1 μg/ml LPS for 24 h, was constructed. …”

<i>Cryptococcus neoformans</i> incubated for 8 days in hypoxia reactivated with pantothenic acid (PA) and culturable cells rewired in minimal medium (MM) dilutions. by Benjamin Hommel (523072)

“…Graph includes dot for the replicates, as well as median ± IQR (*p<0.01 compared to control in the same condition). <b>A</b>. The dilution of minimal medium from 100% to 10% (diluted MM) resulted in a progressive decrease of latency in 8D-HYPOx cells and to a lesser extend in STAT cells. …”

Effect of MTDH gene overexpression on clinical sensitivity of doxorubicin. by Zhenchuan Song (741160)

“…<p>(A) MTDH mRNA expression determined by real time-PCR after MTDH plasmid was transfected for 48 h in MDA-MB-231 cells (untransfected group 1.00±0.00, blank plasmid group 1.03±0.12 and MTDH transfected group 3.25±0.02). …”